Normal Development of the Lung and Premature Birth

Smith, Lucia; McKay, Karen; Asperen, Peter P Van; Selvadurai, Hiran; Fitzgerald, Dominic A.

doi:10.1016/j.prrv.2009.12.006

Cited by 174 publications

(151 citation statements)

References 28 publications

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“…Alongside the structural immaturity associated with preterm birth and subsequent development of BPD, many preterm infants have insufficient production and composition of pulmonary surfactant [13]. Surfactant is crucial for maintaining alveolar functional stability through lowering surface tension at the air–liquid interface and, thereby preventing lung collapse at end-expiration [13].…”

Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 99%

“…Surfactant is crucial for maintaining alveolar functional stability through lowering surface tension at the air–liquid interface and, thereby preventing lung collapse at end-expiration [13]. The biological role of surfactant, however, in modulating and maintaining pulmonary host defence against infection and inflammation has become increasingly recognised [14], with several studies reporting increased risk of infection and inflammation in term-born children and adults with surfactant deficiency or inactivation (Figure 1) [15,16].…”

Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 99%

Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

View full text Add to dashboard Cite

show abstract

“…Similarly, the pace of alveolar development and maturation differs between mouse and human (Plopper and Hyde, 2008;Smith et al, 2010) (Fig. 1).…”

Section: Lung Developmentmentioning

confidence: 94%

“…The histology of lung and airways and the dynamics and timing of their development differ strikingly between human and mouse (Plopper and Hyde, 2008;Smith et al, 2010). A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010).…”

Section: Lung Developmentmentioning

confidence: 99%

“…This stage is followed by the saccular stage, in which alveolar sacs, containing distinguishable ATI and ATII cells, form and surfactant secretion begins (Herriges and Morrisey, 2014;Morrisey and Hogan, 2010;Warburton et al, 2010). The saccular stage begins in late gestation, at E17.5, in the mouse, but relatively much earlier, at week 24, in humans (Smith et al, 2010). In the mouse, ATII and ATI cells probably develop from bipotential alveolar progenitors in the very tips of the branches, distal to the forming sacs Treutlein et al, 2014).…”

Section: Lung Developmentmentioning

confidence: 99%

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Modeling human lung development and disease using pluripotent stem cells

Snoeck

2015

Development

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Directed differentiation of human pluripotent stem cells (hPSCs) into mature cells, tissues and organs holds major promise for the development of novel approaches in regenerative medicine, and provides a unique tool for disease modeling and drug discovery. Sometimes underappreciated is the fact that directed differentiation of hPSCs also provides a unique model for human development, with a number of important advantages over model organisms. Here, I discuss the importance of using human stem cell models for understanding human lung development and disease.

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Prenatal vs Infant Vitamin D Supplementation and the Risk of Wheezing in Childhood

Greer

2018

JAMA

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Normal Development of the Lung and Premature Birth

Cited by 174 publications

References 28 publications

The impact of respiratory viruses on lung health after preterm birth

The impact of respiratory viruses on lung health after preterm birth

Modeling human lung development and disease using pluripotent stem cells

Prenatal vs Infant Vitamin D Supplementation and the Risk of Wheezing in Childhood

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