Nonsquamous Pathologic Diseases of the Hypopharynx, Larynx, and Trachea

Brandwein-Gensler, Margaret; Mahadevia, Panna; Gnepp, Douglas R.

doi:10.1016/b978-1-4160-2589-4.00005-x

Cited by 13 publications

(12 citation statements)

References 526 publications

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“…Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus 6 and 11, and is characterized by wart‐like lesions spread throughout the respiratory tract with a preferred location in the larynx. The characteristic histopathologically appearance of RRP is the typical finger‐like projections of the squamous epithelium, each with a core of vascular connective tissue 6. The incidence of RRP according to the literature is 3.84 per 100,000 7.…”

Section: Introductionmentioning

confidence: 99%

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Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis

Halmos

Hemel

et al. 2012

The Laryngoscope

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Section: Introductionmentioning

confidence: 99%

“…The characteristic histopathologically appearance of RRP is the typical finger-like projections of the squamous epithelium, each with a core of vascular connective tissue. 6 The incidence of RRP according to the literature is 3.84 per 100,000. 7 Even though the incidence is very low, the burden for patients and their families can be…”

Section: Introductionmentioning

confidence: 99%

Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis

Halmos

Hemel

et al. 2012

The Laryngoscope

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“…2a), indicated a possible diagnosis of plasmacytoma [2]. However, the admixture of polymorphs and spindle cells, absence of monoclonal gammopathy and expression of both the kappa and lambda light chains confirmed with serum protein electrophoresis, conclusively ruled out plasmacytoma.…”

Section: Diagnosismentioning

confidence: 96%

Inflammatory Myofibroblastic Tumor: A Rapidly Growing Soft Tissue Mass in the Posterior Mandible

Sah

Byatnal

Rao

et al. 2013

Head and Neck Pathol

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The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Head and neck IMTs are rarely seen and comprise less than 5 % of tumors. Here we report a case of a 30 year old male who presented with a rapidly enlarging and extremely painful growth in the right posterior mandible, post extraction. Histopathological examination revealed a highly cellular connective tissue stroma comprised of spindle shaped cells arranged in fascicles, admixed with inflammatory cells, predominantly plasma cells. Apart from routine hematological investigations, serum protein electrophoresis was also performed. The final diagnosis was confirmed by a panel of immunomarkers consisting of MPO, CD34, CD20, CD3, CD23, CD138, SMA and ALK. To the best of our knowledge, this is the third case of oral IMT arising from an extraction socket.Keywords Inflammatory myofibroblastic tumour Á Inflammatory pseudotumor Á Gingiva Á Plasma cells Á Myofibroblasts Á Immunohistochemistry Case PresentationA 30-year old male presented with a painful, rapidly enlarging growth in the right posterior mandible of 1 month duration. The patient had undergone extraction of the right mandibular third molar about 4 months back, with persistence of postoperative pain in that region. The medical history was unremarkable. Clinical examination revealed a 7 9 5 cm reddish pink mass with an irregular surface in the right mandible. The mass extended from the extraction socket of the third molar to the canine and involved both buccal and lingual surfaces, almost covering the occlusal aspects of the teeth (Fig. 1a). The swelling was soft in consistency and elicited tenderness on palpation. Routine hematological investigations revealed mild leukocytosis (15,400 cells/mm 3 ) and an elevated erythrocyte sedimentation rate (107 mm). Fine needle aspiration cytology and histopathological examination following an incisional biopsy were inconclusive. The lesion continued to display rapid growth with involvement and progressive mobility of all the posterior teeth. Computed tomography of the mandible in the transverse plane revealed a hypodense area involving the premolar and molar region, associated with a breach in the continuity of the lingual cortical plate (Fig. 1b). 3-dimensional CT reconstruction confirmed this to be an osteolytic lesion giving the impression of an aggressive neoplasm, which necessitated repeating the incisional biopsy at two representative areas of the lesion.Parul Sah and Aditi Amit Byatnal have contributed equally to the manuscript.

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“…They are classified as nonmalignant due to absence of metastases or mitotic activity; however, they cause severe morbidity owing to infiltration of surrounding structures. These rare tumors occur in two to four persons per million and are exceedingly rare in the larynx, with only seven cases reported in the literature . Surgical excision with wide margins is the mainstay of treatment, with previous reports of laryngeal DTs describing total and near‐total laryngectomy to obtain negative margins …”

Section: Introductionmentioning

confidence: 99%

“…These rare tumors occur in two to four persons per million and are exceedingly rare in the larynx, with only seven cases reported in the literature. [1][2][3][4][5][6] Surgical excision with wide margins is the mainstay of treatment, with previous reports of laryngeal DTs describing total and near-total laryngectomy to obtain negative margins. 2,3 Computer-assisted design and three-dimensional (3D) modeling have been used in complex head and neck reconstruction of the maxilla, mandible, and orbit with reports of decreased operative time and improved accuracy.…”

Section: Introductionmentioning

confidence: 99%

Laryngeal reconstruction for recurrent desmoid tumor using three‐dimensional modeling: A unique approach for a rare tumor

et al. 2018

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Desmoid tumors are exceedingly rare within the larynx and cause significant morbidity due to their locally aggressive and infiltrative nature. Surgery is the mainstay of treatment with previous reports describing total and near‐total laryngectomy for cure. We present a case of recurrent glottic desmoid tumor managed with hemilaryngectomy and reconstructed with temporoparietal free tissue, rib, and buccal grafts. Three‐dimensional modeling was utilized to optimize aerodigestive function after laryngeal reconstruction. Laryngoscope, 129:1989–1992, 2019

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Nonsquamous Pathologic Diseases of the Hypopharynx, Larynx, and Trachea

Cited by 13 publications

References 526 publications

Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis

Narrow band imaging is a new technique in visualization of recurrent respiratory papillomatosis

Inflammatory Myofibroblastic Tumor: A Rapidly Growing Soft Tissue Mass in the Posterior Mandible

Laryngeal reconstruction for recurrent desmoid tumor using three‐dimensional modeling: A unique approach for a rare tumor

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