Norfloxacin suppresses Leptospira-induced inflammation through inhibiting p65 and ERK phosphorylation and NLRP3 inflammasome activation

Xie, Xufeng; Zhang, Wenlong; Chen, Xi; Wu, Di; Cao, Yongguo

doi:10.1016/j.micpath.2021.105315

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…The leptospirosis-infected subjects treated with the antibiotics like beta-lactam, cephalosporin, and doxycycline showed a decreased risk of dementia when compared with the group without antibiotic medications [81]. More recent study indicated that norfloxacin suppressed Leptospira-induced inflammation and it may be a potential candidate for suppressing inflammatory storms [82 ▪ ]. Study on new systems science insights on proteome, posttranslational modifications, and pathogen–host interaction promises rational drug design, and peptide engineering [83].…”

Section: Systemic Treatmentmentioning

confidence: 99%

Ocular leptospirosis: lack of awareness among ophthalmologists and challenges in diagnosis

Sivakumar¹

2022

Current Opinion in Ophthalmology

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Purpose of reviewSystemic leptospirosis exists worldwide. But leptospiral uveitis, an important late complication is not identified by ophthalmologists in several countries.Recent findingsIn the last 18 months numerous publications, especially on epidemiology, surveillances, and novel rapid diagnostic kits to test at the point of care site on leptospirosis have been published from all over the world. However, publications from ophthalmologists are very scarce. Remarkably ophthalmologists should know the global burden of leptospirosis, prevalence of the disease in their country, demographic factors associated, risk factors, and systemic signs to elicit relevant history and travel history. They should be aware of recent advances in investigations to confirm their clinical diagnosis.SummaryIt is quite evident from this work that leptospirosis is prevalent worldwide. Ophthalmologists’ awareness has to improve to identify the etiological diagnosis. They should have access to simple, less expensive, and less cumbersome laboratory tests.

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Section: Systemic Treatmentmentioning

confidence: 99%

Ocular leptospirosis: lack of awareness among ophthalmologists and challenges in diagnosis

Sivakumar¹

2022

Current Opinion in Ophthalmology

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The ameliorative effects of topical gemifloxacin alone or in combination with clobetasol propionate on imiquimod-induced model of psoriasis in mice

Salman,

Al-Zubaidy,

Abbas

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The pyroptosis mechanism of ototoxicity caused by unconjugated bilirubin in neonatal hyperbilirubinemia

Sun

et al. 2023

Biomedicine & Pharmacotherapy

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Norfloxacin suppresses Leptospira-induced inflammation through inhibiting p65 and ERK phosphorylation and NLRP3 inflammasome activation

Cited by 4 publications

References 22 publications

Ocular leptospirosis: lack of awareness among ophthalmologists and challenges in diagnosis

Ocular leptospirosis: lack of awareness among ophthalmologists and challenges in diagnosis

The ameliorative effects of topical gemifloxacin alone or in combination with clobetasol propionate on imiquimod-induced model of psoriasis in mice

The pyroptosis mechanism of ototoxicity caused by unconjugated bilirubin in neonatal hyperbilirubinemia

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