Normal Development of Local Neurovascular Interactions and the Diagnostic Value of Resting State Functional MRI in Neurovascular Deficiency Based on the Example of Neonatal Anesthesia Exposure

Aksenov, Daniil P.

doi:10.3389/fneur.2021.664706

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…A neonatal MRI should be performed without sedation when the child is fed and swaddled [ 80 ]. In our experience, infants who are less than 2 months old should be submitted to MRI without sedation in order to limit the side effects and avoid a prolonged post-exam observation [ 81 , 82 ]. It has been reported that neonatal sedation might affect the GABAergic systems, inducing learning and behavioral disabilities later in life.…”

Section: Postnatal Follow-upmentioning

confidence: 99%

Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up

Scelsa

2022

Diagnostics

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Brain abnormalities detected in fetal life are being increasingly recognized. Child neurologists are often involved in fetal consultations, and specific fetal neurology training has been implemented in many countries. Pediatric neurologists are asked to examine the data available and to contribute to the definition of the long-term outcomes. Ventriculomegaly, posterior fossa malformations, and agenesis/dysgenesis of corpus callosum are among the most common reasons for antenatal neurological consultations. Fetuses with central nervous system and extra-CNS anomalies should ideally be managed in secondary/tertiary hospitals where obstetricians who are experts in fetal medicine and pediatric specialists are available. Obstetricians play a critical role in screening, performing detailed neurosonography, and referring to other specialists for additional investigations. Clinical geneticists are frequently asked to propose diagnostic tests and counsel complex fetal malformations whose phenotypes may differ from those during postnatal life. Advances in fetal MRI and genetic investigations can support the specialists involved in counseling. Nevertheless, data interpretation can be challenging, and it requires a high level of expertise in a multidisciplinary setting. Postnatally, child neurologists should be part of an integrated multidisciplinary follow-up, together with neonatologists and pediatricians. The neurodevelopmental outcomes should be assessed at least up to school age. Children should be evaluated with formal tests of their gross motor, cognitive, language, fine motor/visuo-perceptual skills, and their behavior. In this perspective, fetal neurology can be regarded as the beginning of a long journey which continues with a prolonged, structured follow-up, support to the families, and transition to adult life. A review of the most common conditions is presented, along with the long-term outcomes and a proposal of the neurodevelopmental follow-up of children with CNS malformation which are diagnosed in uterus.

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Section: Postnatal Follow-upmentioning

confidence: 99%

Fetal Neurology: From Prenatal Counseling to Postnatal Follow-Up

Scelsa

2022

Diagnostics

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“…In addition to the traditional views on neuronal inhibition, GABAergic signaling is also involved in the regulation of cerebral blood flow. We would like to make a particular emphasis on this function because of its potential diagnostic and mechanistic value related to the long-term effects of neonatal anesthesia exposure [ 32 ].…”

Section: Function and Development Of The Gabaergic Systemmentioning

confidence: 99%

“…Since there are a range of possible severities of E-I imbalance, such that smaller shifts in this balance produce mostly disorders at the behavioral and cognitive level, whereas larger shifts result in neurological symptoms (e.g., seizures), we should first establish the typical level of imbalance accounted for by the delayed effects of neonatal anesthesia. There is a general consensus that profound neurological deficits (for example, epilepsy and cerebellar ataxia which manifest in cases of larger imbalances) are not typically associated with neonatal anesthesia [ 32 , 113 , 157 ]. Therefore, we will mostly discuss mild levels of E-I imbalance.…”

Section: Consequences Of Neonatal Anesthesiamentioning

confidence: 99%

Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia

Gascoigne

Serdyukova

Aksenov

2021

IJMS

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Human and animal studies have elucidated the apparent neurodevelopmental effects resulting from neonatal anesthesia. Observations of learning and behavioral deficits in children, who were exposed to anesthesia early in development, have instigated a flurry of studies that have predominantly utilized animal models to further interrogate the mechanisms of neonatal anesthesia-induced neurotoxicity. Specifically, while neonatal anesthesia has demonstrated its propensity to affect multiple cell types in the brain, it has shown to have a particularly detrimental effect on the gamma aminobutyric acid (GABA)ergic system, which contributes to the observed learning and behavioral deficits. The damage to GABAergic neurons, resulting from neonatal anesthesia, seems to involve structure-specific changes in excitatory-inhibitory balance and neurovascular coupling, which manifest following a significant interval after neonatal anesthesia exposure. Thus, to better understand how neonatal anesthesia affects the GABAergic system, we first review the early development of the GABAergic system in various structures that have been the focus of neonatal anesthesia research. This is followed by an explanation that, due to the prolonged developmental curve of the GABAergic system, the entirety of the negative effects of neonatal anesthesia on learning and behavior in children are not immediately evident, but instead take a substantial amount of time (years) to fully develop. In order to address these concerns going forward, we subsequently offer a variety of in vivo methods which can be used to record these delayed effects.

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“…Anesthetics that are classified as GABA agonists and glutamate antagonists ( Aksenov et al, 2019 ), have consistently been shown to produce significant neuroapoptosis that is directly correlated with dosage and duration of the anesthesia delivery ( Hadjikhani et al, 2006 ; Zheng et al, 2015 ; Liu et al, 2018 ). Moreover, the severity of apoptosis can create a loss of cortical neurons, of which a significant proportion are GABAergic inhibitory interneurons ( Istaphanous et al, 2013 ), and a further study has shown general anesthesia to directly disturb chloride channels ( Cabrera et al, 2020 ) thereby broadening the known contributory effects of anesthesia on neurodegeneration ( Aksenov, 2021 ). These neurodegenerative and apoptotic processes can alter the delicate excitatory/inhibitory balance of cortical networks ( Aksenov et al, 2020a ).…”

Section: Neurodegeneration and Chloride Channel Deficiencymentioning

confidence: 99%