Nonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal Disease

Abstract

Regular use of NSAIDs may increase the risk for chronic kidney disease in some high-risk groups. With the recent over-the-counter availability and increasing popularity of NSAIDs, the possibility of an increased risk for chronic renal disease associated with their use may warrant further scrutiny.

Direct toxicity of nonsteroidal antiinflammatory drugs for renal medullary cells

“…The mixtures often also contained caffeine. Interestingly, in some epidemiological studies caffeine content was the best predictor for subsequent renal failure (5,6). The renal medullary toxicity of these particular analgesic drugs was apparently supported by animal studies, but interpretation of both the epidemiological and animal studies has been questioned (7)(8)(9).…”

Inappropriate use of nonsteroidal anti-inflammatory drugs and other drugs in chronic kidney disease patients without renal replacement therapy

“…1 The nonsteroid antiinflammatory drugs use was even associated with a twofold increase in CKD risk in individuals over 65. 23 Although it has been known that nonsteroid anti-inflammatory drugs inhibit the therapeutic effects of ACE inhibitors, a group of CKD patients in our study was using ACE inhibitors and NSAIDs at the same time. 13 Making required behavioral modifications, e.g., avoiding or restricting the use of NSAIDs, is important for preventing the progress of CKD.…”

“…13 Some case control studies have disclosed that the NSAID use increases the risk of progress to the end-stage kidney failure. 13,23,24 The frequent use of NSAIDs is mainly related to joint diseases such as osteoarthritis, resulting from degenerative disorders that become more common with aging. The use of NSAIDs in these patients improves life quality; however, the risk of renal damage should be taken into consideration.…”

“…That is why inappropriate drug use in patients with CKD may cause adverse effects on patients and progression of chronic renal failure. [8][9][10][11] Conservative therapy is also used for treatment and prevention of progression of the disease. One of the most important factors influencing the success of conservative therapy is detecting and eliminating predisposing factors.…”

Chronic Renal Disease in Kuwaiti Nationals: A Prospective Study During the Past 4 Years

“…Forty percent of our patients developed at least one episode of acute renal failure (ARF), which confirms the high prevalence of ARF in patients with CRD. [28] Fortunately, a large proportion was due to remediable etiologies, such as drug side effects, especially the nonsteroidal antiinflammatory drugs, [29] and volume depletion. The latter fact emphasizes the effect of such common ''over-the-counter medications'' on CRD patients, with the major negative impact being on the patients' health, disease progression, and governmental recourses in management.…”