Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis

Bonaiti, Giulia; Pesci, Alberto; Marruchella, Almerico; Lapadula, Giuseppe; Gori, Andrea; Aliberti, Stefano

doi:10.1155/2015/197950

Cited by 69 publications

(61 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Potential explanations for differences between populations may relate to geographical variations in both the prevalence and causative organisms of NTM infection or genetic predisposition [22] . NTM are also notoriously difficult to culture, especially in the presence of other colonising organisms, possibly accounting for a degree of variability [23] .…”

Section: Discussionmentioning

confidence: 99%

Patterns of Disease in Patients with Middle-Lobe Predominant Bronchiectasis

McDonnell

Ahmed²,

Das³

et al. 2017

Respiration

View full text Add to dashboard Cite

Background: Middle-lobe predominant bronchiectasis affecting the right middle-lobe and/or lingula (RMLP) is classically described in asthenic, elderly females with skeletal abnormalities or associated nontuberculous mycobacterial (NTM) infection. Objectives: We aimed to evaluate the frequency and clinical characteristics of patients with an RMLP phenotype in a cohort of newly diagnosed bronchiectasis patients and determine associations with disease severity. Methods: A retrospective observational cross-sectional cohort study of consecutive bronchiectasis patients in our institution was performed. Data were collected on baseline variables, microbiology status, lung function, and radiology according to the modified Bhalla score. Disease severity was assessed using bronchiectasis severity index (BSI) and FACED severity scores. Results: Of 81 patients (mean age [SD] 62.6 [12.4], females 55 [67.9%], BMI 26.9 [5.7%]), 20 (24.7%) had RMLP disease. These patients were significantly younger, female, and with lower BMIs than patients with the classical bronchiectasis phenotype (p = 0.03, 0.01, and p <0.01, respectively). Fewer symptoms of cough and daily sputum (p = 0.01 and <0.01), prior exacerbation frequency (p = 0.03), and higher baseline forced expiratory volume (p = 0.04) were noted. A higher incidence of NTM at diagnosis was demonstrated (p = 0.01). BSI and FACED severity scores in RMLP patients were significantly lower than their counterparts (both p < 0.001). Conclusions: The RMLP phenotype is associated with younger patients than classically described in the literature. An increased rate of NTM infection in this phenotype was noted, particularly in females, but much lower than previously described. Lung function and disease severity scores in this patient group are relatively normal, suggesting a milder phenotype in patients with this form of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Patterns of Disease in Patients with Middle-Lobe Predominant Bronchiectasis

McDonnell

Ahmed²,

Das³

et al. 2017

Respiration

View full text Add to dashboard Cite

show abstract

“…Few data have been published regarding the prevalence of fungal colonisation and it is now possible to perform sequencing of the fungal "mycobiome" in a similar way to that described above for bacteria [38][39][40]. The prevalence of nontuberculous mycobacteria (NTM) in Europe is <10%, although there seems to be a broad geographic variation [41]. The role of NTM, between innocent colonisers or those causing chronic infection, and the predisposing factors to this need to be differentiated.…”

Section: Consensus Statementmentioning

confidence: 99%

Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration

et al. 2016

Self Cite

View full text Add to dashboard Cite

Bronchiectasis is a disease of renewed interest in light of an increase in prevalence and increasing burden on international healthcare systems. There are no licensed therapies, and large gaps in knowledge in terms of epidemiology, pathophysiology and therapy. The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration, funded by ERS to promote high-quality research in bronchiectasis. The objective of this consensus statement was to define research priorities in bronchiectasis. From 2014 to 2015, EMBARC used a modified Delphi process among European bronchiectasis experts to reach a consensus on 55 key research priorities in this field. During the same period, the European Lung Foundation collected 711 questionnaires from adult patients with bronchiectasis and their carers from 22 European countries reporting important research priorities from their perspective. This consensus statement reports recommendations for bronchiectasis research after integrating both physicians and patients priorities, as well as those uniquely identified by the two groups. Priorities identified in this consensus statement provide the clearest possible roadmap towards improving our understanding of the disease and the quality of care for patients with bronchiectasis. @ERSpublications EMBARC consensus statement identifies research priorities in bronchiectasis as determined by physicians and patients

show abstract

“…NTM can cause bronchiectasis by destroying the bronchial anatomy, and bronchiectasis can predispose patients to NTM colonization/disease due to impaired host local defenses [101,102]. NTM lung disease in bronchiectasis can also be complicated by coinfection with other bacteria, especially…”

Section: Host Factorsmentioning

confidence: 99%

Nontuberculous mycobacterial lung disease: ecology, microbiology, pathogenesis, and antibiotic resistance mechanisms

Kim¹,

Han²,

Kim

et al. 2017

Precis Future Med

View full text Add to dashboard Cite

The incidence and prevalence of lung disease caused by nontuberculous mycobacteria (NTM) are increasing worldwide. Environmental sources of NTM include water, soil, and dust, and the acquisition of NTM infection depends on sufficient environmental exposure, host susceptibility factors such as immunocompromised status or cystic fibrosis, and mycobacterial virulence factors. The development of molecular methods has allowed the characterization of new species and the identification of NTM to the precise species and subspecies levels. Mycobacterium avium complex, M. abscessus complex, and M. kansasii are the most frequently identified organisms causing lung disease. Susceptibility to disease is incompletely understood, and thus, it is unclear what preventative measures may be effective. Additionally, NTM have natural and acquired resistance mechanisms to several antibiotics. Better understanding of the ecology, pathogenesis, and mycobacterial genetics and antibiotic resistance mechanisms is essential for preventing NTM infections and developing new regimens for effective treatment.

show abstract

Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis

Cited by 69 publications

References 59 publications

Patterns of Disease in Patients with Middle-Lobe Predominant Bronchiectasis

Patterns of Disease in Patients with Middle-Lobe Predominant Bronchiectasis

Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical Research Collaboration

Nontuberculous mycobacterial lung disease: ecology, microbiology, pathogenesis, and antibiotic resistance mechanisms

Contact Info

Product

Resources

About