Nontraditional Cardiovascular Biomarkers and Estimation of Cardiovascular Risk in Predialysis Chronic Kidney Disease Patients and Their Correlations With Carotid Intima Media Thickness

Sathi, Satyanand; Mahapatra, Himansu Sekhar; Sunder, S.; Jayaraman, Rajesh; Sharma, Neera; Verma, Himanshu; Venkataramanan, K.; Gupta, Anurag; Kanchi, Prabhu; Daksh, Sunil Kumar; Pursnani, Lalit; Shadab, Faisal; Singh, Manveer

doi:10.5812/numonthly.22112

Cited by 8 publications

(9 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, only the CKD-EPIcr equation showed significant association with insulin. In contrast we found no association between CKD and arterial stiffness, which is consistent with previous reports 30. Overall both equations showed significant associations with most of the major vascular risk markers.…”

Section: Discussionsupporting

confidence: 92%

Chronic kidney disease, cardiovascular risk markers and total mortality in older men: cystatin C versus creatinine

Zonoozi¹,

Ramsay

Papacosta

et al. 2019

J Epidemiol Community Health

View full text Add to dashboard Cite

BackgroundIt remains uncertain whether cystatin C is a superior marker of renal function than creatinine in older adults. We have investigated the association between estimated glomerular filtration rate (eGFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations based on creatinine (CKD-EPIcr) and cystatin C (CKD-EPIcys), and cardiovascular risk markers and mortality in older adults.MethodsThis is a cross-sectional and prospective study of 1639 British men aged 71–92 years followed up for an average of 5 years for mortality. Cox survival model and receiving operating characteristic analysis were used to assess the associations.ResultsThe prevalence of chronic kidney disease (CKD) was similar using the two CKD-EPI equations, although cystatin C reclassified 43.9% of those with stage 3a CKD (eGFR 45–59 mL/min/1.732, moderate damage) to no CKD. However, CKD stages assessed using both CKD-EPIcr and CKD-EPIcys were significantly associated with vascular risk markers and with all-cause and cardiovascular disease mortality. In all men with CKD (eGFR <60 mL/min/1.732), the HRs (95% CI) for all-cause mortality after adjustment for cardiovascular risk factors compared with those with no CKD were 1.53 (1.20 to 1.96) and 1.74 (1.35 to 2.23) using CKD-EPIcr and CKD-EPIcys, respectively. Comparisons of the two CKD equations showed no significant difference in their predictive ability for mortality (difference in area under the curve p=0.46).ConclusionDespite reclassification of CKD stages, assessment of CKD using CKD-EPIcys did not improve prediction of mortality in older British men >70 years. Our data do not support the routine use of CKD-EPIcys for identifying CKD in the elderly British male population.

show abstract

Section: Discussionsupporting

confidence: 92%

Chronic kidney disease, cardiovascular risk markers and total mortality in older men: cystatin C versus creatinine

Zonoozi¹,

Ramsay

Papacosta

et al. 2019

J Epidemiol Community Health

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus, chronic glomerulonephritis and hypertension were the major aetiology of renal disease, accounting for 30(37.5%), 24 (Table 3). On multiple linear regression analysis, the significant predictors of elevated serum CRP in the CKD patients were low eGFR (p = 0.03) and high BMI (p = 0.03) ( Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…[11][12][13] Its level correlates with carotid intima media thickness in CKD patients, hence can serve as a biomarker to estimate cardiovascular risk. 24 C-reactive protein has also been implicated as an actual promoter of atherosclerotic disease progression by binding to LDL, facilitating its deposition on the arterial wall and activating the complement system. 25,26 The median serum level of hsCRP was significantly higher in the CKD group compared to the controls who did not have CKD.…”

Section: Discussionmentioning

confidence: 99%

“…The wells were later washed for 5 times with distilled water and properly dried by striking sharply on absorbent paper. 100µl of tetremethylbenzidine solution was then added to each well, gently mixed for 5 seconds and incubated at [20][21][22][23][24][25] 0 C for 20 minutes. Thereafter, 100µl of 1N hydrochloric acid (stop solution) was added to each well, gently mixed for 30 seconds to stop the reaction and for the development of a yellow colour, the absorbance which was read with a microtitre well reader at 450 nm within 15 minutes.…”

Section: C-reactive Protein Assaymentioning

confidence: 99%

See 1 more Smart Citation

Serum C-reactive protein levels in pre-dialysis chronic kidney disease patients in southern Nigeria

