Nontuberculous mycobacteria in cystic fibrosis patients on the Island of Gran Canaria. A population study

Campos-Herrero, Ma Isolina; Chamizo, Francisco; Caminero, José A.; Gilarranz, Raúl; Cabrera, Gonzalo; Cuyás, José M.

doi:10.1016/j.jiac.2016.04.010

Cited by 11 publications

(10 citation statements)

References 24 publications

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“…Our analysis reported a risk of NTM acquisition associated with S. aureus , S. maltophilia , and A. fumigatus colonization. This present analysis corroborates previously reported associations for S. aureus , 8,13,18,40 S. maltophilia , 6,9,10,19 and A. fumigatus 3,6,9,13,20,41,42 . These results may allude to the fact that patients with these chronic colonizations had a long history of CF‐related infections and more extensive lung damage predisposing them to NTM.…”

Section: Discussionsupporting

confidence: 92%

“…This present analysis corroborates previously reported associations for S. aureus, 8,13,18,40 S. maltophilia, 6,9,10,19 and A. fumigatus. 3,6,9,13,20,41,42 These results may allude to the fact that patients with these chronic colonizations had a long history of CF-related infections and more extensive lung damage pre- been shown to modestly improve lung function and to decrease pulmonary exacerbations, 45,46 but this use of long-term antibiotics raises several concerns. Azithromycin use has been shown to block autophagy, suggesting that it has the potential to predispose patients with CF to mycobacterial infection.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for nontuberculous mycobacterial isolation in patients with cystic fibrosis: A meta‐analysis

Reynaud

Bricca

Cavalli

et al. 2020

Pediatric Pulmonology

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Background To better understand the mechanisms of infection with nontuberculous mycobacteria (NTM) in patients with cystic fibrosis (CF), we explore different risk factors associated with NTM positivity in a meta‐analysis. Methods Studies published before 31 July 2019 were selected from MEDLINE. Combined odds ratios (ORs) were calculated by pooling the ORs of each study. The weighted mean difference (WMD) was used for continuous numerical measurements. Summary data were pooled using fixed‐ or random‐effects models according to the presence of heterogeneity (P < .1 or I2 > 50%). Results Nineteen studies with a total of 23 418 patients, of whom 1421 (6%) were diagnosed as NTM positive, were included. Older age was significantly associated with NTM positivity (WMD = 2.12, 95% confidence interval [CI]: 1.11‐3.13; P < .01, fixed‐effects model). The OR for Staphylococcus aureus colonization was 1.66 (95% CI: 1.21‐2.26; P = .001) in 11 studies (8091 patients), the OR for Aspergillus fumigatus colonization was 3.59 (95% CI: 3.05‐4.23; P < .001) in 11 studies (20 480 patients), and the OR for Stenotrophomonas maltophilia colonization was 3.41 (95% CI: 2.66‐4.39; P < .01) in seven studies (14 935 patients). Oral corticosteroids were significantly associated with NTM positivity (OR = 1.98, 95% CI: 1.24‐3.16; P < .01, 6 studies, 1936 patients). No other factor showed a significant association. Conclusion Older age, S. aureus, S. maltophilia, and A. fumigatus chronic colonization, and oral corticosteroids were significantly associated with an increased risk of NTM positivity. CF patients with more severe conditions should be closely monitored for NTM.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Risk factors for nontuberculous mycobacterial isolation in patients with cystic fibrosis: A meta‐analysis

Reynaud

Bricca

Cavalli

et al. 2020

Pediatric Pulmonology

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“…11 The reported prevalence of NTM in the CF population varies widely, ranging from 4.2 to 40.9%. 10,11,[18][19][20][21] These studies vary methodologically in multiple aspects, including design (prospective vs. retrospective), geography, clinical practice, and organism recovered, which may account for some differences. For example, higher rates in urban areas may be a reflection of greater access to care, whereas increased prevalence in certain geographical locations may reflect a common risk factor.…”

Section: Epidemiologymentioning

confidence: 99%

“…The CF airways have a complex microbiome, but no organism has been definitively demonstrated to be protective against or facilitate infection with NTM; however, there is an association with Aspergillus, in particular there is an association with allergic bronchopulmonary aspergillosis (ABPA). 1,16,18,21,24,[26][27][28][29][30][31][32][33] Analysis of European registry data demonstrated that ABPA was associated with a 2.36 times chance of having a respiratory culture grow an NTM organism. 33 It has been hypothesized that a change in the immune system favoring a T-helper (Th)2 CD4þ T cell response, as is seen in ABPA, downregulates cytokines essential for eradication of NTM, thus allowing a favorable environment for the mycobacteria to survive and replicate.…”

Section: Epidemiologymentioning

confidence: 99%

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Nontuberculous Mycobacteria in Cystic Fibrosis

Furukawa

Flume

2018

Semin Respir Crit Care Med

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Nontuberculous mycobacteria (NTM) can cause chronic pulmonary infection in susceptible hosts. Individuals with cystic fibrosis (CF), a multisystem disease predominated by progressive structural lung disease, are particularly vulnerable. Only recently have NTM been recognized for their potential to cause lung deterioration in CF patients. The reported prevalence varies widely from 4 to 40%, significantly more common than in the general population, but this varies because of multiple factors including inconsistent screening practices. complex and complex are the two most common species recovered. Defining NTM pulmonary disease in a CF patient can present challenges as it can be difficult to distinguish from the other potentially pathogenic organisms in the lung microbiome. In general, treatment regimens do not differ from the non-CF population but the clinician should be aware of potential interactions with other CF therapies. Recent population-level genomics has raised serious concern for indirect person-to-person transmission of several dominating NTM clones worldwide, raising awareness for increase prevention strategies when CF patients potentially congregate, such as clinic visits. Lung transplantation is controversial in those with NTM present in sputum culture but the available evidence suggests that this is not an absolute contraindication.

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Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis

Waters

Ratjen

2016

Cochrane Database of Systematic Reviews

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Nontuberculous mycobacteria in cystic fibrosis patients on the Island of Gran Canaria. A population study

Cited by 11 publications

References 24 publications

Risk factors for nontuberculous mycobacterial isolation in patients with cystic fibrosis: A meta‐analysis

Risk factors for nontuberculous mycobacterial isolation in patients with cystic fibrosis: A meta‐analysis

Nontuberculous Mycobacteria in Cystic Fibrosis

Antibiotic treatment for nontuberculous mycobacteria lung infection in people with cystic fibrosis

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