2012
DOI: 10.1016/j.neuroimage.2011.07.054
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Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia

Abstract: Functional neuroimaging studies have implicated the involvement of the amygdala and ventrolateral prefrontal cortex (vlPFC) in the pathophysiology of bipolar disorder. Hyperactivity in the amygdala and hypoactivity in the vlPFC have been reported in manic bipolar patients scanned during the performance of an affective faces task. Whether this pattern of dysfunction persists during euthymia is unclear. Using functional magnetic resonance imaging (fMRI), 24 euthymic bipolar and 26 demographically matched healthy… Show more

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Cited by 77 publications
(66 citation statements)
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“…However, our findings are consistent with previous Stroop studies that reported reduced activation to conflict trials in IFG/MFG, medial SFG/SMA, parietal cortex, and basal ganglia in euthymic BD patients (Malhi et al, 2005;Strakowski et al, 2005;Kronhaus et al, 2006;Roth et al, 2006;Pompei et al, 2011). Stroop-like conflict has rarely been studied during affective episodes, but decreased activity in the IFG, together with hypoactivation of the basal ganglia, thalamus and/or parietal areas, was reported during inhibition and emotion categorization tasks in manic and depressed patients, as well as euthymic patients Foland-Ross et al, 2012;Vizueta et al, 2012). Together with our findings, these studies suggest that functional anomalies in ventrolateral prefrontal-striato-pallido-thalamic networks may persist in BD patients across clinical changes, but to a different degree depending on mood and available cognitive resources.…”
Section: Discussionsupporting
confidence: 91%
“…However, our findings are consistent with previous Stroop studies that reported reduced activation to conflict trials in IFG/MFG, medial SFG/SMA, parietal cortex, and basal ganglia in euthymic BD patients (Malhi et al, 2005;Strakowski et al, 2005;Kronhaus et al, 2006;Roth et al, 2006;Pompei et al, 2011). Stroop-like conflict has rarely been studied during affective episodes, but decreased activity in the IFG, together with hypoactivation of the basal ganglia, thalamus and/or parietal areas, was reported during inhibition and emotion categorization tasks in manic and depressed patients, as well as euthymic patients Foland-Ross et al, 2012;Vizueta et al, 2012). Together with our findings, these studies suggest that functional anomalies in ventrolateral prefrontal-striato-pallido-thalamic networks may persist in BD patients across clinical changes, but to a different degree depending on mood and available cognitive resources.…”
Section: Discussionsupporting
confidence: 91%
“…The ability to recognize emotion expressions was evaluated in both groups using the following three tasks: 1) the Facial Emotion Identification Test (FEIT) [8][9][10][11][12][13][14][15][16] shows 19 black and white pictures of six basic emotions (happy, sad, anger, surprise, disgust, and shame) which the participant must identify; 2) the Facial Emotion Discrimination Test (FEDT) [8][9][10][11][12][13][14][15][16] comprises 30 pairs of black and white pictures with faces presented concurrently. This test requires the participant to determine whether the two faces in each pair of pictures are displaying the same or different emotions; and 3) Emotion Recognition-40 (ER40).…”
Section: Instrumentsmentioning
confidence: 99%
“…This test requires the participant to determine whether the two faces in each pair of pictures are displaying the same or different emotions; and 3) Emotion Recognition-40 (ER40). [9][10][11][12][13][14][15][16][17] This test shows 40 pictures in which participants have to identify the displayed emotion. There are five options: anger, sad, fear, happy, and no emotion.…”
Section: Instrumentsmentioning
confidence: 99%
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