Norkurarinone and isoxanthohumol inhibit high glucose and hypoxia-induced angiogenesis via improving oxidative stress and regulating autophagy in human retinal microvascular endothelial cells

Zhao, Kairui; Li, Yadi; Qiu, Yongyi; Huang, Ruiting; Lin, Minling; Chen, Lei; Liu, Yi

doi:10.1016/j.bbrc.2022.09.095

Cited by 10 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In molecular studies, norkurarinone and isoxanthohumol could increase the mRNA levels of PI3K, AKT, and mTOR and inhibit autophagy, thereby leading to the downregulation of Beclin-1, LC3-Ⅱ, and ATG5 expression and the upregulation of P62 expression; this reduces the production of ROS and protects the mitochondrial structure. In summary, norkurarinone and isoxanthohumol inhibit autophagy by activating the PI3K/AKT/mTOR signaling pathway to prevent the formation of new blood vessels ( Zhao et al, 2022 ).…”

Section: Natural Products For Regulating Diabetic Microvascular Compl...mentioning

confidence: 99%

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Liu,

Zhao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

As the quality of life improves, the incidence of diabetes mellitus and its microvascular complications (DMC) continues to increase, posing a threat to people’s health and wellbeing. Given the limitations of existing treatment, there is an urgent need for novel approaches to prevent and treat DMC. Autophagy, a pivotal mechanism governing metabolic regulation in organisms, facilitates the removal of dysfunctional proteins and organelles, thereby sustaining cellular homeostasis and energy generation. Anomalous states in pancreatic β-cells, podocytes, Müller cells, cardiomyocytes, and Schwann cells in DMC are closely linked to autophagic dysregulation. Natural products have the property of being multi-targeted and can affect autophagy and hence DMC progression in terms of nutrient perception, oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis. This review consolidates recent advancements in understanding DMC pathogenesis via autophagy and proposes novel perspectives on treating DMC by either stimulating or inhibiting autophagy using natural products.

show abstract

Section: Natural Products For Regulating Diabetic Microvascular Compl...mentioning

confidence: 99%

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Liu,

Zhao,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Norkurarinone and isoxanthohumol have been shown to enhance cellular oxidative stress, activate the PI3K/AKT/mTOR signaling pathway, and regulate autophagy dysregulation. These effects have been found to protect human retinal microvascular endothelial cells under conditions of high glucose and hypoxia ( 222 ). Procyanidin , a polyphenolic compound, also exhibits anti-diabetic properties.…”

Section: Correlation Between Autophagy and T2dm As Well As Its Compli...mentioning

confidence: 99%

The role of autophagy in the treatment of type II diabetes and its complications: a review

Zhao,

Bie,

Pang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a significant threat to human life and health. Consequently, there is an urgent requirement to discover effective drugs and investigate the pathogenesis of T2DM. Autophagy plays a crucial role in maintaining normal islet structure. However, in a state of high glucose, autophagy is inhibited, resulting in impaired islet function, insulin resistance, and complications. Studies have shown that modulating autophagy through activation or inhibition can have a positive impact on the treatment of T2DM and its complications. However, it is important to note that the specific regulatory mechanisms vary depending on the target organ. This review explores the role of autophagy in the pathogenesis of T2DM, taking into account both genetic and external factors. It also provides a summary of reported chemical drugs and traditional Chinese medicine that target the autophagic pathway for the treatment of T2DM and its complications.

show abstract

“…[7,8] Furthermore, the relationship between autophagy and apoptosis determines the extent of cellular oxidative stress and the progression of DR. [9][10][11] The quality of life of patients with DR is significantly affected, but current pharmacologic treatment regimens are based on retinal laser coagulation, hypoglycemic agents, vascular endothelial growth factor (VEGF) therapy, and surgery. [12] Consequently, how to target the prevention and control of DR and protect the visual function of patients has become one of the important tasks of modern medical research.…”

Section: Introductionmentioning

confidence: 99%

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Hu,

Wang,

et al. 2023

Medicine

View full text Add to dashboard Cite

Diabetic retinopathy (DR) has become one of the top 3 blinding eye diseases in the world. In spite of recent therapeutic breakthroughs, it is not yet possible to cure DR through pharmacotherapy. Cell death is thought to play a key role in the pathogenesis of DR. Moderate modulation of cellular autophagy and inhibition of apoptosis have been identified as effective targets for the treatment of DR. Numerous phytochemicals have emerged as potential new drugs for the treatment of DR. We collected basic DR research on herbal monomers through keywords such as autophagy and apoptosis, and conducted a systematic search for relevant research articles published in the PubMed database. This review provides the effects and reports of herbal monomers on various DR cellular and animal models in vivo and in vitro in the available literature, and emphasizes the importance of cellular autophagy and apoptosis as current DR therapeutic targets. Based on our review, we believe that herbal monomers that modulate autophagy and inhibit apoptosis may be potentially effective candidates for the development of new drugs in the treatment of DR. It provides a strategy for further development and application of herbal medicines for DR treatment.

show abstract

Norkurarinone and isoxanthohumol inhibit high glucose and hypoxia-induced angiogenesis via improving oxidative stress and regulating autophagy in human retinal microvascular endothelial cells

Cited by 10 publications

References 35 publications

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

The role of autophagy in the treatment of type II diabetes and its complications: a review

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review

Contact Info

Product

Resources

About