Nontoxic Metal-Free Visible Light-Responsive Carbon Nitride Quantum Dots Cause Oxidative Stress and Cancer-Specific Membrane Damage

Yadav, Pranjali; Mimansa,; Kailasam, Kamalakannan; Shanavas, Asifkhan

doi:10.1021/acsabm.1c01219

Cited by 10 publications

(5 citation statements)

References 46 publications

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“…These observations were well supported by the preferential uptake of Au NCs by cancer cells compared to normal cells (Figure C) and eventual generation of significant intracellular ROS (Figure D), leading to exclusive activation of programmed cell death (Figure E). Prior reports have linked oxidative stress and apoptosis via endoplasmic reticulum dysfunction and a decrease in the mitochondrial membrane potential leading to apoptosis. , The observed cancer-specific oxidative stress agrees with previous reports on H 2 O 2 -mediated toxicity of copper-chelated d -penicillamine against breast cancer and leukemic cells. , …”

Section: Resultssupporting

confidence: 90%

Penicillamine-Capped Red-Emitting Gold Nanoclusters for Therapeutic Application

Bain¹,

Mimansa²,

Devi³

et al. 2022

ACS Sustainable Chem. Eng.

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Subnanometer-sized metal nanoclusters (NCs) with diameters <2 nm have emerged as promising materials in biomedical applications. Here, we report the synthesis of near-infrared (NIR)-emitting Au 14 nanoclusters using a small therapeutic molecule, D-penicillamine (DPA), as a surface stabilizing agent. We have characterized the morphology and composition of as-synthesized NCs using electron microscopy and mass spectrometry techniques. The photophysics of the NCs was investigated by UV−vis and photoluminescence (PL) spectroscopy. We found molecule-like features with three distinctive absorption bands at 390, 456, and 590 nm and a photoemission band at 696 nm. We observed that Au NCs specifically inhibited cancer cells dose-dependently through preferential uptake and imparted significant intracellular ROS. They did not show any acute toxicity in C57BL/6 mice at a dosage of 10 mg/kg, with predominant accumulation in the kidneys at the end of 24 h.

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Section: Resultssupporting

confidence: 90%

Penicillamine-Capped Red-Emitting Gold Nanoclusters for Therapeutic Application

Bain¹,

Mimansa²,

Devi³

et al. 2022

ACS Sustainable Chem. Eng.

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“…Cell culture, in vitro biocompatibility, cellular uptake, in vitro reactive oxygen species (ROS) generation, in vitro photodynamic therapy, live/dead cell staining assay, annexin V apoptosis assay, and cell cycle analysis were performed as reported elsewhere. , …”

Section: Methodsmentioning

confidence: 99%

Gold–BODIPY Nanoparticles with Luminescence and Photosensitization Properties for Photodynamic Therapy and Cell Imaging

Rahman¹,

Kumar²,

Yadav³

et al. 2022

ACS Appl. Nano Mater.

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Coupling of surface plasmons on metal nanoparticles with the electronic states of organic chromophores is known to result in hybrid states having unique photophysical properties. Previously, we had demonstrated that plasmon–molecule coupling in gold–BODIPY nanocomposites was effective for singlet oxygen production for photodynamic therapy (PDT). Herein, we show that gold nanoparticles can function as a matrix on which Förster resonance energy transfer (FRET) is facilitated between two electronically distinct BODIPY chromophores in a multichromophoric nanocomposite, which opens up radiative pathways, thereby making the nanocomposite fluorescent. Additionally, photoinduced hot electron transfer between BODIPY and gold allows for the efficient photosensitized generation of singlet oxygen. Our approach to achieving simultaneous FRET and plasmon–molecule interactions on gold nanoparticles is unique and hitherto unknown and makes the multichromophoric nanocomposite a potential candidate for photodynamic therapy and cell imaging.

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“…In modern society, a crowd of dangerous hazards irreversibly harm human health even at extremely low levels of exposure, especially heavy metal ions and viruses. [444,465,466] Therefore, a sensitive, real-time, and rapid detection of these viruses and toxic ions has become urgent to protect human health from unintentional exposure to these hazards. Using metal-free materials to detect their concentration is appropriate since it does not induce any secondary contamination to tested samples.…”

Section: Sensormentioning

confidence: 99%