Normal Colonic Motor Function and Structure

Frykman, Philip K.; Chen, Stephanie; Patel, Deven C.; Christensen, James

doi:10.1007/978-3-030-15647-3_4

Hirschsprung's Disease and Allied Disorders 2019

DOI: 10.1007/978-3-030-15647-3_4

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Normal Colonic Motor Function and Structure

Philip K. Frykman

Stephanie Chen

Deven C. Patel

et al.

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2022

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Cited by 1 publication

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Hirschsprung Disease for the Practicing Surgical Pathologist

Matsukuma¹,

Gui²,

Saadai

2022

American Journal of Clinical Pathology

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Objectives Hirschsprung disease (HD) is a congenital condition defined by the absence of ganglion cells in the distal-most portion of the gastrointestinal tract. Biopsies and resections for HD can be adrenaline inducing for the general surgical pathologist because specimens are infrequent; HD is 1 of only a few neuroanatomic diseases that general surgical pathologists diagnose; numerous preanalytic factors (eg, biopsy adequacy, surgeon sampling protocol, processing artifacts) can affect histologic interpretation; and most importantly, the diagnosis has high stakes. Methods We provide a comprehensive overview of the background, relevant clinical procedures, and pathologic assessment of HD. Grossing and frozen section protocols, an algorithmic approach to diagnosis, and histologic pearls and pitfalls are also discussed. Results Evaluation and recognition of the features of HD have evolved significantly in the past 2 decades with the discovery of the value of calretinin immunohistochemistry in the late 2000s and the recent development of straightforward and reproducible histologic criteria for identification of the HD transition zone. Conclusions These advancements have substantially improved the pathologist’s ability to reliably evaluate for HD. Nonetheless, as with any high-stakes surgical pathology specimen, clear communication with the clinical team is essential.

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Hirschsprung Disease for the Practicing Surgical Pathologist

Matsukuma¹,

Gui²,

Saadai

2022

American Journal of Clinical Pathology

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Normal Colonic Motor Function and Structure

Cited by 1 publication

References 27 publications

Hirschsprung Disease for the Practicing Surgical Pathologist

Hirschsprung Disease for the Practicing Surgical Pathologist

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