Norepinephrine and histamine potentiate the increases in cyclic adenosine 3':5'-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by alpha 1- adrenergic and H1-histaminergic receptors

Magistretti, P. J.; Schorderet, Michel

doi:10.1523/jneurosci.05-02-00362.1985

Cited by 82 publications

(24 citation statements)

References 2 publications

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“…Other receptors having no direct linkage to the cyclase e.g. al-adrenoceptors, histamine HI, GABAB, somatostatin receptors (Magistretti & Schoreret, 1984;Sherer et al, 1988;Rougon et al, 1983) can act synergistically with directly-coupled receptors to enhance cyclic nucleotide formation and thereby act as positive neuromodulators.…”

Section: Introductionmentioning

confidence: 99%

Direct and indirect stimulations of cyclic AMP formation in human brain

Kendall

Millns

Firth

1992

British J Pharmacology

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1 Adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation, by use of an [3H]-adenine prelabelling assay, was measured in fragments of human cerebral cortex, taken in the course of various neurosurgical procedures. 2 Large accumulations of [3H]-cyclic AMP due to isoprenaline, noradrenaline and adenosine and small effects due to forskolin were observed. Histamine, 5-hydroxytryptamine (5-HT) and the excitatory amino acids glutamate and quisqualate were ineffective.3 The response to noradrenaline consisted of two components; a direct P-adrenoceptor response and an enhancement mediated by an a-adrenoceptor which appears to be similar to that in rat cerebral cortex.4 The response to isoprenaline was also potentiated by histamine H, receptor stimulation but the direct effect of 2-chloroadenosine was not altered by histamine, 5-HT or quisqualate. 5 It is concluded that some, but not all, of the indirect modulations of cyclic AMP formation previously observed in experimental animal brain exist in human cerebral cortex.

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Section: Introductionmentioning

confidence: 99%

Direct and indirect stimulations of cyclic AMP formation in human brain

Kendall

Millns

Firth

1992

British J Pharmacology

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“…Comparable re sults have been reported for the rat [Lidov et al, 1980] and monkey [Kosofsky et al, 1984;Takeuchi and Sano, 1983]. Since monoaminergic axons tend to course tangentially in the neocortex, it has been suggested that they influence multiple areas in a global way and that their effect on a specific region depends upon activity induced by other inputs [Magistretti and Schorderet, 1985;Morrison and Magi stretti, 1983].…”

Section: Discussionmentioning

confidence: 87%

Serotonergic Innervation of the Forebrain in the North American Opossum; pp. 213–228

Martin¹,

DeLorenzo²,

Ho³

et al. 1985

Brain Behav Evol

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The forebrain distribution of axons showing serotonin-like immunoreactivity was studied in the North American opossum. Serotonergic innervation of the hypothalamus was extensive, particularly within the ventromedial nucleus, the periventricular nucleus and the rostral supraoptic nucleus. Serotonergic axons were also present within the fields of Forel and zona incerta, but they tended to avoid parts of the subthalamic nucleus. In the thalamus serotonergic innervation was dense within the midline nuclei (e.g. the central, intermediate dorsal and rhomboid nuclei) and the ventral lateral geniculate nucleus, but relatively sparse in some of the nuclei more readily associated with specific functions (e.g. the ventrobasal nucleus). Serotonergic axons innervate most areas of the rostral and dorsal forebrain. Areas containing the heaviest innervation included the interstitial nucleus of the stria terminalis and the lateral septal nucleus. Serotonergic innervation of the neocortex varied markedly from region to region and within different layers of the same regions. The retrograde transport of True Blue combined with immunofluorescence for localization of serotonin revealed that serotonergic axons within the forebrain arise mainly within the dorsal raphe and superior central nuclei, but that some originate within the midbrain and pontine reticular formation and the locus coeruleus, pars alpha. Neurons of the raphe magnus and obscurus also innervate the forebrain, but few of them are serotonergic. The use of horseradish peroxidase as a retrograde marker provided evidence that raphe projections to the forebrain are topographically organized. Our results suggest that serotonergic projections to the forebrain, like those to the spinal cord, are connectionally heterogeneous.

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“…adenosine A2) which is linked directly to the cyclic AMP synthesizing enzyme, adenylate cyclase (AlGadi produces a large augmentation of the cyclic AMP response to the selective H2-agonist impromidine, or of that produced by adenosine, but is without effect on the cyclic AMP generating system on its own (Al-Gadi & Hill, 1985). A similar H,-mediated augmentation of the response to H2-agonists, adenosine or vasoactive intestinal polypeptide (VIP) has also been reported in slices of mouse cerebral cortex (Magistretti & Schorderet, 1985), guinea-pig hippocampus (Palacios et al, 1978) and guinea-pig cerebral cortex (Hill et al, 1981;Daum et al, 1982;. Since it is not possible to detect an H,-effect in membrane fractions of guinea-pig hippocampus and cerebral cortex (Hegstrand et al, 1976;Green et al, 1977;Hough et al, 1980;Kanof & Greengard, 1979), it seems likely that these indirect cyclic AMP responses to histamine are mediated by another second messenger such as calcium ions (Schwabe et al, 1978) or diacylglycerol .…”

Section: Introductionmentioning

confidence: 75%

The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices

Al-Gadi

Hill

1987

British J Pharmacology

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1The effect of calcium on the H,-and H2-receptor components of the cyclic AMP response to histamine in rabbit cerebral cortical slices has been investigated. 2 Removal of calcium ions from the incubation medium during the preparation, preincubation and final incubation of brain slices significantly reduced the cyclic AMP responses to adenosine, histamine and the H2-selective agonist, impromidine. 3 Removal of calcium ions from the incubation medium during only the final incubation with agonists did not influence the responses to adenosine, histamine, impromidine and the H,-selective agonist, 2-thiazolylethylamine. 4 Final incubation of rabbit cerebral cortical slices in calcium-free buffer containing EGTA (I mM) however, selectively reduced the cyclic AMP responses to the H,-agonists histamine and 2-thiazolylethylamine without affecting the response to impromidine or adenosine. 5 These latter incubation conditions significantly reduced the maximal extent of the augmentation of impromidine-or adenosine-stimulated cyclic AMP accumulation produced by H,-receptor stimulation, without affecting the EC, values of the H,-agonists. Calcium-free/EGTA conditions did not, however, alter the dose-response parameters for the response to the H2-agonist, impromidine. 6 These data provide further evidence that the two histamine receptor systems affect cyclic AMP accumulation in rabbit cerebral cortical slices by different mechanisms.

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Norepinephrine and histamine potentiate the increases in cyclic adenosine 3':5'-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by alpha 1- adrenergic and H1-histaminergic receptors

Cited by 82 publications

References 2 publications

Direct and indirect stimulations of cyclic AMP formation in human brain

Direct and indirect stimulations of cyclic AMP formation in human brain

Serotonergic Innervation of the Forebrain in the North American Opossum; pp. 213–228

The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices

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