Normal Development of Human Brain White Matter from Infancy to Early Adulthood: A Diffusion Tensor Imaging Study

Uda, Satoshi; Matsui, Mié; Tanaka, Chiaki; Uematsu, Akiko; Miura, Kayoko; Kawana, Izumi; Noguchi, Kyo

doi:10.1159/000373885

Cited by 101 publications

(74 citation statements)

References 33 publications

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“…Studies in the brain have reported age-related changes in the DTI parameters to describe the normal developmental characteristics from infancy to adulthood. 17 In addition, it is proposed that changes in DTI parameters in the brain as a function of age may result from decreasing water content, myelination of fiber tracts, and the thickening diameter of fiber tracts. 18 The SC is an extension of the brain, transmitting messages from the brain to the periphery and vice versa; and similar physiologic processes may occur in the SC.…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

Saksena¹,

Middleton

Krisa

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: DTI data of the normal healthy spinal cord in children are limited compared with adults and are typically focused on the cervical spinal cord. The purpose of this study was the following: to investigate the feasibility of obtaining repeatable DTI parameters along the entire cervical and thoracic spinal cord as a function of age in typically developing pediatric subjects; to analyze the DTI parameters among different transverse levels of the cervical and thoracic spinal cord; and to examine the sex differences in DTI parameters along the cervical and thoracic spinal cord.

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Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

Saksena¹,

Middleton

Krisa

et al. 2016

AJNR Am J Neuroradiol

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“…[30]), or even extended to studies of development in sub-cortical brain areas (e.g. [31]). However, this procedure is resource intensive.…”

Section: Discussionmentioning

confidence: 99%

Stereotaxic Magnetic Resonance Imaging Brain Atlases for Infants from 3 to 12 Months

Fillmore

Richards²,

Phillips-Meek³

et al. 2015

Dev Neurosci

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Background: Accurate labeling of brain structures within an individual or group is a key issue in neuroimaging. Methods for labeling infant brains have depended on the labels done on adult brains or average magnetic resonance imaging (MRI) templates based on adult brains. However, the features of adult brains differ in several ways from infant brains, so the creation of a labeled stereotaxic atlas based on infants would be helpful. The current work builds on the recent creation of age-appropriate average MRI templates during the first year (3, 4.5, 6, 7.5, 9, and 12 months) by creating anatomical label sets for each template. Methods: We created stereotaxic atlases for the age-specific average MRI templates. Manual delineation of cortical and subcortical areas was done on the average templates based on infants during the first year. We also applied a procedure for automatic computation of macroanatomical atlases for individual infant participants using two manually segmented adult atlases (Hammers, LONI Probabilistic Brain Atlas-LPBA40). To evaluate our methods, we did manual delineation of several cortical areas on selected individuals from each age. Linear and nonlinear registration of the individual and average template was used to transform the average atlas into the individual participant's space, and the average-transformed atlas was compared to the individual manually delineated brain areas. We also applied these methods to an external data set - not used in the atlas creation - to test generalizability of the atlases. Results: Age-appropriate manual atlases were the best fit to the individual manually delineated regions, with more error seen at greater age discrepancy. There was a close fit between the manually delineated and the automatically labeled regions for individual participants and for the age-appropriate template-based atlas transformed into participant space. There was close correspondence between automatic labeling of individual brain regions and those from the age-appropriate template. These relationships held even when tested on an external set of images. Conclusion: We have created age-appropriate labeled templates for use in the study of infant development at 6 ages (3, 4.5, 6, 7.5, 9, and 12 months). Comparison with manual methods was quite good. We developed three stereotaxic atlases (one manual, two automatic) for each infant age, which should allow more fine-grained analysis of brain structure for these populations than was previously possible with existing tools. The template-based atlases constructed in the current study are available online (http://jerlab.psych.sc.edu/NeurodevelopmentalMRIDatabase).

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“…However, there have been far fewer studies on the development of pathways from birth to adult ages. A few studies (Cancelliere et al., 2013; Uda et al., 2015) investigated white matter pathways from infant to adult ages looking at growth curves of pathways, but without specifically studying the cerebellar pathways and without considering laterality.…”

Section: Introductionmentioning

confidence: 99%

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

Levman

Lim

et al. 2016

Brain and Behavior

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IntroductionMany neurologic and psychiatric disorders are thought to be due to, or result in, developmental errors in neuronal cerebellar connectivity. In this connectivity analysis, we studied the developmental time‐course of cerebellar peduncle pathways in pediatric and young adult subjects.MethodsA cohort of 80 subjects, newborns to young adults, was studied on a 3T MR system with 30 diffusion‐weighted measurements with high‐angular resolution diffusion imaging (HARDI) tractography.ResultsQualitative and quantitative results were analyzed for age‐based variation. In subjects of all ages, the superior cerebellar peduncle pathway (SCP) and two distinct subpathways of the middle cerebellar peduncle (MCP), as described in previous ex vivo studies, were identified in vivo with this technique: pathways between the rostral pons and inferior‐lateral cerebellum (MCP cog), associated predominantly with higher cognitive function, and pathways between the caudal pons and superior‐medial cerebellum (MCP mot), associated predominantly with motor function.DiscussionOur findings showed that the inferior cerebellar peduncle pathway (ICP), involved primarily in proprioception and balance appears to have a later onset followed by more rapid development than that exhibited in other tracts. We hope that this study may provide an initial point of reference for future studies of normal and pathologic development of cerebellar connectivity.

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Normal Development of Human Brain White Matter from Infancy to Early Adulthood: A Diffusion Tensor Imaging Study

Cited by 101 publications

References 33 publications

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

Diffusion Tensor Imaging of the Normal Cervical and Thoracic Pediatric Spinal Cord

Stereotaxic Magnetic Resonance Imaging Brain Atlases for Infants from 3 to 12 Months

High‐angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults

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