Nonspecific stimulation of the maternal immune system. II. Effects on gene expression in the fetus

Sharova, Lioudmila V.; Sura, Piotr; Smith, Bonnie J.; Gogal, Robert M.; Sharov, Alexei A.; Ward, Daniel L.; Holladay, Steven D.

doi:10.1002/1096-9926(200012)62:6<420::aid-tera9>3.0.co;2-8

Cited by 47 publications

(20 citation statements)

References 27 publications

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“…Certain cytokines of macrophage origin, interleukin-1b (IL-1b), tumour necrosis factor-a (TNF-a) and interferon are suspected of causing pregnancy loss and miscarriage (Raghupathy 1997). Transforming growth factor-b 2 (TGF-b 2 ) and TNF-a have been suggested as having a regulatory function in gene expression during organogenesis (Sharova et al 2000). Furthermore, a study to evaluate the possible involvement of a cytokine involved in pregnancy loss indicated that granulocytemacrophage colony-stimulating factor mediates the early stages of pregnancy loss via modulation of TNF-a and TGF-b 2 activity (Savion et al 2002).…”

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confidence: 99%

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

et al. 2006

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The possible involvement of cytokines such as tumour necrosis factor-a (TNF-a), interleukin-1b (IL-1b) and interferon-g (IFN-g) that are suspected of causing pregnancy loss and miscarriage has been investigated in dams of mice subjected to hyperthermia. Thermal stress was induced by exposing mice dams at 40721C for 4 h every day during the different phases of the gestation period whereas the normothermic animals were housed at 22721C. The effect of maternal thermal stress was measured in pregnant mice at different phases of the gestation period namely, blastogenesis-implantation phase (days 0-5 postconceptionem [p.c.]), organogenesis or embryogenesis phase (days 6-15 p.c.) and fetogenesis phase (days 16-20 p.c.). Uterine examination of dams subjected to hyperthermia on days 6-15 p.c. showed maximum reduction in live fetus number, gestational index and maximum pre-and postimplantation loss in comparison with dams housed in normothermic environment and dams exposed to thermal stress between days 0-5 and 16-20 p.c. Maximum resorption rate and number of non-viable fetuses were observed in dams exposed to hyperthermia during days 6-15 p.c. Elevated levels of TNF-a and IL-1b were observed in the amniotic fluid of dams subjected to hyperthermia during days 6-15 p.c. but IFN-g levels remained unaltered. Single intraperitoneal (i.p.) administration of recombinant mouse TNF-a at a dose of 1 and 0.5 ng/ mice in dams on day 6 in normothermic condition resulted in a reduced number of live fetuses. Administration of anti-TNF-a antibody i.p. at a dose of 10 mg/dam on day 6 p.c. and subjected to thermal stress between days 6-15 p.c. increased marginally the number of fetuses but failed to attain statistical significance in comparison with days 6-15 p.c. thermally stressed dams without antibody treatment. It is concluded that the induction of TNF-a, in the amniotic fluid is associated with thermal stress during pregnancy and may be linked to the reproductive performances of dams. This study will help in understanding the mechanism of thermal injury in pregnant subjects.

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confidence: 99%

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

et al. 2006

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“…Although the matter of how immune substrates and teratogenic metabolites interact at the cellular level is not yet clear, it is currently proposed that maternal immune stimulation may reduce chemically induced morphological lesions by an indirect effect via regulatory cytokine product of activated immune cells, in this respect Sharova et al (2000) theorized that such soluble mediators restore the teratogen-altered expression of critical fetal genes.…”

Section: Discussionmentioning

confidence: 99%

Association of Ipomoea carnea and BCG reduces birth defects caused by cyclophosphamide in rats

2007

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“…This phenomenon can be explained by lack of morphological signs of cartilage and other joint structure destruction, unvascularisation of epiphyses and immaturity of fetal immune system. High TNF-α expression is a consequence of the fact that this proinflammatory cytokine is one of the indispensable factor in organo-and fetogenesis (Sharova et al, 2000). Its expression argues a high developmental dynamic in the examined epiphyses.…”

Section: Control C3mentioning

confidence: 99%