Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis

Cardoso, E-F; Martelli, D-R-B; Machado, R-A; Coletta, Ricardo D.; Souza, J-D de; Barbosa, F-T; Figueiredo, M-F-L de; Coelho, L-G-V; Martelli‐Júnior, Hercílio

doi:10.4317/medoral.22132

Cited by 7 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The history of NSCL/P was about 3% in both groups. In conclusion, they found no increase in the frequency of tooth agenesis in patients with gastric cancer, or in the frequency of NSCL/P in the first‐degree relatives of gastric cancer patients 75 …”

Section: Tooth Agenesis As a Predictive Marker For Cancermentioning

confidence: 73%

See 1 more Smart Citation

Tooth agenesis: What do we know and is there a connection to cancer?

et al. 2021

View full text Add to dashboard Cite

Like all developmental processes, odontogenesis is highly complex and dynamically regulated, with hundreds of genes co‐expressed in reciprocal networks. Tooth agenesis (missing one or more/all teeth) is a common human craniofacial anomaly and may be caused by genetic variations and/or environmental factors. Variants in PAX9, MSX1, AXIN2, EDA, EDAR, and WNT10A genes are associated with tooth agenesis. Currently, variants in ATF1, DUSP10, CASC8, IRF6, KDF1, GREM2, LTBP3, and components and regulators of WNT signaling WNT10B, LRP6, DKK, and KREMEN1 are at the forefront of interest. Due to the interconnectedness of the signaling pathways of carcinogenesis and odontogenesis, tooth agenesis could be a suitable marker for early detection of cancer predisposition. Variants in genes associated with tooth agenesis could serve as prognostic or therapeutic targets in cancer. This review aims to summarize existing knowledge of development and clinical genetics of teeth. Concurrently, the review proposes possible approaches for future research in this area, with particular attention to roles in monitoring, early diagnosis and therapy of tumors associated with defective tooth development.

show abstract

Section: Tooth Agenesis As a Predictive Marker For Cancermentioning

confidence: 73%

“…In addition to family and association studies, epidemiological data on tooth agenesis and cancer were collected in five original articles 71‐75 (discussed below) and four reviews 76‐79 . However, these reviews are based only on epidemiological data of mentioned five sources.…”

Section: Tooth Agenesis As a Predictive Marker For Cancermentioning

confidence: 99%

Tooth agenesis: What do we know and is there a connection to cancer?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The association between AXIN2 and gastric cancer has been reported, 34 but the association between hypodontia and gastric cancer has not been demonstrated. 15,35 Predisposition to CRC is reported with greater frequency in patients with severe oligodontia and it is directly related to the loss of AXIN2 function. In the same context, dental agenesis had been proposed as a risk marker related for ovarian epithelial cancer.…”

Section: Discussionmentioning

confidence: 99%

Variations in AXIN2 predict risk and prognosis of colorectal cancer

et al. 2019

View full text Add to dashboard Cite

Objective Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC. Patients and methods This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis. Results AXIN2 rs2240308 showed association with CRC (OR = 5.4 CI: 2.7–10.4; p < 0.001) and with other familial cancer in individuals with hypodontia (p < 0.005 OR = 1.75, 95% CI: 1.22–6.91). In silico analysis showed that variations in AXIN2 found in CRC patients, were more frequently in earlier stages of tumor and patients who carry variations in the AXIN2 gene have a worse prognosis (p < 0.05). The association between AXIN2 rs2240308 with hypodontia was not significant. Conclusions These results suggest that AXIN2 rs2240308 polymorphism is associated with CRC and AXIN2 could be a risk marker for predisposition and prognosis of CRC.

show abstract

“…Although multiple candidate genes and genetic loci conferring susceptibility to NSOC have been associated with cancer risk [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], the genetic pathways underlying cancer and birth defects remain to be identified. Interestingly, NSOC is ultimately caused by interferences in cell proliferation, differentiation, survival, adhesion and migration, all of which are known to be involved in cancer [4].…”

Section: Discussionmentioning

confidence: 99%

“…The concept is that genes acting during the normal development may also have an important role in malignancies [6]. Over the past years, epidemiological studies have investigated the association of cancer with NSOC in different populations, including those from the United States, Southeast Asia, Denmark, Latvia, India, the Netherlands, Turkey, France, Poland, Pakistan, and Brazil [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], and the results are controversial. Thus, the aim of this study was to determine the frequency of NSOC in families of patients with a diagnosis of ALL.…”

Section: Introductionmentioning

confidence: 99%

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

et al. 2020

View full text Add to dashboard Cite

Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher’s exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61–274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

show abstract

Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis

Cited by 7 publications

References 29 publications

Tooth agenesis: What do we know and is there a connection to cancer?

Tooth agenesis: What do we know and is there a connection to cancer?

Variations in AXIN2 predict risk and prognosis of colorectal cancer

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

Contact Info

Product

Resources

About