Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse

Lambert, Joshua D.; Zhao, Dedun; Meyers, Ross O.; Kuester, Robert K.; Timmermann, Barbara N.; Dorr, Robert T.

doi:10.1016/s0041-0101(02)00203-9

Cited by 69 publications

(54 citation statements)

References 18 publications

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“…PSMs that are ingested and absorbed enter the general circulation where they can be distributed to various tissues and organs. The accumulation of PSMs in tissues and organs can have severe physiological consequences such as lesions, cysts, metabolic acidosis and death (Grice et al 1968;Jha and Chugh 2003;Koppel et al 1981;Lambert et al 2002;Majak 1992;Robles et al 1998). The severity of the physiological consequences induced by PSMs is dependent on the concentration of PSMs that accumulate in the tissues (Paumgartten et al 1990;Sperling et al 1967).…”

Section: Introductionmentioning

confidence: 99%

Plant secondary metabolites alter the feeding patterns of a mammalian herbivore (Neotoma lepida)

2005

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Mammalian herbivores are predicted to regulate concentrations of ingested plant secondary metabolites (PSMs) in the blood by modifying the size and frequency of feeding bouts. It is theorized that meal size is limited by a maximum tolerable concentration of PSMs in the blood, such that meal size is predicted to decrease as PSM concentration increases. We investigated the relationship between PSM concentration in the diet and feeding patterns in the herbivorous desert woodrat (Neotoma lepida) fed diets containing phenolic resin extracted from creosote bush (Larrea tridentata). Total daily intake, meal size and feeding frequency were quantified by observing the foraging behavior of woodrats on diets containing increasing concentrations of creosote resin. Desert woodrats reduced meal size as resin concentration in the diet increased, resulting in an overall reduction in daily intake and regulation of resin intake. Moreover, desert woodrats were able to detect resin concentrations in the diet and regulate the intake of resin very rapidly. We suggest that the immediate and sustained ability to detect and regulate the intake of resin concentrations during each foraging bout provides a behavioral mechanism to regulate blood concentrations of resin and allows desert woodrats to make "wise" foraging decisions.

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Section: Introductionmentioning

confidence: 99%

Plant secondary metabolites alter the feeding patterns of a mammalian herbivore (Neotoma lepida)

2005

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“…NDGA is a polyphenol compounds that was used before, for its antioxidant activity, in the conservation of fats and butter, in high concentrations, which are related to hepatotoxicity. The concentrations of NDGA related to hepatotoxicity are in order to 50-100 µM (15-30 µg/ml) or more [39,40]. In contrast, low concentrations of NDGA are related to beneficial properties which are of potential use for humans such as, enzyme inhibitor, antimicrobial activity properties, a protector from neurotoxicity and bladder toxicity [41], anticancer and antimutagenic action [42].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Micucci¹,

Alonso²,

Turner³

et al. 2011

FNS

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“…Oncologists remain hesitant to recommend the high doses of NDGA that would be needed to obtain the results of alternative treatments because of its hepatotoxic effects (Lambert and Zhao, 2002).…”

Section: Cellular Proliferation Of Mmt Cells Exposed To Individual Drugsmentioning

confidence: 99%

Students Investigating the Antiproliferative Effects of Synthesized Drugs on Mouse Mammary Tumor Cells

Hammamieh

Anderson²,

Carr³

et al. 2005

CBE

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The potential for personalized cancer management has long intrigued experienced researchers as well as the naïve student intern. Personalized cancer treatments based on a tumor's genetic profile are now feasible and can reveal both the cells' susceptibility and resistance to chemotherapeutic agents. In a weeklong laboratory investigation that mirrors current cancer research, undergraduate and advanced high school students determine the efficacy of common pharmacological agents through in vitro testing. Using mouse mammary tumor cell cultures treated with ''unknown'' drugs historically recommended for breast cancer treatment, students are introduced to common molecular biology techniques from in vitro cell culture to fluorescence microscopy. Student understanding is assessed through laboratory reports and the successful identification of the unknown drug. The sequence of doing the experiment, applying logic, and constructing a hypothesis gives the students time to discover the rationale behind the cellular drug resistance assay. The breast cancer experiment has been field tested during the past 5 yr with more than 200 precollege/undergraduate interns through the Gains in the Education of Mathematics and Science program hosted by the Walter Reed Army Institute of Research.

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Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse

Cited by 69 publications

References 18 publications

Plant secondary metabolites alter the feeding patterns of a mammalian herbivore (Neotoma lepida)

Plant secondary metabolites alter the feeding patterns of a mammalian herbivore (Neotoma lepida)

Antioxidant and Antimicrobial Activities of Larrea Divaricata Cav. Aqueous Extract on Vitamin C from Natural Orange Juice

Students Investigating the Antiproliferative Effects of Synthesized Drugs on Mouse Mammary Tumor Cells

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