Nontuberculous Tuberculosis Caused by Mycobacterium Gordonae - Clinical Case Report

Tsankova, Gabriela; Kaludova, Violina; Todorova, Tatina T.; Ermenlieva, Neli; Georgieva, E

doi:10.5272/jimab.2015213.856

Cited by 2 publications

(2 citation statements)

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“…There is currently no effective and definitive treatment for M. gordonae infection. Ethambutol, rifabutin, linezolid, CLR and new quinolones are active in vitro as antibiotics, but in vivo data are still insufficient ( 22 , 56 ). Treatment with RMP, INH, pyrazinamide, and ethambutol was successfully used by Tsankova et al .…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic susceptibility of mycobacteria isolated from ornamental fish

Guz

Puk

2022

Journal of Veterinary Research

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Introduction Nontuberculous mycobacteria (NTM) are increasingly recognised as causative agents of opportunistic infections in humans for which effective treatment is challenging. There is very little information on the prevalence of NTM drug resistance in Poland. This study was aimed to evaluate the susceptibility to antibiotics of NTM, originally isolated from diseased ornamental fish. Material and Methods A total of 99 isolates were studied, 50 of them rapidly growing mycobacteria (RGM) (among which three-quarters were Mycobacterium chelonae, M. peregrinum, and M. fortuitum and the rest M. neoaurum, M. septicum, M. abscessus, M. mucogenicum, M. salmoniphilum, M saopaulense, and M. senegalense). The other 49 were slowly growing mycobacteria (SGM) isolates (among which only one was M. szulgai and the bulk M. marinum and M. gordonae). Minimum inhibitory concentrations for amikacin (AMK), kanamycin (KAN), tobramycin (TOB), doxycycline (DOX), ciprofloxacin (CIP), clarithromycin (CLR), sulfamethoxazole (SMX), isoniazid (INH) and rifampicin (RMP) were determined. Results The majority of the isolates were susceptible to KAN (95.95%: RGM 46.46% and SGM 49.49%), AMK (94.94%: RGM 45.45% and SGM 49.49%), CLR (83.83%: RGM 36.36% and SGM 47.47%), SMX (79.79%: RGM 30.30% and SMG 49.49%), CIP (65.65%: RGM 24.24% and SGM 41.41%), and DOX (55.55%: RGM 9.06% and SGM 46.46%). The majority were resistant to INH (98.98%: RGM 50.50% and SGM 48.48%) and RMP (96.96%: RGM 50.50% and SGM 46.46%). Conclusion The drug sensitivity of NTM varies from species to species. KAN, AMK, CLR and SMX were the most active against RGM isolates, and these same four plus DOX and CIP were the best drugs against SGM isolates.

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Section: Discussionmentioning

confidence: 99%

“…Treatment with RMP, INH, pyrazinamide, and ethambutol was successfully used by Tsankova et al . ( 56 ). In a study by Goswami et al .…”

Section: Discussionmentioning

confidence: 99%