Nontuberculous Mycobacteria in Patients with Cystic Fibrosis

Oliver, Antonio; Máiz, Luís; Cantón, Rafael; Escobar, Héctor; Baquero, Fernando; Gómez-Mampaso, E

doi:10.1086/319987

Cited by 83 publications

(40 citation statements)

References 13 publications

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“…The potential for patients with CF to have "indolent infection" by NTM, including M. abscessus, has previously been described in case series but is not well defined or universally accepted (8,12,14,31,32). Over the period of analysis, spanning ORIGINAL RESEARCH 1 year before and 3 years after the initial positive culture, we were unable to demonstrate a difference in FEV 1 decline between subjects with transient or persistent infection.…”

Section: Discussionmentioning

confidence: 67%

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

et al. 2014

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Rationale: Little is known about outcomes of infection with nontuberculous mycobacteria (NTM) in cystic fibrosis (CF) or about the significance of a positive NTM culture. Determining which patients are at risk for active NTM disease is clinically valuable.Objectives: To examine the clinical course of subjects with CF with an initial positive NTM culture and identify characteristics associated with active NTM disease.Methods: We performed a retrospective study of pediatric and adult subjects with CF with at least one positive NTM culture at the Colorado CF Center from 2000 to 2010.Measurements and Main Results: Mycobacterium avium complex was the first identified NTM in the majority of subjects (73%). The frequency of growing a second NTM species was 26% at 5 years. Clinical characteristics and distribution of NTM species between pediatric and adult subjects were similar except for differences in baseline FEV 1 (89% vs. 71%; P , 0.001) and coinfection with Pseudomonas aeruginosa (33% vs. 55%; P = 0.04). Over 60% of subjects had transient or persistent infection but not active NTM disease. Subjects who developed active NTM disease were distinguished from those with transient or persistent infection, respectively, by FEV 1 at the time of first positive NTM culture (72% vs. 84 or 86%; P = 0.02) and FEV 1 decline in the prior year (25.8%/yr vs. 20.7%/yr [P = 0.009] or 20.4%/yr [P = 0.001]). Conclusions:The majority of patients with CF with a first positive NTM culture do not progress to active disease. Lower lung function and accelerated lung function decline appear to be indicators of the significance of an initial positive NTM culture.

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Section: Discussionmentioning

confidence: 67%

Clinical Significance of a First Positive Nontuberculous Mycobacteria Culture in Cystic Fibrosis

et al. 2014

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“…Serologic diagnosis, such as determining the presence of IgG immunoglobulin against antigen A 60 (Oliver et al, 2001), has been discarded due to its low sensitivity and specificity (Pottumarthy et al, 2000). Tuberculin skin testing may be positive in patients infected with NTM, since M. tuberculosis shares antigens with various species, but generally the induration induced is less than 10 mm in diameter (Field & Cowie, 2006 There is controversy over the systematic use of susceptibility testing of NTM, since there is no clear correlation to the clinical therapeutic response.…”

Section: Microbiological Diagnosismentioning

confidence: 99%

Infection by Non Tuberculous Mycobacteria in Cystic Fibrosis

Santos¹,

Gil-Brusola²,

Morales³

2012

Cystic Fibrosis - Renewed Hopes Through Research

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“…Nontuberculous mycobacteria infections with neurologic or systemic localizations exhibit a low titre of IgG (Oliver et al, 2001). In addition the presence of corresponding antibodies in HIV patients suggests colonization (usually involving the digestive tract) rather than infection (Maes 1991).…”

Section: Diagnostic Value Of Immunological Assays In Patients With Nementioning

confidence: 99%