Nontuberculous Mycobacterial Lung Disease in a Patient with COPD and Bronchiectasis, with Radiological Signs of Lung Tumor

Wyrostkiewicz, Dorota; Szturmowicz, Monika; Bartoszuk, Iwona; Siemion-Szcześniak, Izabela; Jakubowska, Lilia; Augustynowicz–Kopeć, Ewa; Kuś, Jan

doi:10.5603/arm.2018.0005

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Patients with a history of lung disease such as COPD have an increased risk of MAC colonization [ 2 ]. In patients with COPD, the risk of contracting a mycobacterial infection is 15 times higher than that of the general population [ 24 ]. One of the main causes of COPD is smoking.…”

Section: Resultsmentioning

confidence: 99%

“…In a case study conducted in Poland by Wyrostkiewicz et al, a 63-year-old male with a history of smoking and COPD was studied after worsening symptoms and MAC infection [ 24 ]. The patient’s X-rays showed chronic bronchitis and bronchiectasis with thickening in the lower lung lobes.…”

Section: Resultsmentioning

confidence: 99%

“…After a 4-week culture, the patient was diagnosed with M. avium infection. The study concluded with the increased susceptibility to MAC infections in patients with COPD [ 24 ]. Due to the increased risk of opportunistic infections in patients with COPD and the commonality of MAC, it is important to consider diagnostic testing early to start the proper treatment.…”

Section: Resultsmentioning

confidence: 99%

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Exploring Potential COPD Immunosuppression Pathways Causing Increased Susceptibility for MAC Infections among COPD Patients

Munjal

Gao

et al. 2021

Clinics and Practice

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Although there has been a drastic decline in the cases of Tuberculosis in the United States, the prevalence of infections caused by Mycobacterium avium Complex (MAC) has steadily increased in the past decades. Mycobacterium avium (M. avium) is one of the most abundant microorganisms in the MAC species. The mycobacterium genus is divided into two major groups: tuberculosis causing mycobacteria and non-tuberculous mycobacteria. MAC is most prominent among the non-tuberculous mycobacteria. MAC is an opportunistic pathogen that is present in soil, water, and droplets in the air. MAC infections can result in respiratory disease and can disseminate in affected patients. MAC infections are especially prevalent in patients with preexisting respiratory conditions such as Chronic Obstructive Pulmonary Disease (COPD). COPD is one of the most common lung conditions in the world with the primary cause being smoking in developed countries. COPD involves chronic inflammation of lung tissue resulting in increased susceptibility to infection. There is a lack of research regarding the pathophysiology that leads COPD patients to be susceptible to MAC infection. Our review paper therefore aims to investigate how the pathogenicity of MAC bacteria and immune decline seen in COPD patients leads to a greater susceptibility to MAC infection among COPD patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Exploring Potential COPD Immunosuppression Pathways Causing Increased Susceptibility for MAC Infections among COPD Patients

Munjal

Gao

et al. 2021

Clinics and Practice

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“…In countries with a high burden of tuberculosis, the isolation rate of NTM has significantly increased in recent years [ 20 – 22 ]. Although the exact impact of NTM pulmonary disease on chronic lung disease remains unclear, patients with chronic obstructive pulmonary disease were found to have a greater risk for worsening situation and high mortality if they were NTM-positive [ 23 , 24 ]. Patients with bronchiectasis accompanied with a positive result for the Mycobacterium avium complex (MAC) have a higher risk for death [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of patients with bronchiectasis with nontuberculous mycobacterial disease in Mainland China: a single center cross-sectional study

Yin

Wang

et al. 2021

BMC Infect Dis

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Background The diagnosis and treatment of patients with bronchiectasis and nontuberculous mycobacterium (NTM) pulmonary disease are challenging issues and the treatment is also prolonged and depends on the species. There is limited information on patients with bronchiectasis and NTM pulmonary disease in Mainland China. Methods This cross-sectional study was conducted at the China–Japan Friendship Hospital, Beijing, China. Those adult patients who met the diagnostic criteria for bronchiectasis and obtained a culture result of mycobacteria from lower respiratory tract specimens or lung tissue were included in this study. A logistic regression model was used to identify the related factors in patients with NTM pulmonary disease. Results A total of 202 patients with bronchiectasis from 19 cities, 155 without and 47 (23.3%) with NTM pulmonary disease, were included. In all the 47 patients with NTM pulmonary disease, Mycobacterium avium complex was the most common species (66.0%), and 72.3% of them were initiated on standard anti-NTM treatment within 3 months after the diagnosis of NTM pulmonary disease. A larger proportion of patients with NTM pulmonary disease had acute exacerbations of ≥ 3 times within 1 year and were diagnosed bronchiectasis ≥ 50 years among patients with NTM pulmonary disease. The HRCT chest images revealed higher proportions of nodular shadow (100% vs. 35.3%), tree-in-bud sign (97.9% vs. 29.0%), cavities (29.8% vs. 5.8%), and airway dilation of the right middle lobe or the left lingular lobe (63.8% vs. 23.9%) in patients with NTM pulmonary disease than in those without NTM pulmonary disease (all P values = 0.001). The multivariable logistic regression model indicated that three and more abnormal features (OR 33.8; 95% CI 11.1–102.8) and main lesions of bronchial expansion in the middle or lingual lobe (OR 6.4; 95% CI 2.4–16.6) in HRCT chest images were independently associated with NTM pulmonary disease (P values = 0.001). Conclusion In a single center of Mainland China, > 23% of patients with bronchiectasis had NTM pulmonary disease, and most patients were started on standard treatment within 3 months after the diagnosis of NTM pulmonary disease. These findings suggest that patients with bronchiectasis should be thoroughly examined for the presence of NTM pulmonary disease. Trial registration NCT03594032.

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“…The most predominant for NTM disease are hematologic malignancies and lung cancer, with Mycobacterium avium as the most common causative pathogen [ 3 , 4 ]. On the other hand, radiologic features of NTM lung disease may mimic malignancy [ 5 , 6 ]. A coexistence of NTM infection and cancer in the same lesion has also been reported [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Mycobacterium szulgai Lung Disease or Breast Cancer Relapse—Case Report

Kempisty¹,

Augustynowicz–Kopeć²,

Opoka³

et al. 2020

Antibiotics

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Cancers are one of the risk factors of non-tuberculous mycobacterial (NTM) lung disease. The majority of data in this group of patients concern infections caused by Mycobacterium avium—the most prevalent NTM species worldwide. In contrast, limited information can be found regarding the uncommon NTM such as Mycobacterium szulgai. We present the case of M. szulgai lung disease in a patient with a history of breast cancer. Coexistence of NTM lung disease and breast cancer lung metastasis as well as primary lung cancer was suspected. Finally, neoplastic disease was ruled out based on negative results of endobronchial biopsy and negative tumor markers for lung and breast cancer. M. szulgai lung disease was successfully treated with rifampicin, ethambutol and clarithromycin.

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Nontuberculous Mycobacterial Lung Disease in a Patient with COPD and Bronchiectasis, with Radiological Signs of Lung Tumor

Cited by 6 publications

References 18 publications

Exploring Potential COPD Immunosuppression Pathways Causing Increased Susceptibility for MAC Infections among COPD Patients

Exploring Potential COPD Immunosuppression Pathways Causing Increased Susceptibility for MAC Infections among COPD Patients

Clinical characteristics of patients with bronchiectasis with nontuberculous mycobacterial disease in Mainland China: a single center cross-sectional study

Mycobacterium szulgai Lung Disease or Breast Cancer Relapse—Case Report

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