Nontreatment and Aggressive Narcotic Therapy Among Hospitalized Pancreatic Cancer Patients

Brown, Norman K.; Thompson, Donovan J.; Prentice, Ross L.

doi:10.1111/j.1532-5415.1998.tb02717.x

Cited by 6 publications

(3 citation statements)

References 36 publications

(43 reference statements)

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“…nally ill patients [7][8][9][10][11][12][13][14], the results of which are summarized in table 1. In most studies, a significant proportion of terminally ill patients continued to receive antibiotics, which is consistent with the view that physicians may find the administration of these drugs "routine" and less subject to either withdrawal or withholding.…”

Section: Ethical Principlesmentioning

confidence: 99%

Ethical Issues Relating to the Use of Antimicrobial Therapy in Older Adults

Marcus¹,

Clarfield

Moses

2001

CLIN INFECT DIS

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This article aims to review the literature relating to the ethics of antibiotic prescription decisions in older adults and to offer some suggestions as to how one might approach these difficult problems. According to many studies, most patients and their family members wish to receive antibiotics even when they are terminally ill or suffering from advanced dementia. Health care professionals are also frequently reluctant to deny the use of antibiotics in such situations. We suggest that the difficult decisions regarding whether one should withhold treatment can be based on consideration of the ethical principles of autonomy, beneficence, nonmaleficence, and justice. From the public health point of view, one should also take into account the need to avoid the emergence of antimicrobial resistance, keeping in mind the balance between the benefit to the specific patient and the cost to future patients. Infectious diseases consultants should actively participate in these ethical dilemmas.

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Section: Ethical Principlesmentioning

confidence: 99%

Ethical Issues Relating to the Use of Antimicrobial Therapy in Older Adults

Marcus¹,

Clarfield

Moses

2001

CLIN INFECT DIS

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“…17,33,34 Interventions targeting increases in total calorie delivery have only improved a portion of the growth delay. [35][36][37] Similarly, replacement of micronutrients -including iron, vitamin A, and zinc -has had limited success in improving growth, potentially related to poor absorption during ongoing infections. [38][39][40] Thus, the exact causes of growth failure in the setting of enteric diseases may be multifactorial.…”

Section: Malnutrition As An Enteric Diseasementioning

confidence: 99%

“…Enteric infections in early childhood are associated with a decrease in the absorption of macronutrients, 17 a decrease in the absorption of micronutrients, 31,32 and increases in systemic inflammation, and each of these processes may contribute to growth delay 17,33,34 . Interventions targeting increases in total calorie delivery have only improved a portion of the growth delay 35–37 . Similarly, replacement of micronutrients – including iron, vitamin A, and zinc – has had limited success in improving growth, potentially related to poor absorption during ongoing infections 38–40 .…”

Section: Malnutrition As An Enteric Diseasementioning

confidence: 99%

Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

et al. 2012

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Hypotheses regarding the developmental origins of health and disease postulate that developing fetuses–and potentially young children—undergo adaptive epigenetic changes with longstanding effects on metabolism and other processes. Ongoing research explores whether these adaptations occur during early life following malnutrition. In the developing world there remains a high degree of nutritional stunting—linear growth failure due to inadequate calories that may be exacerbated by inflammation from ongoing infections. In areas with poor sanitation children experience vicious cycles of enteric infections and malnutrition, resulting in poor nutrient absorption from intestinal mucosa changes now termed “environmental enteropathy.” Emerging evidence links early childhood diarrhea and/or growth failure with increased CVD risk factors in later life, including dyslipidemia, hypertension and glucose intolerance. The mechanisms for these associations remain poorly understood and may relate to epigenetic responses to poor nutrition, increased inflammation or both. Given increases in CVD in developing areas of the world, associations between childhood malnutrition, early life infections and increased CVD risk factors underscore further reasons to improve nutrition and infection-related outcomes for young children worldwide.

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Bibliometric Analysis and Visualization of Catholic Health Care Research: 1973–2019

2021

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Nontreatment and Aggressive Narcotic Therapy Among Hospitalized Pancreatic Cancer Patients

Abstract: Both nontreatment and aggressive narcotic therapy forms of medical management have been occurring commonly in terminal pancreatic cancer patients in King County, Washington, during the past 3 decades, the latter with greater frequency in recent years.

Cited by 6 publications

References 36 publications

Ethical Issues Relating to the Use of Antimicrobial Therapy in Older Adults

Ethical Issues Relating to the Use of Antimicrobial Therapy in Older Adults

Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

Bibliometric Analysis and Visualization of Catholic Health Care Research: 1973–2019

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