Nontuberculous Mycobacteria in Portugal: Trends from the last decade

Santos, Andrea; Carneiro, Sofia; Silva, A.; Gomes, João Paulo; Macedo, Rita

doi:10.1016/j.pulmoe.2022.01.011

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…For this study, this might have to some extent affected the levels of reliability and validity of data generated hence the inferential statistical measures. Furthermore, the lack of previous studies done on the topic has limited the level of validity of the findings [41]. However, our study shed light on the awareness of NTM among HCWs that warrant further studies and interventions.…”

Section: Limitationsmentioning

confidence: 72%

Non-tuberculous mycobacterial pulmonary disease: Awareness survey of front-desk healthcare workers in Northern Tanzania

Maya

Komba²,

Mensah³

et al. 2023

PLOS Glob Public Health

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Over the past decade, there have been increasing reports of non-tuberculous mycobacteria (NTM) species being implicated in tuberculosis (TB) treatment failure or misdiagnosed as TB. Inadequate awareness of NTM pulmonary disease among healthcare workers (HCWs) may contribute to a low index of suspicion for patients presenting to their hospitals. In this study, we assessed the awareness of NTM pulmonary disease (NTM-PD) among front desk HCWs in Northern Tanzania. A cross-sectional descriptive survey was carried out among front desk HCWs in four administrative regions of Northern Tanzania. A standardized questionnaire was administered to consented participants from four clusters; clinicians, laboratory scientists, nurses, and pharmacists serving TB patients from Regional and District Health Facilities. Each participant was asked a set of questions, scored and the total score for each participant was determined. An awareness score was used to measure the level of awareness. The average score for all participants was estimated including the 95% confidence interval (CI). The overall awareness score was 24.1%, 95% CI 22.0–26.2%. History of training, experience in TB care, level of health facilities, age group, and setting were found to be statistically associated with the level of awareness of study participants. More than two-thirds (67%) of participants believe that pulmonary NTM and TB are clinically similar and 60% are not aware that AFB Microscopy cannot distinguish between the two. Only 13% of participants could mention at least one risk factor for NTM pulmonary disease. The level of awareness of NTM pulmonary disease was poor among HCWs in the surveyed TB clinics. National TB Programs are advised to include a topic on NTM in various on-job TB training packages for HCWs.

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Section: Limitationsmentioning

confidence: 72%

Non-tuberculous mycobacterial pulmonary disease: Awareness survey of front-desk healthcare workers in Northern Tanzania

Maya

Komba²,

Mensah³

et al. 2023

PLOS Glob Public Health

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“…Nontuberculous mycobacteria (NTM) are a collective group of more than 190 species and subspecies other than Mycobacterium leprae or Mycobacterium tuberculosis complex (MTBC) [1] . Globally, NTM infections are steadily increasing due to increased immune suppression in patients and aging populations with increased diagnosis being driven by improved diagnostic techniques and heightened awareness of NTM infection [2] .…”

Section: Introductionmentioning

confidence: 99%

Incorporating direct molecular diagnostics in management algorithms for nontuberculous mycobacteria: Is it high time?

Opperman,

Singh,

Goosen

et al. 2024

IJID Regions

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“… 1 , 2 Despite the fact that NTM as a group is comprised of numerous species, human NTM diseases appear to be caused mainly by only two NTM species, Mycobacterium avium complex and Mycobacterium abscessus complex (MABC). 3 , 4 MABCs are rapidly growing mycobacterial organisms that are frequently responsible for pulmonary infections, skin and soft tissue infections, and nosocomial infections. 5 Three subspecies of MABCs are known: M. abscessus subsp.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex

Gao

Yao

Shang

et al. 2023

IDR

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Purpose Unsatisfactory efficacies of currently recommended anti- Mycobacterium abscessus complex (MABC) treatment regimens have led to development of novel drugs to combat MABC infections. In this study, we evaluated in vitro antimicrobial activities of bedaquiline (BDQ) and four oxazolidinones against MABC isolates. Methods The resazurin microplate assay was performed to determine minimum inhibitory concentrations (MICs) of BDQ and four oxazolidinones, including tedizolid (TZD), sutezolid (SZD), delpazolid (DZD), and linezolid (LZD), against 65 MABC isolates. A checkerboard method was used to investigate efficacies of various antimicrobial drug combinations. Results BDQ MICs for MABC isolates ranged from <0.031 to 1 µg/mL, while MIC 50 and MIC 90 values were 0.125 µg/mL and 0.25 µg/mL, respectively. TZD MIC 50 and MIC 90 values for MABC isolates were 1 µg/mL and 4 µg/mL, respectively, which were fourfold lower than corresponding LZD values (P < 0.001). DZD MIC 90 values for MABC isolates was 8 µg/mL, which were 0.5-fold lower than corresponding LZD values (P < 0.01). MICs of BDQ, SZD, and LZD for M. abscessus subspecies massiliense isolates were significantly lower than corresponding MICs for M. abscessus subspecies abscessus isolates (P < 0.05). Notably, use of oxazolidinones (DZD, SZD, LZD, or TZD) with BDQ against MABC isolates led to reduction of the oxazolidinone median MIC range from 4 to 0.125 µg/mL to 1–0.031 µg/mL. Conclusion These results demonstrated excellent BDQ inhibitory activity against MABC isolates. TZD exhibited stronger antimicrobial efficacy against MABC isolates as compared to efficacies of DZD, SZD, and LZD. Importantly, MICs of oxazolidinones were markedly decreased when they were combined with BDQ, thus suggesting that combinations of BDQ and oxazolidinones may be effective treatments for MABC infections.

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Nontuberculous Mycobacteria in Portugal: Trends from the last decade

Cited by 8 publications

References 26 publications

Non-tuberculous mycobacterial pulmonary disease: Awareness survey of front-desk healthcare workers in Northern Tanzania

Non-tuberculous mycobacterial pulmonary disease: Awareness survey of front-desk healthcare workers in Northern Tanzania

Incorporating direct molecular diagnostics in management algorithms for nontuberculous mycobacteria: Is it high time?

Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex

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