Nonsteroidal anti‐inflammatory drugs enhance allergic reactions in a patient with wheat‐induced anaphylaxis

Abstract

References 1. Harada S, Horikawa T, Ashida M, Kamo T, Nishioka E, Ichihashi M. Aspirin enhances the induction of type I allergic symptoms when combined with food and exercise in patients with food-dependent exercise-induced anaphylaxis. Br J Dermatol 2001;145:336-339. 2. Aihara M, Miyazawa M, Osuna H, Tsubaki K, Ikebe T, Aihara Y et al. Food-dependent exercise-induced anaphylaxis: influence of concurrent aspirin administration on skin testing and provocation. Br J Dermatol 2002;146:466-472. 3. Wojnar RJ, Hearn T, Starkweather S.Augmentation of allergic histamine release from human leukocytes by nonsteroidal anti-inflammatory-analgesic agents.

Two cases of wheat-dependent anaphylaxis induced by aspirin administration but not by exercise

“…In contrast to reports on WDEIA, there have been only a few reports of wheat‐dependent anaphylaxis induced by aspirin and NSAIDs but not induced by wheat and exercise 10,11 . We report two cases of wheat‐dependent anaphylaxis that was not induced by the combination of wheat and exercise but was induced by wheat and aspirin, a condition we term wheat‐dependent aspirin‐induced anaphylaxis (WDAIA).…”

“…The mechanism by which WDEIA is enhanced by NSAIDs has not been elucidated. It is possible that when patients are exposed to food to which they have been sensitized, aspirin may lower the threshold of mast‐cell histamine release, as it has been shown that NSAIDs enhance in vitro histamine release induced by IgE‐mediated mechanisms 11,12 . Recently, Matsuo et al.…”

PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia

“…In clinical settings, administration of nonsteroidal antiinflammatory drugs, especially aspirin, is well known to enhance type I allergic reactions in the respiratory or GI tract 42,43 . Several studies have shown that aspirin enhances histamine and/or cys-LTs release from human leukocytes including mast cells [44][45][46] .…”

Nonsteroidal anti‐inflammatory drugs enhance IgE‐mediated activation of human basophils in patients with food anaphylaxis dependent on and independent of nonsteroidal anti‐inflammatory drugs

“…The spectrum of foods involved in FDNIA is wide (wheat, nuts, seeds, shellfish) [12][13][14][15][16] and seems to have a geographical pattern. Whereas in Japan gliadins from wheat are involved in most cases [12,17,18], lipid transfer proteins (LTPs) from plant foods have been recently reported as major culprit allergens in the Mediterranean area [13,14,19].…”