Noradrenergic and dopaminergic involvement in novelty modulation of aversive memory generalization of adult rats

Lima, Karine Ramires; Vargas, Liane da Silva de; Ramborger, Bruna Piaia; Roehrs, Rafael; Sevenster, Dieuwke; Izquierdo, Iván; D’Hooge, Rudi; Mello‐Carpes, Pâmela Billig

doi:10.1016/j.bbr.2019.111991

Cited by 12 publications

(6 citation statements)

References 40 publications

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“…Studies demonstrated that 5 min exploring a new environment increase immediately dopamine levels in the hippocampus (Lima et al, 2019; Menezes et al, 2015). Furthermore, studies that applied pharmacological dopamine stimulators in the same time window revealed NOR memory persistence after that (Lima et al, 2021; Neves et al, 2020; Vargas et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…The infusion procedures were based on previous studies by our research group (Lima et al, 2019; Lima et al, 2021; Menezes et al, 2015; Neves et al, 2020; Vargas et al, 2020). For the infusion, a Hamilton syringe was connected to fine bore polythene tubing (38 gauge) with an infusion needle (30 gauge) at the end.…”

Section: Methodsmentioning

confidence: 99%

“…Novelty exposure induces dopamine release in the hippocampus (Lima et al, 2019; Menezes et al, 2015), primarily by neurons that project from the ventral tegmental area (VTA) (Lisman & Grace, 2005) and the locus coeruleus (LC) (Takeuchi et al, 2016). This event is critical to triggering the synthesis of PRPs (Moncada et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Lima

Rosa

Picua

et al. 2021

Eur J of Neuroscience

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Strategies for improving memory are increasingly studied, and exposure to a novel experience can be an efficient neuromodulator. Novelty effects on memory depend on D1‐family dopamine receptors (D1Rs) activation. Here, we evaluated the novelty effect on memory persistence of Wistar rats and investigated the contribution of D1Rs and their signalling pathways by protein kinase A (PKA) and C (PKC). Animals with infusion cannulae inserted into the CA1 hippocampus area were trained on the novel object recognition (NOR) task, which involved exploring two different objects. After training, some rats received intrahippocampal infusions of vehicle or D1Rs agonist; others explored a novel environment for 5 min and were infused with a variety of drugs targeting D1Rs and their signalling pathways. We demonstrated that pharmacological stimulation of D1Rs or novelty exposure promoted NOR memory persistence for 14 days and that the novelty effect depended on D1Rs activation. To determine if the D1 and D5 receptor subtypes were necessary for the impact of novelty exposure on memory, we blocked or stimulated PKA or PKC—protein kinases activated mainly by D1 and D5, respectively. Only PKA inhibition impaired the effect of novelty on memory persistence. After novelty and D1Rs blocking, PKA but not PKC stimulation maintained the memory persistence effect. Thus, we concluded that novelty promoted memory persistence by a mechanism‐dependent on activating hippocampal D1Rs and PKA pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Lima

Rosa

Picua

et al. 2021

Eur J of Neuroscience

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“…The time exploring the new rat and the familiar rat was registered. Exploring the animal was defined as smelling or touching the cages with the nose or front legs [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of strength training in a neuroinflammatory animal model

et al. 2022

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Background The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus. Methods The animals received muscular strength training (SE) three times a week for eight weeks. Subsequently, the stereotaxic surgery was performed with an intra-hippocampal infusion of either saline solution (SAL) or lipopolysaccharide (LPS). Next, we performed the behavioral tests: object recognition and social recognition. Then, the animals were euthanized, and their hippocampus and prefrontal cortex were collected. In another moment, we performed the dosage of the antioxidant activity and histological analysis. Results The results showed that the muscular strength exercises could show a beneficial prophylactic effect in the cognitive deficiencies caused by acute neuroinflammation. Regarding oxidative stress, there was an increase in catalase enzyme activity (CAT) in the group (SE + LPS) compared to the control groups (p < 0.05). As for the cognitive alterations, there were found in the (SE + LPS) group, diminishing the mnemonic hazard of the discriminative and social memories compared to the control groups (p < 0.05). Conclusion We concluded, therefore, that the exercise performed prophylactically presents a protective effect capable of minimizing such mnemonic deficits and increasing catalase enzyme activity in rats that suffered a local neuroinflammatory process in the hippocampus.

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“…The exploration of the animal was defined as smelling or touching the cages with the nose and/or front legs [19].…”

Section: Social Recognition Memory Testmentioning

confidence: 99%

Neuroprotector Effect Of Strength Training In An Neuroinflammation Animal Model

Gregorio

Mendes

Somensi

et al. 2021

Preprint

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Background: The preventive role of muscular strength in the diminishing of a neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated, whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammation model of the CA1 region of the hippocampus. Methods: The animals received muscular strength training for eight weeks, three times a week. Subsequently, the stereotaxic surgery, with intra-hippocampal infusion of either saline solution or l ipopolysaccharide (LPS) was performed. Next, behavioral tests were performed: objects and social recognition. At last, the animals were euthanized and the collect of the hippocampus and the prefrontal cortex were performed and, later, the dosage of the antioxidant activity was performed. Results: The results showed that the muscular strength exercises was capable of showing a beneficial prophylactic effect in the oxidative stress caused by an acute neuroinflammation. There was diminishing of the reduced glutathione concentration (GSH) and increase of the activity of the catalase enzyme (CAT) in the group (SE + LPS), regarding the control groups. In the prefrontal cortex, there was only an increase of the CAT activity in the group (SE + LPS), regarding the groups (CT) and (SE + SAL). As for the cognitive alterations there were found in the (SE + LPS) group, diminishing the mnemonic hazard of the discriminative and social memories, when compared to the control groups. Conclusion: We concluded, therefore, that the induction of a local inflammatory process in the hippocampus leads to mnemonic deficits in behavioral activities and increase of the GSH concentration, and that the muscular strength exercise performed prophylactically presents a protective effect capable of minimizing such mnemonic deficits and increasing the antioxidant defenses in mice that suffered a local neuroinflammatory process in the hippocampus.

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Noradrenergic and dopaminergic involvement in novelty modulation of aversive memory generalization of adult rats

Cited by 12 publications

References 40 publications

Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Novelty promotes recognition memory persistence by D1 dopamine receptor and protein kinase A signalling in rat hippocampus

Neuroprotective effects of strength training in a neuroinflammatory animal model

Neuroprotector Effect Of Strength Training In An Neuroinflammation Animal Model

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