Nonsurgical, radiofrequency collagen denaturation for stress urinary incontinence: retrospective 3-year evaluation

Appell, Rodney A.; Singh, G. S.; Klimberg, Ira; Graham, Cynthia A.; Juma, Saad; Wells, W. Glen; Kanellos, Angelo; Reilley, Sandra F.

doi:10.1586/17434440.4.4.455

Cited by 20 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All cases of dysuria, hematuria, and hesitancy were transient and mild to moderate, and all urinary tract infections were simple and resolved with antibiotic therapy [ 21• ]. No new AEs were reported in the 36-month follow-up analysis from this study [ 29 ].…”

Section: Safetymentioning

confidence: 62%

“…A recent retrospective study assessed the long-term efficacy of the transurethral collagen denaturation procedure in patients who participated in the 12-month, sham-controlled trial [ 29 ]. In total, 26 patients were available for evaluation at least 3 years after undergoing the procedure.…”

Section: Long-term Durabilitymentioning

confidence: 99%

“…Of the fi ve study sites that did participate, 50% of patients were available for follow-up. Of these patients, fi ve (19%) had undergone additional treatment for SUI and were therefore not included in the analysis [ 29 ]. The mean baseline I-QOL score was 56.3, and after 3 years, the mean improvement over baseline was 12.7 points ( P = 0.04).…”

Section: Long-term Durabilitymentioning

confidence: 99%

See 2 more Smart Citations

Transurethral collagen denaturation for women with stress urinary incontinence

Appell

2008

Curr Urol Rep

View full text Add to dashboard Cite

Transurethral collagen denaturation was approved by the US Food and Drug Administration in 2005 for the nonsurgical treatment of stress urinary incontinence in women. In this procedure, controlled, nonablative radiofrequency energy applied through a transurethral probe produces microscopic submucosal sites of collagen denaturation, resulting in reduced tissue compliance. Treatment is administered in about 30 minutes in an outpatient setting without incisions, general anesthesia, or use of cystoscopy or other visualization. The safety and efficacy of this treatment were demonstrated in a pilot trial in 41 women and then in a subsequent 12-month sham procedure-controlled trial in more than 170 women. Ongoing clinical trials include a 3-year, open-label durability study and an evaluation of this technique in women who have failed prior surgical intervention. To date, patients who received transurethral collagen denaturation have experienced improvements in quality of life and in Valsalva leak point pressure. This procedure presents a beneficial nonsurgical treatment option for women with stress urinary incontinence.

show abstract

Section: Safetymentioning

confidence: 62%

Section: Long-term Durabilitymentioning

confidence: 99%

Section: Long-term Durabilitymentioning

confidence: 99%

See 1 more Smart Citation

Transurethral collagen denaturation for women with stress urinary incontinence

Appell

2008

Curr Urol Rep

View full text Add to dashboard Cite

show abstract

“…The concept of bulking agents and the application of radiofrequency are also being evaluated, although bulking agents require additional surgical revisions, and recent reports of radiofrequency micro-remodeling are less than encouraging [12][13][14][15][16] . The artificial urinary sphincter, whilst a much more invasive treatment option, yields excellent results within a well-defined group of patients but has a significant revision rate as a result of erosion, particularly in females [17,18] .…”

Section: Discussionmentioning

confidence: 99%

Adjustable Continence Therapy for Female Urinary Incontinence: A Minimally Invasive Option for Difficult Cases

Wachter

Henning²,

Roehlich³

et al. 2008

Urol Int

View full text Add to dashboard Cite

Aim: To assess the role of Adjustable Continence Therapy® (ACT) as a minimally invasive treatment for women with urinary incontinence (UI) after failed previous incontinence surgery or when conventional surgical treatment was considered problematic. Material and Methods: The ACT device consists of two balloons implanted at the level of the bladder neck using a paraurethral/vaginal approach with the aim of coapting the urethra. Balloon filling can be adjusted postoperatively via a port placed in the labia majora. Results: 41 women with a mean age of 73 (range 42–93) years were evaluated. 15 (38%) women had failed previous UI surgery with 83% having undergone prior pelvic surgery. Mean follow-up was 25 (5–60) months. Adjustment of the ACT balloons was necessary in 28 women (69%). Overall, 44% of women became fully continent, 15% reported a significant improvement of UI, a further 29% had a slight improvement, while 12% indicated no change. ACT-related complications occurred in 16 (39%) patients, including balloon migration, transient urinary obstruction and balloon leakage. Conclusions: ACT is an attractive minimally invasive option for women with UI with previous failed incontinence surgery or when conventional incontinence surgery carries a high risk of failure.

show abstract

“…Recent developments in radiofrequency technology have created opportunities in controlled scarring of paraurethral tissue in an effort to create support for the hypermobile urethra. [53] The Renessa™ (Novasys Medical, Newark, CA) device uses radiofrequency to heat the inside of the urethra to treat mild SUI in an office setting. This procedure may provide “gap” coverage for women who want to delay definitive treatment of SUI that requires surgical intervention, or for women with just mild SUI, as the current results do not support its use in more severe SUI.…”

Section: Future Potentialmentioning

confidence: 99%

Stress urinary incontinence: What, when, why, and then what?

et al. 2011

View full text Add to dashboard Cite

Stress urinary incontinence (SUI) has a significant impact on the quality of life for many women. Most women do not seek medical attention for this condition. Treatment for this problem includes initial conservative therapies and then surgery is an option. More than 200 surgical procedures have been described in the literature for the treatment of stress incontinence. The gold-standard surgical treatment of SUI in patients with a mobile bladder neck and normally functioning urethra has been accomplished through a retropubic approach using either a Burch or Marshall-Marchetti-Krantz procedure. By the absolute success of Trans obturator tape (TOT) application in treatment of SUI and the niche it has created for itself in the maze of treatment modalities available for SUI, there seems to be little doubt that TOT is all set to become the new Gold Standard for treatment of SUI in times to come. It is difficult to imagine any further improvements in the midurethral sling procedures or surgeries for SUI. However 10 years ago, no one could have imagined the progress and development that has been seen over these few short years in the treatment of SUI. The future may hold promise in technologies such as stem cells that may be injected in or around the urethral support structures and provide regeneration of the lacking support structures. What so ever, it's definitely time to provide millions of women with knowledge that empowers them to make lifestyle changes to decrease their risk of SUI and to understand the reality that they are not alone if they have SUI.

show abstract

Nonsurgical, radiofrequency collagen denaturation for stress urinary incontinence: retrospective 3-year evaluation

Cited by 20 publications

References 15 publications

Transurethral collagen denaturation for women with stress urinary incontinence

Transurethral collagen denaturation for women with stress urinary incontinence

Adjustable Continence Therapy for Female Urinary Incontinence: A Minimally Invasive Option for Difficult Cases

Stress urinary incontinence: What, when, why, and then what?

Contact Info

Product

Resources

About