Noradrenaline, Dopamine, Serotonin: Different Effects of Psychological Stress on Brain Biogenic Amines in Mice and Rats

Konstandi, Maria; Johnson, Elizabeth O.; Lang, Matti A.; Malamas, Michalis; Marselos, Marios

doi:10.1006/phrs.1999.0597

Cited by 66 publications

(38 citation statements)

References 19 publications

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“…Stressrelated behavioral paradigms, such as conditioned fear, increase 5-HT metabolism and release in the medial prefrontal cortex, nucleus accumbens, amygdala, and dorsal hippocampus (Inoue et al, 1994;Ge et al, 1997;Konstandi et al, 2000). In particular, restraint stress increases 5-HT turnover in the hypothalamus and amygdala in mice and rats (Konstandi et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Hypothalamic-pituitary-adrenal axis hormones have been suggested to be involved in this stress response, at least in part, via the release of 5-HT in the medial prefrontal cortex, nucleus accumbens, amygdala, and dorsal hippocampus (Inoue et al, 1994;Ge et al, 1997;Konstandi et al, 2000). Only one study proposed that 5-HT 2A/2C receptors could be involved in this cascade of events (Grignaschi et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Compan¹,

Zhou²,

Grailhe³

et al. 2004

J. Neurosci.

155

111

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To study the functions of 5-HT 4 receptors, a null mutation was engineered in the corresponding gene. 5-HT 4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT 4 receptors may be involved in stress-induced anorexia and seizure susceptibility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Compan¹,

Zhou²,

Grailhe³

et al. 2004

J. Neurosci.

155

111

View full text Add to dashboard Cite

show abstract

“…The involvement of brain monoamines in response to stress has been widely investigated (Bliss et al 1968;Konstandi et al 2000) and both 5-HT (Courzon 1971;Petty et al 1992;Chaouloff 2000) and DA (Pani et al 2000) are considered to play a crucial role in coping with stressful situations. Dopaminergic neurons in the ventral tegmental area are rapidly activated by sudden environmental events, including stressful circumstances (Kaneyuki et al 1991), and acute exposure to different forms of stress has been reported to increase DA release in the PFC (Sorg and Kalivas 1993;Finlay et al 1995;Yoshioka et al 1996) as well as in the NAc (Rouge-Pont et al 1993;Kalivas and Duffy 1995;Tidey and Miczek 1996).…”

Section: Discussionmentioning

confidence: 99%

Effects of Long-term Acetyl-L-carnitine Administration in Rats I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure

Tolu

2002

Neuropsychopharmacology

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“…Stress and anxiety can also induce anorexia (13), and increases in 5-HT neuromodulation are known to participate in the decreased food intake caused by stress (14)(15)(16). We have demonstrated that 5-HT 4 R KO displays attenuated responses to stress-induced hypophagia (17).…”

mentioning

confidence: 99%

Anorexia induced by activation of serotonin 5-HT ₄ receptors is mediated by increases in CART in the nucleus accumbens

Jean

Conductier

Manrique

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

176

142

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Anorexia nervosa is a growing concern in mental health, often inducing death. The potential neuronal deficits that may underlie abnormal inhibitions of food intake, however, remain largely unexplored. We hypothesized that anorexia may involve altered signaling events within the nucleus accumbens (NAc), a brain structure involved in reward. We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT4R) in the NAc reduces the physiological drive to eat and increases CART (cocaine-and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice. It further shows that injecting 5-HT4R antagonist or siRNA-mediated 5-HT4R knockdown into the NAc induced hyperphagia only in fed mice. This hyperphagia was not associated with changes in CART mRNA expression in the NAc in fed and food-deprived mice. Results include that 5-HT4R control CART mRNA expression into the NAc via a cAMP/PKA signaling pathway. Considering that CART may interfere with food-and drug-related rewards, we tested whether the appetite suppressant properties of 3,4-N-methylenedioxymethamphetamine (MDMA, ecstasy) involve the 5-HT4R. Using 5-HT4R knockout mice, we demonstrate that 5-HT4R are required for the anorectic effect of MDMA as well as for the MDMA-induced enhancement of CART mRNA expression in the NAc. Directly injecting CART peptide or CART siRNA into the NAc reduces or increases food consumption, respectively. Finally, stimulating 5-HT4R-and MDMA-induced anorexia were both reduced by injecting CART siRNA into the NAc. Collectively, these results demonstrate that 5-HT4R-mediated upregulation of CART in the NAc triggers the appetite-suppressant effects of ecstasy.A norexia nervosa is one of the mental diseases exhibiting the highest mortality rates in industrialized countries (1, 2). No effective strategies for treating this disorder are available. If one defines anorexia as self-imposed deprivation despite an energy demand, similar behavior can be provoked by treatments that increase serotonin (5-hydroxytryptamine, 5-HT) neuromodulation (3). For instance, fenf luramine, which increases synaptic 5-HT levels, lowers the consumption of food in humans and rodents (4, 5). Similarly, amphetamine and 3,4-N-methylenedioxymethamphetamine (MDMA, ecstasy) diminish food consumption in humans (6) and rats (7) and reduce deprivation-induced eating in mice (8). 5-HTinduced hypophagia is mediated by both 5-HT 1B and 5-HT 2C receptors (5-HT 1B R and 5-HT 2C R) (9 -11). In particular, 5-HT 2C R in the hypothalamus contributes to fenf luramineand MDMA-induced anorexia-like behavior (5, 8, 12). Moreover, 5-HT 1B R and 5-HT 2C R knockout (KO) mice are less sensitive to fenf luramine (4, 5).Stress and anxiety can also induce anorexia (13), and increases in 5-HT neuromodulation are known to participate in the decreased food intake caused by stress (14-16). We have demonstrated that 5-HT 4 R KO displays attenuated responses to stress-induced hypophagia (17). Because MDMA is a rewarding drug that reduces the intake of food...

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Noradrenaline, Dopamine, Serotonin: Different Effects of Psychological Stress on Brain Biogenic Amines in Mice and Rats

Cited by 66 publications

References 19 publications

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Effects of Long-term Acetyl-L-carnitine Administration in Rats I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure

Anorexia induced by activation of serotonin 5-HT ₄ receptors is mediated by increases in CART in the nucleus accumbens

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Noradrenaline, Dopamine, Serotonin: Different Effects of Psychological Stress on Brain Biogenic Amines in Mice and Rats

Cited by 66 publications

References 19 publications

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT4Receptor Knock-Out Mice

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT4Receptor Knock-Out Mice

Effects of Long-term Acetyl-L-carnitine Administration in Rats I. Increased Dopamine Output in Mesocorticolimbic Areas and Protection toward Acute Stress Exposure

Anorexia induced by activation of serotonin 5-HT 4 receptors is mediated by increases in CART in the nucleus accumbens

Contact Info

Product

Resources

About

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT₄Receptor Knock-Out Mice

Anorexia induced by activation of serotonin 5-HT ₄ receptors is mediated by increases in CART in the nucleus accumbens