Normal Brain Tissue Volumes after Long-Term Recovery in Anorexia and Bulimia Nervosa

Altered Insula Response to Taste Stimuli in Individuals Recovered from Restricting-Type Anorexia Nervosa

“…A recent study from our group, including some of these subjects, showed normal brain volume after recovery from AN (Wagner et al, 2006b). Still, it is possible that the recovered AN brains may systematically have more alignment error than the control subjects.…”

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa

“…The lack of a significant correlation between BMI and reduced grey matter volume and cortical thickness might argue against a simple association between nutritional state and abnormal cortical structure, although some studies have demonstrated a normalization of the total grey matter volume associated with long-term recovery (> 1 yr) from the anorexia. 56 Our findings point toward specific cerebral morphological impairments, which can be considered not as a direct consequence of malnutrition, but rather as a premorbid symptom of anorexia nervosa that accompanies neuropsychological impairments. However, we cannot determine from the present study whether the observed grey matter and cortical thickness reductions precede the disease or develop during its course.…”

Neuropsychological study of underweight and “weight‐recovered” anorexia nervosa compared with bulimia nervosa and normal controls

“…8,9 While a number of structural neuroimaging studies in acutely ill AN and BN patients have shown increased cerebrospinal fluid and de-creased gray and white matter volumes, it is possible that such changes may be reversible after long-term recovery. 36 Other studies have suggested impaired neuronal circuitry and orbitofrontal cortex involvement in AN. [37][38][39] There has been a paucity of studies directly comparing neuropsychological functioning in AN and BN participants.…”