Nonulcer dyspepsia and Helicobacter pylori eradication in children

Farrell, Stephen W.; Milliken, Irene; Murphy, Jane; Wootton, Stephen A.; McCallion, W. A.

doi:10.1016/j.jpedsurg.2005.06.027

Cited by 14 publications

(10 citation statements)

References 16 publications

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“…[3][4][5][6][7][8] To avoid, induction of secondary resistance in the infecting H. pylori strains, as well as further expensive and risky investigations, eradication treatment should reach at least 90% in per-protocol analysis. However, most parents (and children when old enough to understand) are willing to have a treatment, although there is no conclusive evidence, that eradication of the infection will improve their symptoms of dyspepsia.…”

Section: Introductionmentioning

confidence: 99%

“…However, most parents (and children when old enough to understand) are willing to have a treatment, although there is no conclusive evidence, that eradication of the infection will improve their symptoms of dyspepsia. [3][4][5][6][7][8] To avoid, induction of secondary resistance in the infecting H. pylori strains, as well as further expensive and risky investigations, eradication treatment should reach at least 90% in per-protocol analysis. 9,10 However, this goal is seldom obtained in most currently published trials in children.…”

Section: Introductionmentioning

confidence: 99%

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Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children

et al. 2017

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Adherence to therapy is a very important factor for the outcome and has to be assessed when evaluating the outcome of an H. pylori eradication regimen in order to understand the reasons of treatment failure. As we treated only after evaluation of the resistance of the H. Pylori strains, we were expecting to reach the given objective of 90% successful treatment. Children with adherence to treatment above 90% had a successful outcome of 89,9%, whereas nonadherent had a successful outcome of 36,8%. This is the first time that adherence has been assessed accurately.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children

et al. 2017

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“…In adults, there is evidence from randomized clinical trials and meta-analyses that a proportion of infected patients with dyspepsia, in the absence of esophagitis and of gastro-duodenal erosions/ulcers, are improved after successful H. pylori eradication [35][36][37]. In contrast, trials in children investigating the role of H. pylori in dyspepsia are not conclusive because they are uncontrolled [38][39][40][41][42][43][44][45], of poor quality, or do not include sufficient patients to draw conclusions [46]. No clinical manifestations, and especially not recurrent abdominal pain (RAP), have been shown to be specific to H. pylori infection in children.…”

Section: Digestive Manifestationsmentioning

confidence: 99%

Helicobacter pylori Infection in Pediatric Patients: Update on Diagnosis and Eradication Strategies

et al. 2018

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Helicobacter pylori infection is acquired mainly in childhood and remains an essential cause of peptic ulcer disease and gastric cancer. This article provides commentary on the last ESPGHAN/NASPGHAN guidelines and on publications made after the consensus conference of 2015. The majority of infected children are asymptomatic and pediatric studies do not support a role for H. pylori in functional disorders such as recurrent abdominal pain. The role of H. pylori infection in failure to thrive, children's growth, type I diabetes mellitus (T1DM), and celiac disease remains controversial. The diagnosis of infection should be based on upper-digestive endoscopy with biopsy-based methods. Eradication control after treatment should be based on validated non-invasive tests. Nodular gastritis is the main endoscopic finding of childhood H. pylori infection, but gastroduodenal erosions/ulcers are seen in some children, especially after 10 years of age. When indicated, eradication treatment should be given when good compliance is expected and based on the antimicrobial susceptibility profile.

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“…Moreover, some studies suggest a possible impact of H. pylori-associated dyspepsia on anthropometry, as children with dyspepsia and H. pylori infection are shorter and lighter than children with similar symptoms but no infection [82,83]. Evidence for the importance of H. pylori infection as a factor for dyspepsia in childhood comes from H. pylori eradication resulting in a significant long-term improvement of dyspeptic symptoms [84]. The symptoms of H. pylori-associated paediatric dyspepsia however do not differ from those of non-infected dyspeptic children [85], raising questions about which approach should be adopted in children with dyspepsia, in terms of H. pylori testing.…”

Section: Peptic Ulcer -Related Organic Dyspepsia In Paediatrics a Ramentioning

confidence: 99%

Helicobacter pylori—Associated Dyspepsia in Paediatrics

Roxo-Rosa¹,

Oleastro²,

Lopes³

2013

Dyspepsia - Advances in Understanding and Management

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Nonulcer dyspepsia and Helicobacter pylori eradication in children

Cited by 14 publications

References 16 publications

Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children

Eradication rate of Helicobacter Pylori infection is directly influenced by adherence to therapy in children

Helicobacter pylori Infection in Pediatric Patients: Update on Diagnosis and Eradication Strategies

Helicobacter pylori—Associated Dyspepsia in Paediatrics

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