Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population

Huerta, Consuelo; Castellsagué, Jordi; Varas‐Lorenzo, Cristina; Rodrı́guez, Luis A. Garcı́a

doi:10.1053/j.ajkd.2004.12.005

Cited by 298 publications

(210 citation statements)

References 21 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…However, the ketoprofenG mean clearance values at T5 and T10 were below the normal range for dogs (Table 1). Reference ranges: Urea = 21-60 (mg/dL); Creatinine = 0.5-1.6 (mg/dL) [8]. Serum Sodium = 145-158 (mEq/L); Serum Potassium = 4.1-5.5 (mEq/L) [23].…”

Section: Resultsmentioning

confidence: 99%

“…For In patients with glomerular disease, inhibition of PG synthesis by NSAIDs can lead to a reversible renal ischemia, a decline in glomerular hydrostatic pressure and ARF 20 , since the increased production of PGs seems to keep GFR in the presence of a significant reduction in glomerular capillary permeability 8 . In this study, there were no significant changes in relation to renal markers.…”

Section: Discussionmentioning

confidence: 99%

“…These effects are strictly related to the reduction in prostaglandin (PG) synthesis induced by NSAIDs. The vasodilating effect of PGs plays a role in preservation of renal blood flow and glomerular filtration rate by relaxing the preglomerular resistance 8 .…”

Section: Most Of Nsaids Collateral Effects Are Attributed Tomentioning

confidence: 99%

See 2 more Smart Citations

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

View full text Add to dashboard Cite

PURPOSE:To evaluate the renal function in healthy dogs submitted to nonselective and preferential COX-2 nonsteroidal antiinflammatory drug (NSAID) therapy. METHODS:Twenty four healthy dogs were distributed into four groups (G) (n=6): ketoprofenG -treated with ketoprofen; nimesulideG -treated with nimesulid; meloxicanG -treated with meloxican; and etodolacG -treated with etodolaco. All the dogs received the NSAIDs for 10 days by oral route. Physical examination and renal function (urinalysis, urinary sodium and gamma-glutamyl transpeptidase (GGT), serum urea, creatinine, potassium and sodium, and endogenous creatinine clearance) were evaluated before, after five and ten days (T0, T5 and T10) of the treatment in all groups. RESULTS:Changes were observed in urinalysis, with a significant increase in renal cells in the urine at T5 and T10 in nimesulideG.Significant reduction in urinary sodium in nimesulideG at T5 was observed. The clearance values were lower in ketoprofenG at T10. CONCLUSIONS:Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Em pacientes com doença glomerular, a inibição da síntese de PGs por AINES pode levar à isquemia renal reversível, declínio da pressão hidrostática glomerular e insuficiência renal aguda (IRA) (ROSE, 2007), uma vez que, nesses pacientes, o aumento na produção de PGs parece manter a taxa de filtração glomerular na presença de importante redução na permeabilidade do capilar glomerular (HUERTA et al, 2005). Desse modo, deve-se ter máxima cautela ao fazer uso do celecoxibe em pacientes com doenças renais pré-existentes.…”

Section: Discussionunclassified

“…Atuam inibindo a síntese de mediadores químicos, basicamente atuando na inibição Ciência Rural, v.42, n.10, out, 2012. da enzima cicloxigenase (COX), que acarretará na diminuição de endoperóxidos cíclicos, tais como prostaglandinas (PG), prostaciclinas e tromboxanos (TX), importantes na mediação da dor e inflamação (JERICÓ & ANDRADE, 2008). Várias são as ações terapêuticas dos AINEs, de caráter periférico, como as ações anti-inflamatórias, analgésicas, antitrombóticas e antiendotóxicas, ou sobre o sistema nervoso central (SNC), promovendo ação antipirética e também analgésica (KUMMER & COELHO, 2002).…”

Section: Introductionunclassified

Função renal, hepática e cardíaca de cães hígidos sob terapia prolongada com celecoxibe

et al. 2012

View full text Add to dashboard Cite

show abstract

Frequency and Associations of Prescription Nonsteroidal Anti-inflammatory Drug Use Among Patients With a Musculoskeletal Disorder and Hypertension, Heart Failure, or Chronic Kidney Disease

et al. 2018

View full text Add to dashboard Cite

societies advise against nonsteroidal anti-inflammatory drug (NSAID) use in patients with hypertension, heart failure, or chronic kidney disease (CKD); however, recent studies have not investigated the frequency or associations of use in these patients.OBJECTIVES To estimate the frequency of and variation in prescription NSAID use among high-risk patients, to identify characteristics associated with prescription NSAID use, and to investigate whether use is associated with short-term, safety-related outcomes. DESIGN, SETTING, AND PARTICIPANTSIn this retrospective cohort study, administrative claims databases were linked to create a cohort of primary care visits for a musculoskeletal disorder involving patients 65 years and older with a history of hypertension, heart failure, or CKD

show abstract

Nonsteroidal anti-inflammatory drugs and risk of ARF in the general population

Cited by 298 publications

References 21 publications

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Função renal, hepática e cardíaca de cães hígidos sob terapia prolongada com celecoxibe

Frequency and Associations of Prescription Nonsteroidal Anti-inflammatory Drug Use Among Patients With a Musculoskeletal Disorder and Hypertension, Heart Failure, or Chronic Kidney Disease

Contact Info

Product

Resources

About