Norepinephrine may be an underlying factor in chemobrain

Abstract

Chemotherapy is a widely used and effective treatment for many types of neoplasms, but it is also frequently accompanied by psychological deficits that are referred to as chemotherapy-related cognitive impairment (CRCI), or colloquially as "chemobrain." 1 The pathophysiological processes that underlie CRCI are only beginning to be elucidated. This letter briefly Paul J. Fitzgerald alone conceived of, wrote, and edited this publication.

Natural products for the treatment of chemotherapy-related cognitive impairment and prospects of nose-to-brain drug delivery

“…Notably, the most common neurological drugs improve cognitive deficits by modulating neurotransmitter release. Many evidence has shown that chemotherapy can reduce neurotransmitter production and release in brain tissues ( Fitzgerald, 2021 ; Rao et al, 2022 ). As we know, Ach, a key cholinergic neurotransmitter, can sustain brain function by regulating long-term potentiation.…”