Nonylphenol in pregnant women and their matching fetuses: Placental transfer and potential risks of infants

Huang, Yu Fang; Wang, Pei Wei; Huang, Liying; Yang, Winnie; Yu, Ching Jung; Yang, Shang Han; Chiu, Hsin Hao; Chen, Mei Lien

doi:10.1016/j.envres.2014.07.004

Cited by 60 publications

(20 citation statements)

References 49 publications

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“…Humans may be exposed to NP through drinking water; the intake of contaminated foods; the inhalation of air; and absorption via the skin [ 6 , 16 ]. NP is widespread in Taiwanese food, and the average daily intake of NP is 4- to 8.5-fold higher than that in other countries [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children

Yu¹,

Chiou

et al. 2016

PLoS ONE

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ObjectiveNonylphenol (NP) belongs to the family of endocrine disruptors, and it is widely used in industrial applications and is ubiquitous in daily foods. Animal studies have suggested that NP exposure might promote motor hyperactivity, likely by causing deficits in dopaminergic neurons. However, research assessing NP exposure and epidemiology studies on human populations are limited. The aim of this study was to explore the association between child NP exposure and ADHD while considering particular covariants, such as lead levels and dopamine-related gene variations.MethodsA case-control study was conducted on patients with clinically diagnosed ADHD; the Swanson, Nolan and Pelham, Fourth Revision (SNAP-IV) questionnaire was used to identify normal controls aged 4–15 years. Participants were examined for urinary NP concentrations, blood lead levels, and select single-nucleotide polymorphisms of two dopamine-related genes (D4 dopamine receptor, DRD4, and dopamine transporter, DAT1). Socio-demographic variables, maternal lifestyle factors during pregnancy and family medical history were obtained using a questionnaire.ResultsA total of 97 children with doctor-diagnosed ADHD and 110 normal controls were enrolled. The blood lead levels in both groups were similar (1.57±0.73 vs. 1.73±0.77 μg/dL, p = 0.15). No significant difference in urinary NP concentration was found between the children with ADHD and the control subjects (4.52±3.22 μg/g cr. vs. 4.64±2.95 μg/g cr., p = 0.43). ADHD was significantly more prevalent among males in this study (male to female ratio: 5:1 for the ADHD group and 1.3:1 for the control group, p<0.01). The analysis was repeated after excluding the females, but this had no effect on the association between NP and ADHD. The regression model, including or excluding females, indicated no increased odds of having ADHD in the context of NP exposure after adjusting for covariants.ConclusionThis study indicated that NP exposure might not promote ADHD in children, even though children in Taiwan had relatively high levels of NP compared to those reported previously and those in developed nations.

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Section: Introductionmentioning

confidence: 99%

Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children

Yu¹,

Chiou

et al. 2016

PLoS ONE

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“…Humans are exposed to these compounds through inhalation, ingestion of contaminated food, and dermal absorption. Concentrations up to 200 ng/g NP (approximately 1 mM) and 1.15 ng/ml OP (approximately 0.006 mM) have been reported in blood, umbilical cord, and placenta (Azzouz et al, 2016;Chen et al, 2008;Huang et al, 2014;Tan and Mohd, 2003). Both compounds can accumulate in lipids, bind to proteins, cause acute cytotoxicity, oxidative stress, and act as endocrine disrupters (Bonefeld-Jørgensen et al, 2007;Kim et al, 2015;Lepretti et al, 2015;P erez-Albaladejo et al, 2017;Soto et al, 1991;Xie et al, 2013).…”

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confidence: 99%

Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition

Pérez-Albaladejo

Lacorte

Porte

2018

Toxicological Sciences

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Alkylphenols (APs) are a diverse class of chemicals that can cross the placental barrier and interfere with embryonic and fetal development. This work investigates the comparative toxicity, ability to inhibit aromatase activity, and to alter the lipid composition of 10 alkylphenols in the human placenta choriocarcinoma cell line JEG-3. Among the selected APs, 4dodecylphenol (DP), 4-heptylphenol (HP), and 4-cumylphenol (CP) showed the highest cytotoxicity (EC 50 : 18-65 mM). Aromatase inhibition was closely related to the hydrophobicity of APs. HP significantly induced the generation of reactive oxygen species (ROS) (43-fold), inhibited placental aromatase activity (IC 50 : 41 mM), and induced a general dose-dependent depletion of polyunsaturated lipids (10-20 mM), which were attributed to high levels of oxidative stress. In contrast, 2,4,6-tritert-butylphenol (TTBP) significantly induced the intracellular accumulation of triacylglycerides (TGs), whereas DP increased the synthesis of phosphatidylcholines (PCs) and TGs at the expense of diacylglycerides (DGs). Overall, this study evidences the different modes of action of alkylphenols in human placental JEG-3 cells, describes differential lipidomic fingerprints, and highlights DP, HP, CP, and TTBP as the ones that caused the most harmful effects.

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“…Blood BPA level in pregnant women was detected with geometric mean of 5.90 μg l −1 (2.58 × 10 −8 m ) (Padmanabhan et al, ). NP levels in blood, placenta and breast milk (Huang et al, ) were higher than that in urine. Analysis of tissue samples collected from 11 patients during autopsy in hospital indicated that BPA was detected in almost all tissues, with the highest level found in adipose tissue at 3.78 μg kg −1 (~1.52 × 10 −8 m ) (Geens et al, ); NP level in adipose tissue was 0.025 μg kg −1 (~1.04 × 10 −10 m ) (Geens et al, ).…”

Section: Introductionmentioning

confidence: 99%

Estrogenic chemicals at body burden levels attenuate energy metabolism in 3T3‐L1 adipocytes

Tsou

Yeh

Hsu

et al. 2017

J of Applied Toxicology

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The study aimed to examine effects of environmental estrogens at body burden levels on energy metabolism in fat cells. Acclimation of T47D-KBluc cells in estrogen-deprived medium was established for high performance of estrogen-responsive luciferase reporter assay. With the assay, relative estrogenic potency of four selected estrogen receptor (ER) agonists, i.e. diethylstilbestrol, β-estradiol, 4-nonylphenol and bisphenol A, were determined. Immunoblot analysis revealed that the ER agonists at both EC and EC caused rapid and transient phosphorylation of extracellular signal-regulated kinases (ERK) in an ER-dependent manner. 3T3-L1 adipocytes treated with the ER agonists at EC for 24 hours exhibited significant downregulation in mitochondrial respiration and glycolytic function. Importantly, EC values of 4-nonylphenol (6.0 × 10 m) and bisphenol A (1.0 × 10 m) are in the range of human body burdens. The finding that estrogenic chemicals at body burden levels cause significant impact on fat cell energy metabolism raises an important public health issue that deserves more attention.

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Nonylphenol in pregnant women and their matching fetuses: Placental transfer and potential risks of infants

Cited by 60 publications

References 49 publications

Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children

Attention Deficit/Hyperactivity Disorder and Urinary Nonylphenol Levels: A Case-Control Study in Taiwanese Children

Differential Toxicity of Alkylphenols in JEG-3 Human Placental Cells: Alteration of P450 Aromatase and Cell Lipid Composition

Estrogenic chemicals at body burden levels attenuate energy metabolism in 3T3‐L1 adipocytes

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