Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats

Evaluation of in vivo wound healing activity of methanol extract of Achyranthes aspera L.

“…The tracing was then shifted to graph paper, from which the wound surface area was obtained. The measured surface area at different days of post wound creation was employed to calculate the percentage of wound contraction, taking initial size of wound as 100%, according to (Shenoy et al, 2011).…”

“…Falling of scab leaving no raw wound behind was taken as end point of complete epithelization and the days required for this were taken as period of epithelization (Shenoy et al, 2011).…”

Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9

“…Sesamol is a nonfat antioxidant in sesame oil [22]; it is effective against drug-induced and chemically induced organ injuries [23,24]. The anti-MMP-9 [25], anti-inflammatory [26][27][28], antioxidant [29][30][31], and anti-injury, and wound healing [32,33] properties of sesamol contribute to the therapeutic efficacy of sesamol against disease models. In addition, effective doses of sesamol (range, 1-30 mg/kg) have no known adverse side effects [34,35].…”

Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

“…Sesame oil is a common edible oil, high in vitamins, minerals, phytosterols, and polyunsaturated fatty acids [17]. In China and India, people used sesame oil to ameliorate burns, and as a lubricant in massage [25]. In addition, sesame oil has an antimicrobial effect against Staphylococcus, and it suppresses fungal infections [20].…”