Normal and resonance Raman spectroelectrochemistry with fiber optic light collection

Schwab, Scott D.; McCreery, Richard L.; Gamble, F. T.

doi:10.1021/ac00125a029

Cited by 53 publications

(25 citation statements)

References 24 publications

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“…In the early stages of the field, Raman probes without additional filtering (Schwab et al and ; Shim and Wilson , Archibald et al ) were constructed. Already these first applications of Raman fiber probes (not yet for biomedical applications) revealed that the fiber configuration is very important for the performance of the sensors, also shown by Lewis et al in .…”

Section: Optical Fibers For Raman Probesmentioning

confidence: 99%

Fiber optic probes for linear and nonlinear Raman applications – Current trends and future development

Latka

Dochow

Krafft

et al. 2013

Laser & Photonics Reviews

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This review focuses on fiber optic probes for linear and nonlinear Raman spectroscopy, especially for medical applications. It aims at providing an overview over contemporary technology, recent first clinical trials, and helps identifying future developments necessary to bring the emerging technology to clinical end users. After a short introduction to linear and nonlinear Raman spectroscopic modalities, general design considerations will be discussed and compared to common fiber probe setups. Subsequently, examples for medical applications of fiber optic Raman probes will be given concentrating on probes for linear Raman spectroscopy as these devices are technologically more mature compared to their counterparts based on nonlinear Raman spectroscopy. The review also includes a brief summary of first multimodal fiber optic probes and highlights their benefits for clinical applications. Finally, probes are introduced which employ either nonlinear Raman spectroscopy or surface enhanced spectroscopy.

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Section: Optical Fibers For Raman Probesmentioning

confidence: 99%

Fiber optic probes for linear and nonlinear Raman applications – Current trends and future development

Latka

Dochow

Krafft

et al. 2013

Laser & Photonics Reviews

View full text Add to dashboard Cite

show abstract

“…Nevertheless, short single multimode fiber is advantageous when the physical diameter of the probe is restricted . Some designs such as free space excitation with multiple‐fiber collection and dual‐fiber probes with forward‐scattering configuration avoid the silica background and coupling efficiency problem, but are impractical for most oncological applications . Most prevailing Raman FOP designs are related to the prototypes reported over 30 years ago .…”

Section: Instrumentationmentioning

confidence: 99%

Real‐time in vivo cancer diagnosis using raman spectroscopy

Wang

Zhao

Short

et al. 2014

Journal of Biophotonics

118

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Raman spectroscopy has becoming a practical tool for rapid in vivo tissue diagnosis. This paper provides an overview on the latest development of real-time in vivo Raman systems for cancer detection. Instrumentation, data handling, as well as oncology applications of Raman techniques were covered. Optic fiber probes designs for Raman spectroscopy were discussed. Spectral data pre-processing, feature extraction, and classification between normal/benign and malignant tissues were surveyed. Applications of Raman techniques for clinical diagnosis for different types of cancers, including skin cancer, lung cancer, stomach cancer, oesophageal cancer, colorectal cancer, cervical cancer, and breast cancer, were summarized. Schematic of a real-time Raman spectrometer for skin cancer detection. Without correction, the image captured on CCD camera for a straight entrance slit has a curvature. By arranging the optic fiber array in reverse orientation, the curvature could be effectively corrected.

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“…Andrade and others have noted the presence of background photoluminescence and Raman scattering from optical fibers and plastic cladding (53)(54)(55). This background light is a serious interferent for fluorescence sensors that are operated remotely since, as the fiber lengthens, the signal is attenuated while the background increases.…”

Section: Approaches For Improved Fiberoptic Biosensorsmentioning

confidence: 99%