Nonsyndromic type of hereditary multiple basal cell carcinoma

Abstract

An autosomal dominant phenotype characterized by multiple superficial basal cell carcinomas (BCC) without associated anomalies is postulated on the ground of the following data. There are several reports on multiple BCC occurring in two generations of a family, including male-to-male transmission. There are also three reports of a strictly unilateral manifestation of multiple superficial BCC, suggesting mosaicism. The father of one of the patients with unilateral involvement was affected with multiple disseminated BCC, which suggests a type 2 segmental manifestation in the son, reflecting loss of heterozygosity that occurred at an early stage of embryogenesis. The three cases of unilateral arrangement would be difficult to explain without the assumption that multiple nonsyndromic superficial BCC may occur as a distinct mendelian trait.

A Case of Multiple Unilateral Localized Basal Cell Carcinomas

“…In addition, it is of interest that the three BCCs in our case were noted in one and a half years and that they were located only on a band-like area of the right half of her trunk. Multiple BCCs with a segmental manifestation have been reported occasionally in the literature (4)(5)(6). The present case can be explained by chance, but these lesions seemed to follow the lines of Blaschko.…”

Basal Cell Carcinoma: A Case Report

“…Patient with this condition usually presents with a broad nasal root, low intelligence, multiple jaw cysts, palmar pits, bilamellar clarification in falx cerebri and multiple skeletal abnormalities along with multiple BCCs. 5 In this patient, which pointed towards BCC, we had ruled out the possibility of all the syndrome on history, clinical examination and investigations and then was operated and managed with wide excision and full thickness skin graft.…”

Multiple Rumpfhautbasaliome nach langjähriger Einnahme von arsenhaltigem Natriumhydrogenkarbonat

“…Differenzialdiagnostisch noch in Erwägung zu ziehen wäre der von Happle [9] beschriebene nonsyndromische Typ hereditärer multipler Basaliome. Hierbei finden sich familiär auftretende, oberflächliche, bevorzugt am Stamm lokalisierte Basaliome ohne assoziierte Anomalien.…”