Nonsteroidal Antiinflammatory Drugs in Treatment of Osteoarthritis

Brandt, Kenneth D.; Slowman‐Kovacs, Sally D.

doi:10.1097/00003086-198612000-00011

Cited by 43 publications

(15 citation statements)

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“…Collier and Ghosh [18] reported that ketoprofen had no influence or only a slight one on the PG secretion of rabbit chondrocytes in culture, but in such a model the chondrocytes lack an extracellular matrix. Hence they could be more susceptible to possible degradative influences of NSAIDs as was described by Palmoski [16] and Brandt [19]. The varying responses of human osteoarthritic cartilage to ketoprofen in our study are not likely to be due to changes in the cartilage matrix as we did not find a relation between the effect of ketoprofen and the histological grade of the cartilage samples (Fig.…”

Section: Discussionsupporting

confidence: 47%

In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage

Wilbrink¹,

Veen²,

Huber³

et al. 1991

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We investigated the influences of ketoprofen on the proteoglycan (PG) turnover of human articular cartilage explants in three groups: normal young with a high basal PG synthesis, normal adult and osteoarthritis cartilage, both with a low basal PG synthesis. Ketoprofen had no influence on the mean PG synthesis rate of normal adult and OA cartilage after 4 days of culture nor on the cartilage PG content after 8 days of culture. There was no relation between the histological grade of OA and effects of ketoprofen. In normal young cartilage ketoprofen induced an increase of the PG synthesis rate when added to the culture in a concentration of 10(-4) M. No correlation existed between the effect of ketoprofen and the basal PG synthesis of normal cartilage.

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Section: Discussionsupporting

confidence: 47%

In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage

Wilbrink¹,

Veen²,

Huber³

et al. 1991

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“…Although it would have been possible to conduct more wide-ranging experiments on isolated human tenocytes similar to those used by Almekinders et al (1995) explant culture system retains the mixed tendon cell population within the normal matrix and is arguably a better model of the in vivo situation than monolayer cultures on plastic surfaces. Similarly, although more detailed studies could have been conducted on animal tendons, species-related differences in the responses to NSAIDs make any correlation with human tendon questionable (Brandt and Slowman-Kovacs, 1986). The differential effects of NSAIDs observed in our study were apparently unrelated to inhibition of cyclooxygenase and PG synthesis, and are likely to be a secondary effect of particular NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro

Riley

Cox

Harrall

et al. 2001

Journal of Hand Surgery

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The purpose of this study was to investigate the effects of some commonly used non-steroidal anti-inflammatory drugs (NSAIDs) on human tendon. Explants of human digital flexor and patella tendons were cultured in medium containing pharmacological concentrations of NSAIDs. Cell proliferation was measured by incorporation of 3H-thymidine and glycosaminoglycan synthesis was measured by incorporation of 35S-Sulphate. Diclofenac and aceclofenac had no significant effect either on tendon cell proliferation or glycosaminoglycan synthesis. Indomethacin and naproxen inhibited cell proliferation in patella tendons and inhibited glycosaminoglycan synthesis in both digital flexor and patella tendons. If applicable to the in vivo situation, these NSAIDs should be used with caution in the treatment of pain after tendon injury and surgery

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“…However, some of the NSAIDs do not affect-and others even stimulate-chondrocyte proteoglycan metabolism (1,(9)(10)(11)(12)15). Furthermore, the effect of some of these antiinflammatory compounds (indomethacin, piroxicam) have been shown to vary according to the species or the experimental model involved (9-12).…”

Section: Introductionmentioning

confidence: 99%

Proteoglycan Metabolism in Tissue-cultured Human Articular Cartilage: Influence of Niflumic Acid

Verbruggen

Veys

Malfait

et al. 1990

Scandinavian Journal of Rheumatology

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Proteoglycan metabolism was investigated in tissue-cultured human cartilage. Normal cartilage obtained from a normal joint showed improving accumulation rates for 35S-labelled proteoglycans over a 3-6 weeks' period. The loss of newly synthesized molecules in the nutrient media was low and constant throughout culture. A decrease in accumulation of 35S-proteoglycan was observed in visually intact cartilage from joints showing foci of osteoarthrosis. This decrease was more pronounced in fibrillated cartilage. No clear effect on proteoglycan metabolism was observed when normal cartilage samples from the normal joint were incubated for several weeks in a nutrient medium containing niflumic acid. However, the cartilage samples from this donor tended to retain more proteoglycan aggregates in the intercellular matrix after a 6-weeks culture period in the presence of this NSAID. When niflumic acid was added to the incubation media of visually intact samples from pathological joints, significantly more newly synthesized proteoglycans were retained in the intercellular matrix. The effect was also observed and was more pronounced in the fibrillated cartilage samples.

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Nonsteroidal Antiinflammatory Drugs in Treatment of Osteoarthritis

Cited by 43 publications

References 0 publications

In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage

In vitro influence of ketoprofen on the proteoglycan metabolism of human normal and osteoarthritis cartilage

Inhibition of Tendon Cell Proliferation and Matrix Glycosaminoglycan Synthesis by Non-Steroidal Anti-Inflammatory Drugs in vitro

Proteoglycan Metabolism in Tissue-cultured Human Articular Cartilage: Influence of Niflumic Acid

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