Adejumo¹,

Okaka²,

Okwuonu³

et al. 2016

Ghana Medical Journal

View full text Add to dashboard Cite

SUMMARYBackground: Cardiovascular disease is the major cause of hospitalization and mortality in chronic kidney disease (CKD). C-reactive protein (CRP) is a marker of cardiovascular disease and predictor of mortality in CKD patients. CKD patients with elevated CRP should be identified early with institution of measures to treat cardiovascular risk factors in order to reduce attendant mortality. Aims: Determination of serum CRP levels in CKD patients and associated factors. Methods: This was a case-control study involving 80 consecutive CKD patients and 40 control subjects without CKD. Data obtained from participants included demographics, body mass index (BMI), and aetiology of CKD. Serum CRP levels, albumin, creatinine and lipid profile were determined. Cases and controls were compared. P values <0.05 were taken as significant Results: The mean age of the CKD subjects was 49.09±16.85 years. The median CRP value was significantly higher in the CKD group compared to controls (p=<0.001). Low, average and high cardiovascular event risk according to CRP values were present in 51(63.8%), 13(16.2%) and 16(20%) of the CKD patients respectively. Cardiovascular event risk was significantly higher in CKD subjects (p=<0.001). Serum creatinine, BMI, triglyceride and atherogenic index of plasma correlated positively with CRP. Estimated glomerular filtration rate (eGFR), high density lipoprotein-cholesterol and albumin correlated negatively with CRP. Elevated serum CRP was significantly predicted by low eGFR and high BMI on multivariate analysis. Conclusion: Chronic kidney disease patients have increased cardiovascular event risk. Interventions aimed at reducing weight and treating dyslipidaemia should be instituted early in order to reduce this risk.

show abstract

“…In the same line of reasoning, Günal et al (2006) showed a decrease in cIMT with an strict volume control in HD patients, a fact that has not been proven to be true in PD patients (Hiramatsu et al, 2007). As a last hypothesis for the increased cIMT in HD patients, there is the possibility that the previously described increased levels of pro-BNP in HD patients (Nakatani et al, 2002; Al-Hweish et al, 2010; Sanjuan et al, 2011) could favor an increased cIMT, as it has been published for CKD patients (DeFilippi et al, 2005; Sathi et al, 2014); a similar effect has been described for Troponins (Al-Hweish et al, 2010; Caliskan et al, 2012).…”

Section: Discussionmentioning

confidence: 63%

Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease

et al. 2018

View full text Add to dashboard Cite

Carotid intima media thickness (cIMT) displays prognostic value as a marker of cardiovascular risk in dialysis patients. However, few data are available regarding the impact of dialysis modality on cIMT. The aim of this study is to determine whether the modality of dialysis influences cIMT values. We compared 237 peritoneal dialysis (PD) and 451 hemodialysis (HD) patients without previous cardiovascular disease included in NEFRONA, a prospective, observational and multicenter study. This cross sectional study included the determination of cIMT in 6 carotid territories by arterial ultrasound. cIMT was determined in territories without atheroma plaque and averaged. A second analysis was performed using all territories, giving a truncated cIMT value of 1,5 mm to territories presenting with atheroma plaque. Age and plaque presence at baseline were the clinical variables more closely associated to cIMT in dialysis patients. The evaluation of the impact of the modality of dialysis on cIMT showed that PD patients had lower cIMT than HD patients, both in territories with no plaques and when using truncated cIMT values. No differences were found between right and left sides, neither in cIMT or truncated cIMT values. Lineal multivariate analysis adjusted by several clinical variables showed a statistically significant association of PD with a lower cIMT (slope -0.036; SD 0.010). These results were also confirmed when truncated cIMT values were used. We conclude that the modality of dialysis has an impact on cITM. HD patients have greater global cIMT than PD patients, and PD is and independent factor associated with a lower cIMT.

show abstract

Nontraditional Cardiovascular Biomarkers and Estimation of Cardiovascular Risk in Predialysis Chronic Kidney Disease Patients and Their Correlations With Carotid Intima Media Thickness

Cited by 8 publications

References 37 publications

Chronic kidney disease, cardiovascular risk markers and total mortality in older men: cystatin C versus creatinine

Chronic kidney disease, cardiovascular risk markers and total mortality in older men: cystatin C versus creatinine

Serum C-reactive protein levels in pre-dialysis chronic kidney disease patients in southern Nigeria

Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease

Contact Info

Product

Resources

About