Nootropics, Functional Foods, and Dietary Patterns for Prevention of Cognitive Decline

Bonetti, Francesco; Brombo, Gloria; Zuliani, Giovanni

doi:10.1016/b978-0-12-805376-8.00019-8

Cited by 30 publications

(23 citation statements)

References 216 publications

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“…Luteolin in the liposomal form in olive fruit extract enhanced attention in kids with autism spectrum illnesses and brain fog in patients with mild cognitive consequences. Chrysin, a flavone found in multiple vegetables, fruits and mushrooms, has been suggested as a neurotrophic for nervous cells, anti-inflammatory and anti-amyloidogenic [ 170 ]. In addition, it also reduces the signs of DSS-induced colitis in mice by considerably diminishing colonic myeloperoxidase activity and decreasing proinflammatory cytokine, prostaglandin E 2 (PGE2) and nitric oxide (NO) output [ 171 ].…”

Section: Main Bodymentioning

confidence: 99%

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

2021

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Background Natural plants and plant-derived formulations have been used by mankind from the ancient period of time. For the past few years, many investigations elaborated the therapeutic potential of various secondary chemicals present in the plants. Literature revealed that the various secondary metabolites, viz. phenolics and flavonoids, are responsible for a variety of therapeutic action in humans. Main body In the present review, an attempt has been made to compile the exploration of natural phenolic compounds with major emphasis on flavonoids and their therapeutic potential too. Interestingly, long-term intake of many dietary foods (rich in phenolics) proved to be protective against the development and management of diabetes, cancer, osteoporosis, cardiovascular diseases and neurodegenerative diseases, etc. Conclusion This review presents an overview of flavonoid compounds to use them as a potential therapeutic alternative in various diseases and disorders. In addition, the present understanding of phenolics and flavonoids will serve as the basis for the next scientific studies.

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Section: Main Bodymentioning

confidence: 99%

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

2021

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“…The addition of three molecules of malonyl-CoA to 4-coumaroylCoA leads to the synthesis of a bicyclic chalcone, such as naringenin chalcone, which is the precursor of flavanones, which in turn, are the precursors for all the rest of flavonoids. [48][49][50][51] The presence of different enzymes in plants such as isomerases, reductases, hydrolases and dioxygenases introduces modifications in the basic flavonoid structure, leading to the diverse flavonoids subclasses, 52 including: antoxanthins (flavones and flavonols), 45,[53][54][55][56][57] flavanones, 45,54,58,59 flavanonols, 60 isoflavonoides, 45,61,62 flavanols or catechins, 45,[63][64][65][66] anthocyanidins [67][68][69][70] and chalcones 59,71,72 (Figures 1-3). There are many examples of flavonoids found in plants with modifications in their structure, mainly as sugar O-conjugates in different positions.…”

Section: Classification Of Polyphenolsmentioning

confidence: 99%

Insight into the potential application of polyphenol-rich dietary intervention in degenerative disease management

et al. 2020

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“…Flavanols, also referred to as flavan-3-ols or catechins, are present in high concentrations in cocoa, grapes, tea [ 58 ] and red wine [ 59 ].…”

Section: Diabetic Retinopathy and The Benefits Of Flavonoidsmentioning

confidence: 99%

The Benefits of Flavonoids in Diabetic Retinopathy

et al. 2020

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Diabetic retinopathy (DR), one of the most common complications of diabetes, is the leading cause of legal blindness among adults of working age in developed countries. After 20 years of diabetes, almost all patients suffering from type I diabetes mellitus and about 60% of type II diabetics have DR. Several studies have tried to identify drugs and therapies to treat DR though little attention has been given to flavonoids, one type of polyphenols, which can be found in high levels mainly in fruits and vegetables, but also in other foods such as grains, cocoa, green tea or even in red wine. Flavonoids have anti-inflammatory, antioxidant and antiviral effects. Since it is known that diabetes induces oxidative stress and inflammation in the retina leading to neuronal death in the early stages of the disease, the use of these compounds can prove to be beneficial in the prevention or treatment of DR. In this review, we summarize the molecular and cellular effects of flavonoids in the diabetic retina.

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Nootropics, Functional Foods, and Dietary Patterns for Prevention of Cognitive Decline

Cited by 30 publications

References 216 publications

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

Flavonoids as natural phenolic compounds and their role in therapeutics: an overview

Insight into the potential application of polyphenol-rich dietary intervention in degenerative disease management

The Benefits of Flavonoids in Diabetic Retinopathy

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