Nontuberculous Mycobacterial Mastoiditis

Stewart, Michael G.; Troendle-Atkins, Jane; Starke, Jeffrey R.; Coker, Newton J.

doi:10.1001/archotol.1995.01890020087016

Cited by 31 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In cases of an NTM infection, the mastoid and the middle ear are often filled with a rubbery granular tissue; however, caseating necrosis was rarely observed [Flint et al, 1999;Franklin et al, 1994;Wu et al, 2011]. Poor wound healing after surgery is not uncommon [Flint et al, 1999;Stewart et al, 1995;van Aarem et al, 1998]. In this series, all of the patients suffered refractory otorrhea, followed by acuteonset diplopia, headache, and otalgia, thus fulfilling the diagnostic criteria of Gradenigo syndrome.…”

Section: Discussionmentioning

confidence: 72%

“…abscessus , M. chelonae ssp. chelonae , M. fortuitum , M. avium , M. avium-intracellulare , and M. kansasii, have been reported in otomastoiditis cases [Flint et al, 1999;Franklin et al, 1994;Lowry et al, 1988;Muller et al, 2006;Stewart et al, 1995;TerKonda et al, 1995;van Aarem et al, 1998;Wu et al, 2011]. Most oto- logical NTM infections result from inoculation due to trauma, surgery, or an injection [van Aarem et al, 1998].…”

Section: Discussionmentioning

confidence: 99%

“…NTM and tuberculous otomastoiditis have similar clinical presentations and imaging findings. The common features of the otoscopic findings include painless and odorless otorrhea, a thickened tympanic membrane, and granulation or a polypoid lesion in the external auditory meatus [Flint et al, 1999;Franklin et al, 1994;Muller et al, 2006;Stewart et al, 1995;van Aarem et al, 1998;Wu et al, 2011]. Patients with an NTM infection may have a normal plain chest film, lack general symptoms (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Cervicofacial lymphadenitis is the most common clinical presentation of an NTM infection [Moerman et al, 1993;Sugimoto et al, 2010;van Aarem A et al, 1998]. Conversely, an NTM infection of the ear is relatively uncommon: NTM-related mastoiditis has been sporadically reported in immunocompetent children [Flint et al, 1999;Stewart et al, 1995;Sugimoto et al, 2010;TerKonda et al, 1995;van Aarem et al, 1998] and is even less common in adults [Franklin et al, 1994;Sugimoto et al, 2010;Wu et al, 2011]. Gradenigo syndrome caused by an NTM infection has never been documented in the literature.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Chen

Wu²,

Yang³

et al. 2014

Audiol Neurotol

View full text Add to dashboard Cite

Gradenigo syndrome is a rare but devastating complication of otitis media that involves the petrous apex. Clinically, it is characterized by the triad of suppurative otitis media, deep facial pain, and abducens palsy. Most of the Gradenigo syndrome cases that have been reported in the literature were caused by pyogenic bacteria. In this report, we describe the clinical courses of 4 adults with Gradenigo syndrome who were encountered consecutively at a tertiary referral hospital between 2008 and 2012. Mycobacterium abscessus was confirmed in all 4 cases by culturing the pathological tissues obtained during surgical debridement. To the best of our knowledge, this is the first report documenting infections of nontuberculous mycobacteria (NTM) in Gradenigo syndrome. An NTM infection must be considered in chronic otomastoiditis complicated by Gradenigo syndrome. The definite treatment of Gradenigo syndrome with an NTM infection requires adequate surgical debridement combined with antibiotic treatment for at least 4-6 months.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Chen

Wu²,

Yang³

et al. 2014

Audiol Neurotol

View full text Add to dashboard Cite

show abstract

“…Surgery is not superior to medical treatment [3,5]. The possibility of an infection with atypical Mycobacteria could not be excluded, but such an infection would be resistant to antituberculous agents [4]. Tuberculosis must be included in the dierential diagnosis of any persistent otitis media and mastoiditis.…”

mentioning

confidence: 99%

Tuberculous mastoiditis in a child

Bitsori

Galanakis

Kokori

et al. 1999

European Journal of Pediatrics

View full text Add to dashboard Cite

Sir: Otitis media and mastoiditis of tuberculous origin are extremely rare in childhood and therefore usually not included in the dierential diagnosis of chronic infections of this area, especially when evidence of lung tuberculosis is absent. A case of tuberculous mastoiditis is presented and diagnostic and treatment aspects are discussed.A 4-year-old girl was transferred from a regional hospital because of fever, right ear discharge, swelling of the mastoid area and associated lymphadenitis starting 2 weeks previously. The diagnosis of mastoiditis had been con®rmed by X-rays. Symptoms had persisted despite vigorous antibacterial treatment. The girl had a history of hypertrophic adenoids and multiple episodes of otitis media with ear discharge starting from infancy. On admission white blood cell count was 14,560/mm 3 , erythrocyte sedimentation rate, 42 mm/h; C-reactive protein, 5.2 mg/dL; immunoglobulin E, 602 IU/mL; chest X-ray, normal. CT revealed in¯ammatory swelling of the middle ear and the mastoid air cells. After the surgical excision of a polyp-like structure from the middle ear, symptoms subsided but a gradual deterioration followed despite the continuation of antibiotics. The biopsy specimen showed granulomatous tissue, with necrosis and Langhans giant cells. At this stage a Mantoux test showed an induration of 35 mm and isoniazid and rifampin were administered orally, each at a dose of 10 mg/kg per day for 12 months. Symptoms resolved and no relapse was observed during a 2-year follow up period.

show abstract

Acute Otomastoiditis and its Complications

Lemmerling

2013

Temporal Bone Imaging

View full text Add to dashboard Cite

Nontuberculous Mycobacterial Mastoiditis

Cited by 31 publications

References 18 publications

Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Gradenigo Syndrome Caused by Nontuberculous Mycobacteria

Tuberculous mastoiditis in a child

Acute Otomastoiditis and its Complications

Contact Info

Product

Resources

About