Norian SRS Cement Compared With Conventional Fixation in Distal Radial Fractures

Cassidy, Charles; Jupiter, Jesse B.; Cohen, Mark S.; Delli-Santi, Michelle; Fennell, Colin; Leinberry, Charles F.; Husband, Jeffrey B.; Ladd, Amy L.; Seitz, William; Constanz, Brent

doi:10.2106/00004623-200311000-00010

Cited by 172 publications

(129 citation statements)

References 37 publications

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“…Within the last two decades, many other biogenic and synthetic materials were evaluated for their use as bone substitutes. Calcium phosphate-and apatite-based bone cements, porous composites as well as other types of biomaterials have been clinically applied for treatment of fractures and bone defects [40][41][42]. They are, depending on their chemical composition and porosity osteoconductive, biodegradable and are integrated into given bone defects.…”

Section: Biomaterialsmentioning

confidence: 99%

Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

461

350

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Bone defects represent a medical and socioeconomic challenge. Different types of biomaterials are applied for reconstructive indications and receive rising interest. However, autologous bone grafts are still considered as the gold standard for reconstruction of extended bone defects. The generation of bioartificial bone tissues may help to overcome the problems related to donor site morbidity and size limitations. Tissue engineering is, according to its historic definition, an "interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function". It is based on the understanding of tissue formation and regeneration and aims to rather grow new functional tissues than to build new spare parts. While reconstruction of small to moderate sized bone defects using engineered bone tissues is technically feasible, and some of the currently developed concepts may represent alternatives to autologous bone grafts for certain clinical conditions, the reconstruction of largevolume defects remains challenging. Therefore vascularization concepts gain on interest and the combination of tissue engineering approaches with flap prefabrication techniques may eventually allow application of bone-tissue substitutes grown in vivo with the advantage of minimal donor site morbidity as compared to conventional vascularized bone grafts. The scope of this review is the introduction of basic principles and different components of engineered bioartificial bone tissues with a strong focus on clinical applications in reconstructive surgery. Concepts for the induction of axial vascularization in engineered bone tissues as well as potential clinical applications are discussed in detail.

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Section: Biomaterialsmentioning

confidence: 99%

Tissue engineering of bone: the reconstructive surgeon's point of view

Kneser¹,

Schaefer

Polykandriotis³

et al. 2006

J Cellular Molecular Medi

461

350

View full text Add to dashboard Cite

show abstract

“…One of the main concerns of clinicians is to reach higher rates of bioresorption, an improvement of bone reconstruction and to a lesser extent, higher mechanical resistance [33]. Besides, clinical application of the cements in comminuted fractures revealed penetration of the viscous paste into the joint space [572][573][574]. The interested readers are referred to a paper on cement leakage during vertebroplasty [575].…”

Section: Brief Conclusion On the Medical Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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“…55 Calcium phosphate also suffers from inherent weakness under load and has an extremely slow resorption rate (30% to 60% at 1 year). 39 Tricalcium phosphate is equally slow to resorb and is very brittle. Calcium sulfate absorbs very quickly (4 to 12 weeks) although the resorption occurs faster than bone growth occurs, which results in structural instability and weakness under loading.…”

Section: Discussionmentioning

confidence: 99%

“…38 However, a randomized study of 323 patients with distal radius fractures treated with or without calcium phosphate cement for metaphyseal defect filling showed no group differences in grip strength, range of motion, or quality of life at 3 months and 1 year. 39 Furthermore, extravasation into the surrounding soft tissues occurred in 70% of patients treated with calcium phosphate cement. Painful soft tissue reactions have also been reported in up to 20% of patients following calcium phosphate cement injection.…”

Section: Ceramic Bone Graft Substitutesmentioning

confidence: 99%

Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

Miller¹,

Block²

2011

ORR

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A variety of bone grafts and bone graft substitutes is available for treatment of osseous defects although adequate reconstruction of the residual void following fracture, arthroplasty, or tumor/cyst resection remains a therapeutic challenge. This narrative review evaluates the peer-reviewed literature and examines relevant outcomes in patients treated with bone grafts and bone graft substitutes for surgical management of osseous defects. Although autograft, xenograft, and ceramic bone graft substitutes are used for a variety of orthopedic applications, they have distinct limitations in clinical practice. Bone allograft material is a safe and effective adjunct to treatment of osseous defects.

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Norian SRS Cement Compared With Conventional Fixation in Distal Radial Fractures

Cited by 172 publications

References 37 publications

Tissue engineering of bone: the reconstructive surgeon's point of view

Tissue engineering of bone: the reconstructive surgeon's point of view

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Perspectives on the clinical utility of allografts for bone regeneration within osseous defects: a narrative review

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