Nootropic drugs have different effects on kindling-induced learning deficits in rats

Becker, Axel; Grecksch, Gisela

doi:10.1016/s1043-6618(05)80003-9

Cited by 6 publications

(10 citation statements)

References 16 publications

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“…A Saline controls and B PTZ-kindled animals after a challenge dose of 20 mg PTZ/kg without (solid line) and with (broken line) pretreatment of 100 mg piracetam/kg 1 h before PTZ injection followed (experiment II). Amplitude deviations are expressed as difference (∆ mV) to control values before PTZ or piracetam and PTZ injection (median and standard error of median; MannWhitney U-test; *P<0.05) stance prevents a learning deficit induced by the kindling procedure (Becker and Grecksch 1995b) and it also depresses the development of a novel form of kindling-induced potentiation (KIP), the long-lasting enhancement of field potentials in the dentate gyrus of kindled rats after application of a subconvulsive challenge dose of PTZ (Rüthrich et al 1996). However, piracetam has no effect on the development and occurrence of seizures in the course of PTZ kindling.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, these results indicate that motor seizures did not necessarily correlate with diminished learning performance in an active avoidance task (Becker et al 1992). However, the kindling-induced learning deficits can be reduced by different treatments with different influences on seizure development including gangliosides (Grecksch et al 1991), antiepileptic drugs (Becker et al 1995), calcium antagonists (Becker and Grecksch 1995a), and nootropic drugs (Becker and Grecksch 1995b).…”

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 91%

“…In preliminary studies we have demonstrated that piracetam at a dose of 100 mg/kg i.p. was effective in counteracting the kindling-induced learning deficit, but did not interfere with PTZ kindling seizures or development of kindling (Becker and Grecksch 1995b).…”

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 96%

“…A comparison of the effects of the nootropic drug piracetam on both phenomena should answer the question whether the PTZ kindling-induced potentiation is related to the impairment of learning performance and whether kindlinginduced potentiation and the learning deficits can be similarly influenced by the standard nootropic drug piracetam. It was the aim of the present study to investigate the effect of piracetam on the PTZ kindling-induced potentiation at a dosage at which an improvement in learning functions was evident (Becker and Grecksch 1995b).…”

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 99%

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Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit

Rüthrich

Grecksch

Krug

1999

Naunyn-Schmiedeberg's Arch Pharmacol

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Kindling is a generally accepted model for studying epilepsy development in the context of overexpression of processes of neuronal plasticity. In previous studies we have shown that establishment of kindling by repeated application of subconvulsive doses of pentylenetetrazol (PTZ) also led to marked changes in hippocampal excitability and an impairment in learning behaviour. With the intention of further investigating the relationship between kindling development, kindling-induced changes in excitability and learning deficits, rats were chemically kindled under pretreatment with the nootropic drug piracetam. Furthermore, we tested acute piracetam effects on developed kindling seizures, the learning deficit and potentiation effects. At the investigated dose piracetam did not influence the kindling development. The kindling-induced potentiation of hippocampal field potentials was significantly diminished in piracetam-pretreated rats. Piracetam acutely injected completely antagonized this potentiation effect. Piracetam brought about a significant improvement in impaired learning performance in rats pretreated during kindling induction and acutely injected before the learning experiment, respectively. Possible correlations between the suppressing of the kindling related potentiation in hippocampal structures by piracetam and its beneficial effect on learning impairment are discussed as antagonizing overexpression of potentiation in the course of kindling.

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Section: Discussionmentioning

confidence: 99%

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 91%

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 96%

Section: Heinz Rüthrich · Gisela Grecksch · Manfred Krugmentioning

confidence: 99%

See 2 more Smart Citations

Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit

Rüthrich

Grecksch

Krug

1999

Naunyn-Schmiedeberg's Arch Pharmacol

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“…For kindling, a dose of 37.5 mg/kg body weight PTZ (ED 16 related to clonic seizures established in a separate group of animals) was injected ip once every 48 h. Immediately after each injection, the convulsive behavior was observed for 20 min. The resultant seizures were classified according to a modified Racine scale as follows (Becker et al, 1995; Becker and Grecksch, 1995).…”

Section: Methodsmentioning

confidence: 99%

Pentylenetetrazole Kindling Affects Sleep in Rats

et al. 2006

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Summary:Purpose: The aim of the study was to define sleep disturbances in pentylenetetrazole (PTZ)-kindled rats and to explore the effects of the nootropic drug piracetam (Pir; 100 mg/kg) and the noncompetitive N-methyl-D-aspartate (NMDA)-antagonist MK-801 (0.3 mg/kg), which normalized learning performance in PTZ-kindled rats, on altered sleep parameters.Methods: This is the first report showing a significant reduction in paradoxical sleep (PS) as a consequence of PTZ kindling. A correlation analysis revealed a significant correlation between seizure severity and PS deficit.Results: Pir did not interfere with seizure severity, and the substance did not ameliorate the PS deficit. However, the substance disconnected the correlation between seizure severity and PS deficit. MK-801, which reduced the severity of kindled seizures, counteracted the PS deficit efficaciously.Conclusions: The results suggest that seizure severity and alterations in sleep architecture are two factors in the comprehensive network underlying learning impairments associated with epilepsy. Considering the results obtained in the experiments with Pir, reduction of seizure severity does not guarantee the reduction of impairments in the domain of learning. Key Words: Epilepsy-Kindling-Learning-SleepPentylenetetrazole-Piracetam-MK-801-Rat.A body of evidence suggests that epilepsy can result in cognitive impairments leading to lowered educational and occupational levels of achievement. It was suggested that a plethora of multiple factors such as seizure type, seizure severity and frequency, seizure duration, and age at seizure onset underlie cognitive impairments associated with epilepsy (Lesser et al., 1986;Dodrill, 1992;Kalviainen et al., 1992;Devinsky, 1995;Aldenkamp et al., 1996;Vuilleumier et al., 1996;Aldenkamp et al., 2001;Samson 2002;Duncan and Thompson, 2003;Helmstaedter et al., 2003;Nolan et al., 2003;2004;Dodrill, 2004;Sonmez et al., 2004).The mechanism underlying these impairments is an object of debate and controversy. It was shown that sleep affects epileptic activity and vice versa. In epilepsy patients, altered sleep-wake cycles and an increased number of stage shifts were found. Moreover, quantitative aspects of different sleep stages were reported to be changed (Autret et al

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Vinpocetine inhibits the epileptic cortical activity and auditory alterations induced by pentylenetetrazole in the guinea pig in vivo

Nekrassov

Sitges

2004

Epilepsy Research

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Nootropic drugs have different effects on kindling-induced learning deficits in rats

Cited by 6 publications

References 16 publications

Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit

Effects of piracetam on pentylenetetrazol-kindling development, hippocampal potentiation phenomena and kindling-induced learning deficit

Pentylenetetrazole Kindling Affects Sleep in Rats

Vinpocetine inhibits the epileptic cortical activity and auditory alterations induced by pentylenetetrazole in the guinea pig in vivo

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