Normal and abnormal dental development

Milétich, Isabelle; Sharpe, Paul T.

doi:10.1093/hmg/ddg085

Cited by 152 publications

(114 citation statements)

References 47 publications

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“…The tooth is an advantageous model system for analyzing molecular mechanisms regulating organ formation and cell differentiation (for review, see Peters and Balling, 1999;Peterkova et al, 2000;Miletich and Sharpe, 2003;Thesleff, 2003). The formation of the tooth is controlled by reciprocal signaling between ectoderm-derived epithelium and neural crest-derived mesenchyme.…”

Section: Introductionmentioning

confidence: 99%

Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth

et al. 2005

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Wnt signaling is essential for tooth formation. Members of the Dickkopf (Dkk) family modulate the Wnt signaling pathway by binding to the Wnt receptor complex. Comparison of Dkk1, -2, and -3 mRNA expression during mouse tooth formation revealed that all three genes showed distinct spatiotemporally regulated expression patterns. Dkk1 was prominently expressed in the distal, incisor-bearing mesenchyme area of the mandibular process during the initial stages of tooth formation. During molar morphogenesis Dkk1 was detected in the dental mesenchyme, including the preodontoblasts. Dkk2 was seen in the dental papilla, whereas Dkk3 was specifically expressed in the putative epithelial signaling centers, the primary and secondary enamel knots. Postnatally, Dkk1 was prominently expressed in the preodonto-and odontoblasts, while Dkk3 mRNAs were transiently seen in the preameloblasts before the onset of enamel matrix secretion. These results suggest that modulation of Wnt-signaling by Dkks may serve important functions in patterning of dentition as well as in crown morphogenesis and dental hard-tissue formation. Developmental Dynamics 233:161-166, 2005.

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Section: Introductionmentioning

confidence: 99%

Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth

et al. 2005

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“…The enamel knot expresses signaling molecules that stimulate proliferation of surrounding epithelium and mesenchyme. The early bell stage of tooth development (E15.5-E16.5) is characterized by continued epithelial expansion and differentiation into the inner (IEE) and outer enamel epithelium (OEE), stratum intermedium (SI), and stellate reticulum (1)(2)(3)(4)(5)(6).…”

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confidence: 99%

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis

Golonzhka

Metzger

Bornert

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development. Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell lineage. In Ctip2 ؊/؊ mice, tooth morphogenesis appeared to proceed normally through the cap stage but developed multiple defects at the bell stage. Mutant incisors and molars were reduced in size and exhibited hypoplasticity of the stellate reticulum. An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. Perturbations of gene expression were also observed in the mandible of Ctip2 ؊/؊ mice: expression of the ameloblast markers amelogenin, ameloblastin, and enamelin was down-regulated, as was expression of Msx2 and epiprofin, transcription factors implicated in the tooth development and ameloblast differentiation. These results suggest that Ctip2 functions as a critical regulator of epithelial cell fate and differentiation during tooth morphogenesis.amelogenesis ͉ cellular differentiation ͉ enamel ͉ tooth development ͉ transcription factor

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“…QTL mapping studies in animals provide evidence for genes of major effect that influence specific traits. Several attempts have been made by employing animal models to determine the genetic linkage to tooth morphology [Jernvall et al, 1994;Jernvall, 1995;Vaahtokari et al, 1996;Jernvall et al, 1998;Jernvall and Jung, 2000;Miletich and Sharpe, 2003]. One study located and examined specific quantitative trait loci (QTL) affecting the size and shape of mandibular molars in mice.…”

Section: Discussionmentioning

confidence: 99%

“…Located at the tip of the tooth buds, the enamel knots act as the epithelial signaling centres to communicate with the mesenchymal tissues which appear to be crucial for correct tooth patterning and morphogenesis [Jernvall et al, 1994;Jernvall, 1995;Vaahtokari et al, 1996;Jernvall et al, 1998]. Recently, it has been demonstrated that a second set of signaling centres, known as secondary enamel knots, function to determine the multicuspid pattern of molar crowns [Jernvall and Jung, 2000;Miletich and Sharpe, 2003]. These studies have provided great insight into the molecular and genetic basis of tooth morphogenesis.…”

Section: Discussionmentioning

confidence: 99%

Inheritance of Occlusal Topography: A Twin Study

Corby

Elliot

et al. 2008

Eur Arch Paediatr Dent

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Aim-This was to determine the relative contribution of genetic factors on the morphology of occlusal surfaces of mandibular primary first molars by employing the twin study model. Methods-The occlusal morphology of mandibular primary first molar teeth from dental casts of 9 monozygotic (MZ) twin pairs and 12 dizygotic (DZ) twin pairs 4 to 7 years old, were digitized by contact-type three-dimensional (3D) scanner. To compare the similarity of occlusal morphology between twin sets, each twin pair of occlusal surfaces was superimposed to establish the best fit by using computerized least squared techniques. Heritability was computed using a variance component model, adjusted for age and gender.Results-DZ pairs demonstrated a greater degree of occlusal morphology variance. The total amount of difference in surface overlap was 0.0508 mm (0.0018 (inches) for the MZ (n=18) sample and 0.095 mm (0.0034 inches) for the DZ (n=24) sample and were not statistically significant (p=0.2203). The transformed mean differences were not statistically significantly different (p=0.2203). Heritability estimates of occlusal surface areas for right and left mandibular primary first molars were 97.5% and 98.2% (p<0.0001), respectively.Conclusions-Occlusal morphology of DZ twin pairs was more variable than that of MZ twin pairs. Heritability estimates revealed that genetic factors strongly influence occlusal morphology of mandibular primary first molars.

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Normal and abnormal dental development

Cited by 152 publications

References 47 publications

Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth

Dynamic expression of Wnt signaling-related Dickkopf1, -2, and -3 mRNAs in the developing mouse tooth

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis

Inheritance of Occlusal Topography: A Twin Study

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