Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio)

Hou, Liping; Chen, Shanduo; Shi, Wen; Chen, Haishan; Liang, Yan‐Qiu; Wang, Xiaolan; Tan, Jiefeng; Wang, Yifan; Deng, Xikai; Zhan, Manjun; Long, Jianzhao; Cai, Guowei; Luo, Shaowen; Zhang, Cuiping; Liu, Juan; Leung, Jonathan Y.S.; Xie, Lingtian

doi:10.1016/j.ecoenv.2020.110496

Cited by 13 publications

(6 citation statements)

References 44 publications

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“…In the present study, 7.6 ng/L NET significantly decreased the mRNA expression level of pgr in the ovary of marine medaka; 7.6 ng/L and 80.1 ng/L NET extremely significant decreased the mRNA expression levels of pgr and gr in the male liver. Similar results have been reported in zebrafish 80,81 . Hou et al treated female zebrafish with 3.1, 36.2 and 398.6 ng/L NET for 60 days and found that the mRNA expression level of pgr decreased significantly 80 .…”

Section: Discussionsupporting

confidence: 80%

“…Similar results have been reported in zebrafish 80,81 . Hou et al treated female zebrafish with 3.1, 36.2 and 398.6 ng/L NET for 60 days and found that the mRNA expression level of pgr decreased significantly 80 . The results of Zhang et al's treatment of adult zebrafish and embryos with synthetic progesterone p4 also showed that p4 can significantly inhibit the transcription levels of pgr and gr 81 …”

Section: Discussionsupporting

confidence: 63%

“…Similar results have been reported in zebrafish. 80 The results of Zhang et al's treatment of adult zebrafish and embryos with synthetic progesterone p4 also showed that p4 can significantly inhibit the transcription levels of pgr and gr. 81 In summary, a simple assessment of the potential risks of NET aquatic organisms can be made.…”

Section: Gonadal Histological Analysis Following Exposure To Netmentioning

confidence: 99%

“…80,81 Hou et al treated female zebrafish with 3.1, 36.2 and 398.6 ng/L NET for 60 days and found that the mRNA expression level of pgr decreased significantly.…”

mentioning

confidence: 99%

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Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Dong

Chen

et al. 2022

Environmental Toxicology

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Norethindrone (NET) is a widely used synthetic progestin, which appears in water environments and threatens aquatic organisms. In this study, marine medaka (Oryzias melastigma) larvae were exposed to 7.6 and 80.1 ng/L NET for 190 days. The effects of NET on growth, sex differentiation, gonad histology and transcriptional expression profiles of hypothalamic-pituitary-gonadal (HPG) axis-related genes were determined. The results showed that exposure to 80.1 ng/L NET caused an all-male marine medaka population and significantly decreased the growth of males. Exposure to 7.6 ng/L NET increased the ratio of males/females in the marine medaka population, decreased the growth of males and delayed the ovary maturation in females.However, the sperm maturation was accelerated by 7.6 or 80.1 ng/L NET. In females, the transcription levels of cytochrome P450 aromatase (cyp19a1a) and progesterone receptor (pgr) in ovaries, glucocorticoid receptor (gr) and vitellogenin (vtg) in livers were suppressed after exposure to 7.6 ng/L NET, which may cause delayed ovary maturation. In males, NET significantly decreased the transcription levels of follicle stimulating hormone β (fshβ) and Luteinizing hormone β (lhβ)in the brain, Estrogen receptor β (erβ)，gr and pgr in the liver, and vitellogenin receptor (vtgr) in the testes, while NET of 80.1 ng/L led to a significant up-regulation of steroidogenic acute regulatory protein (star) in the testes of males. These results showed that NET could influence growth, sex differentiation and gonadal maturation and significantly alter the transcriptional expression levels of HPG axis-related genes.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 63%

Section: Gonadal Histological Analysis Following Exposure To Netmentioning

confidence: 99%

“…80,81 Hou et al treated female zebrafish with 3.1, 36.2 and 398.6 ng/L NET for 60 days and found that the mRNA expression level of pgr decreased significantly.…”

mentioning

confidence: 99%

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Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Dong

Chen

et al. 2022

Environmental Toxicology

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“…Alteration of mating behaviours, ovary histology and hormone production in zebrafish (D. rerio). [114] Alters growth, reproductive histology, and gene expression in zebrafish (D. rerio).…”

Section: Ntdmentioning

confidence: 99%

Synthetic Progestins in Waste and Surface Waters: Concentrations, Impacts and Ecological Risk

Rocha

2022

Toxics

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Synthetic progestins (PGs) are a large family of hormones used in continuously growing amounts in human and animal contraception and medicinal therapies. Because wastewater treatment plants (WWTPs) are unable to eradicate PGs after excretion, they are discharged into aquatic systems, where they can also be regenerated from conjugated PG metabolites. This review summarises the concentrations of 12 PGs in waters from 2015 to 2021. The selected PGs were considered of particular interest due to their wide use, activity, and hormonal derivation (from testosterone, progesterone, and spirolactone). We concluded that PGs had been analysed in WWTPs influents and effluents and, to a lesser extent, in other matrices, including surface waters, where their concentrations range from ng/L to a few µg/L. Because of their high affinity for cell hormone receptors, PGs are endocrine disruptor compounds that may alter the reproductive fitness and development of biota. This review focused on their biological effects in fish, which are the most used aquatic model organisms to qualify the impacts of PGs, highlighting the risks that environmental concentrations pose to their health, fecundity, and fertility. It is concluded that PGs research should be expanded because of the still limited data on their environmental concentrations and effects.

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Norethisterone (Norethindrone)

Mostafalou

Mohammadi

2024

Encyclopedia of Toxicology

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Norethindrone alters mating behaviors, ovary histology, hormone production and transcriptional expression of steroidogenic genes in zebrafish (Danio rerio)

Cited by 13 publications

References 44 publications

Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)

Synthetic Progestins in Waste and Surface Waters: Concentrations, Impacts and Ecological Risk

Norethisterone (Norethindrone)

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