1987
DOI: 10.1016/0016-5085(87)90909-7
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Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans

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Cited by 337 publications
(159 citation statements)
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“…It has been reported that gold salts, which are disease-modifying anti-rheumatic drugs (DMARDs), frequently cause inflammation of the digestive organs (10)(11)(12). In addition, some non-steroidal anti-inflammatory drugs (NSAIDs) are thought to cause intestinal inflammation (13). In the present case, drug-induced colitis was not plausible because the drugs the patient had taken (other than diclofenac) have not been reported to cause colitis.…”
Section: Discussionmentioning
confidence: 64%
“…It has been reported that gold salts, which are disease-modifying anti-rheumatic drugs (DMARDs), frequently cause inflammation of the digestive organs (10)(11)(12). In addition, some non-steroidal anti-inflammatory drugs (NSAIDs) are thought to cause intestinal inflammation (13). In the present case, drug-induced colitis was not plausible because the drugs the patient had taken (other than diclofenac) have not been reported to cause colitis.…”
Section: Discussionmentioning
confidence: 64%
“…Measurement of inflammation is by qualitative indium-111-labeled neutrophil scintigraphy. In 50% of patients on NSAIDs for more than 6 months, this method of scintigraphy consistently shows accumulation of the labeled white cells on the terminal ileum, halted by the ileocecal valve, after 20 h [40]. The 4-day fecal excretion of 111 In also confirms low-level inflammation in NSAID users compared to that in inflammatory bowel disease.…”
Section: Diagnosis Of Nsaids-induced Small Intestinal Injurymentioning
confidence: 64%
“…In two retrospective studies of 268 and 188 patients, hospitalization due to intestinal perforations or hemorrhage were twice as likely to develop in patients on NSAIDs than in controls [30] . Bjarnason et al [31] reported that up to 70% of patients receiving long-term NSAID therapy, including diclofenac therapy, developed small intestinal NSAID enteropathy. Numerous studies have demonstrated that an increase in intestinal permeability is the central mechanism that translates biochemical damage to tissue damage in the pathogenesis of NSAID enteropathy.…”
Section: Discussionmentioning
confidence: 99%