Nonsteroidal Anti-inflammatory Drug Use Is a Significant Cause of Peptic Ulcer Disease in a Tertiary Hospital in Singapore: A Prospective Study

Ong, Tze-Zen; Hawkey, Chris J.; Ho, Khek‐Yu

doi:10.1097/01.mcg.0000225610.41105.7f

Cited by 26 publications

(30 citation statements)

References 13 publications

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“…A similar observation has been reported in several other Asian studies (28,29). In the first period of the present study, we noted that the rate of GU was almost 2-fold higher compared with DU-consistent with the results of previous studies in Japan (30,31).…”

Section: Discussionsupporting

confidence: 82%

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

et al. 2011

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Background and Aims In Japan, the prevalence of Helicobacter pylori infection has decreased recently, but there has been little longitudinal research on the changes of symptoms and endoscopic findings over many years. The aim of this study was to evaluate the changes in endoscopic findings and symptoms over time in patients undergoing upper gastrointestinal endoscopy for assessment of upper abdominal symptoms. Methods Over a period of 25 years, between 1981 and 2005, we performed three investigations (1981-2, 1990-1 and 2004-5) on the symptoms and endoscopic findings of patients undergoing endoscopy at Kawasaki Medical School Hospital for the assessment of upper abdominal symptoms. Results The most common complaint for all ages was "discomfort and/or pain". Over time, the percentage of patients complaining of "heartburn" increased almost 5-fold. With respect to endoscopic findings, the prevalence of peptic ulcers decreased, whereas the detection of no abnormalities and the detection of erosive esophagitis increased. Conclusion In the future in Japan, there will be fewer patients with peptic ulcers and more patients with gastro-esophageal reflux disease or dyspeptic patients who display no endoscopic abnormal findings.

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Section: Discussionsupporting

confidence: 82%

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

et al. 2011

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“…This may have been because of increased use of NSAIDs among the elderly, despite the eradication of H. pylori 19,20. NSAIDs related ulcers are known to be prevalent among elderly individuals with a co-morbid illness, who are known to be more prone to gastric ulcers than duodenal ulcers, which have a greater tendency to bleed than H. pylori ulcers 21. The present study also shows that the average age of peptic ulcer patients has increased.…”

Section: Discussionmentioning

confidence: 52%

Trends of Gastrointestinal Diseases at a Single Institution in Korea over the Past Two Decades

Kwon

Choi²,

Lee³

et al. 2009

Gut Liver

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Background/AimsThe lifestyle changes that have accompanied economic growth have influenced disease patterns in Korea. Changing patterns of gastrointestinal (GI) diseases over the past two decades were investigated in the present study.MethodsData from inpatients with specific GI diseases, as defined by the International Classification of Diseases code, were extracted from the database at a tertiary medical facility for 1990, 1996, and 2006.ResultsAdmission rates for GI diseases increased between 1990 and 2006. The most prevalent disease in 1990 was gastric cancer, followed by appendicitis and colorectal cancer. However, by 2006, gastric cancer, colon cancer, and colon adenoma or polyps had become the most prevalent diseases. Although gastric cancer showed a decreasing trend, the rate of colon cancer doubled over two decades. Furthermore, rates of detection and endoscopic treatment of early gastric cancer and adenoma of the stomach and colon have increased noticeably. Newly emerging diseases include inflammatory bowel disease and gastroesophageal reflux. There was no change in the incidence of peptic ulcer, but ulcer-related complications and the numbers treated surgically decreased.ConclusionsThe findings of this study indicate that the clinical trends of GI diseases in Korea have changed in a similar way to those in the West. Early detection of a GI neoplasm will continue to increase with the establishment of cancer-screening programs, resulting in a rising need for minimally invasive treatments.

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“…One of the study showed that a high prevalence of occult non steroid antiinflammatory drug usages was found in H. pylori negative (PUD) patients which was based on elevated serum thromboxane. [16] In our study, 50% patients had non H. pylori PUD which might be the NSAID usages but we were not able to assess the association between NSAID and non H. pylori PUD because of incomplete data. In the present study, the commonest histopathological finding was gastritis (n = 158, 61.7%).…”

Section: Discussionmentioning

confidence: 98%

Prevalence of Helicobacter Pylori among Patients undergoing Gastrodudenoscopy in a Hospital in Western Nepal

Shakya¹,

Regmi²,

Adhikari³

2017

J Lumbini Med Coll

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Introduction: Helicobacter pylori (H. pylori) related chronic gastritis is a major health problem worldwide, specially in the developing countries. The prevalence of H. pylori infection has been reported to vary between and even within countries. There are limited data on this infection in Western Nepal. Our objective was to study the prevalence of H. pylori infection and its association with presenting complains and upper gastrointestinal diseases. Methods: Medical records of patients undergoing gastrodudenoscopy and biopsy for various upper gastrointestinal symptoms from 1st of January 2015 to 30th of June 2017 were reviewed for presence of H. pylori infection, demographics, indications for gastrodudenoscopy, and histopathology findings. T-test, Chi-square test, and Fisher exact test were applied. Results: Two hundred fifty six patients (135 male and 121 female) with a mean age of 47 (SD = 16.5) underwent gastroscopic biopsy and had an overall H. pylori prevalence of 24.6%. H. pylori infection was most commonly noted between 41 to 60 years of age. Gender did not seem to be significantly associated (p = 0.82) but gastrointestinal bleed was significantly associated with H. pylori infection (p = 0.006). The most common histopathological diagnosis was gastritis followed by gastrodudenitis; however, none of the diagnosis were found to be significantly associated with H. pylori infection. Conclusion: The overall prevalence of H. pylori infection was 24.6% and was most common between 40 to 60 years of age. Heart burn was the most common symptom and gastrointestinal bleed was the only significantly associated symptom with H. pylori infection.

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Nonsteroidal Anti-inflammatory Drug Use Is a Significant Cause of Peptic Ulcer Disease in a Tertiary Hospital in Singapore: A Prospective Study

Abstract: H. pylori negative peptic ulcer makes up a significant proportion of peptic ulcer in Singapore. Most of these ulcers were related to NSAID use. Serum thromboxane profile suggested surreptitious NSAID use in many of the non-H. pylori and apparently non-NSAID patients.

Cited by 26 publications

References 13 publications

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

Changes of Upper Gastrointestinal Symptoms and Endoscopic Findings in Japan Over 25 Years

Trends of Gastrointestinal Diseases at a Single Institution in Korea over the Past Two Decades

Prevalence of Helicobacter Pylori among Patients undergoing Gastrodudenoscopy in a Hospital in Western Nepal

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