Nontuberculous Mycobacterial Infections in Pediatric Acute Leukemia

Suryanarayan, Kaveri; Eskenazi, Allen E.

doi:10.1097/00043426-200210000-00013

Cited by 20 publications

(13 citation statements)

References 11 publications

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“…They drew the conclusion that no therapy of indolent colonization is necessary. The outcome of our case and the experience of Suryanarayan et al [21] and Levendoglu-Tugal et al [20] also support this view.…”

Section: Discussionsupporting

confidence: 83%

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Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma

Tschiedel

Grasemann

Ratjen

2006

Journal of Cystic Fibrosis

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A 13-year-old patient with cystic fibrosis was diagnosed with anaplastic large cell lymphoma. At the same time colonization with Mycobacterium chelonae was detected in sputum cultures. Despite massive immunosuppression, the patient did not show evidence of mycobacterial invasive disease. Colonisation persisted for 18 months after discontinuation of chemotherapy and was not detected in the 6 years thereafter. This case highlights the dilemma of differentiating between colonisation and infection if mycobacteria are found in CF sputum samples.

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Section: Discussionsupporting

confidence: 83%

“…There are no reports related to the NTM infection in paediatric patients with lymphoma, but individual cases have been published in patients with leukaemia [20,21]. In contrast to our case, all those patients were treated with antimicrobial therapy directed against mycobacteria.…”

Section: Discussionmentioning

confidence: 55%

Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma

Tschiedel

Grasemann

Ratjen

2006

Journal of Cystic Fibrosis

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“…The monocytopenia and impaired monocyte function seen in this disorder may explain this association [123]. There are several reports of NTM disease associated with other acute and chronic leukaemias [124,[128][129][130][131].…”

Section: Malignancymentioning

confidence: 99%

Susceptibility to nontuberculous mycobacterial lung disease

Sexton¹,

Harrison²

2008

European Respiratory Journal

142

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The nontuberculous mycobacteria (NTM) exhibit heterogeneous pathogenicity in humans. Articles on known and potential human factors capable of producing susceptibility to NTM lung disease (NTMLD) were identified by a systematic search of the medical literature, and are reviewed in the present study.Patients with pre-existing structural lung disease are known to be at risk of NTMLD. Other susceptible groups have become recognised since the 1980s, in particular middle-aged nonsmokers without previous lung disease (a group including those with Lady Windermere syndrome) and patients with genetically determined defects of cell-mediated immunity, including abnormalities of the interleukin-12/interferon-c axis, certain human leukocyte antigen alleles, cystic fibrosis transmembrane conductance regulator mutations, and polymorphisms of solute carrier 11A1 (or natural resistance-associated macrophage protein 1) and the vitamin D receptor.Information is also accruing about acquired systemic causes of susceptibility to NTMLD, including inhibitory antibodies directed against interferon-c, post-menopausal waning of endogenous oestrogen levels, coeliac disease and exposure to use of dietary phyto-oestrogens. It is not known whether immunosuppressive factors, such as oral corticosteroid treatment, chronic renal failure, diabetes mellitus and other known risk factors for pulmonary tuberculosis, are also risk factors for the development of NTMLD. Caution is appropriate in managing such patients.

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“…Nontuberculous mycobacteria are uncommon causes of catheter-associated infections that are becoming more frequently recognized (8,11,14). Several reports have described infections in neutropenic and nonneutropenic cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Novel Rapidly Growing Mycobacterium Species Associated with Sepsis

Hong¹,

Butler

Hollis³

et al. 2003

J Clin Microbiol

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A rapidly growing mycobacterium was isolated five times from blood cultures from a 6-year-old female patient with relapsed pre-B-cell acute lymphocytic leukemia. All five isolates had identical nucleotide sequences for the first 500 bp of the 16S rRNA gene, indicative of a single species. High-performance liquid chromatography analysis of mycolic acids indicated that the species was similar to Mycobacterium smegmatis. Sequence analysis of the 16S rRNA gene (1,455 bp) for one isolate demonstrated that the species was closely related to Mycobacterium diernhoferi. Based on the phenotypic features and phylogenetic analysis, it was concluded that the isolates represented a novel rapidly growing Mycobacterium species. The name "Mycobacterium hackensackense" is proposed for this unique strain, 147-0552 T , which was deposited in the American Type Culture Collection as ATCC BAA-823 T .By definition, rapidly growing mycobacteria (RGM) demonstrate visible growth on culture media within 7 days. The species of RGM capable of causing human infections are primarily of the Mycobacterium fortuitum group, the M. chelonae/M. abscessus group, and the M. smegmatis group. Some of the diseases caused by RGM include posttraumatic and postsurgical wound infections, bone and joint infections, catheter-related infections, postinjection abscesses, disseminated cutaneous disease, pulmonary disease, central nervous system disease, and cervical lymphadenitis. The most common mycobacterial pathogen associated with catheter infections is M. fortuitum. However, M. chelonae, M. abscessus, M. immunogenum, the M. smegmatis group, and M. mucogenicum have also been associated with catheter-related infections (4).Traditionally, clinical laboratory identification of RGM involved selected biochemical tests, pigmentation, and colony morphology. However, it has been shown that these methods lack sensitivity and can be influenced by phenotypic variability (13). The development of high-performance liquid chromatography (HPLC) analysis of cell wall-bound, species-specific mycolic acids (5) and nucleic acid-based technologies provided fast and accurate identification tests for Mycobacterium species. Additionally, 16S rRNA gene sequence analysis has been used to describe the phylogenetic relationships among mycobacterial species (12). In this report, a novel rapidly growing Mycobacterium species involved in a catheter-related mycobacteriosis of a young female patient with relapsed pre-B-cell acute lymphocytic leukemia is described. MATERIALS AND METHODSCase report. In May 2002, a 6-year-old female with relapsed pre-B-cell acute lymphocytic leukemia and a history of multiple previous infections was admitted at Hackensack University Medical Center for evaluation with a fever of 39.5°C. She was initially diagnosed in November 1997 and received chemotherapy (Pediatric Oncology Group [POG] protocol 9606), which was finished in July 2000. Chemotherapy (POG protocol 9411) was resumed for a bone marrow relapse, diagnosed in June 2001. Since then, the patient has had ...

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Nontuberculous Mycobacterial Infections in Pediatric Acute Leukemia

Cited by 20 publications

References 11 publications

Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma

Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma

Susceptibility to nontuberculous mycobacterial lung disease

Characterization of a Novel Rapidly Growing Mycobacterium Species Associated with Sepsis

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