Nonspecific provocation of target organs in allergic diseases: EAACI‐GA<sup>2</sup>LEN consensus report

Bonini, Sergio; Rasi, Guido; Brusasco, Vito; Carlsen, Kai‐Håkon; Crimi, Emanuele; Popov, Todor A.; Schultze‐Werninghaus, G.; Gramiccioni, Claudia; Bonini, Matteo; Passàli, Desiderio; Bachert, Claus; Cauwenberge, Paul B. Van; Bresciani, M; Calonge, Margarita; Montan, Per; Santos, Myrna Serapião dos; Belfort, Rubens; Lambìase, Alessandro

doi:10.1111/j.1398-9995.2007.01382.x

Cited by 27 publications

(30 citation statements)

References 88 publications

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“…Interrelationships between neurogenic and immune mechanisms of NAR should be studied using nasal biopsies, nasal challenge with various neuropeptides (123) and animal studies. Mechanisms: pharmacologic mechanisms (ASA) Aspirin (ASA) and nonsteroidal drugs are considered to be common triggers of NAR and asthma.…”

Section: Mechanisms: Neurogenic Mechanismsmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

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166

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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Section: Mechanisms: Neurogenic Mechanismsmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

Self Cite

166

148

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show abstract

“…Nasal hyperreactivity to specific or nonspecific provocative agents is a principal feature of AR [6]. Nasal provocation tests with different provocative agents may reflect different aspects of the nasal inflammatory process [7], and has been used to assess the onset, effectiveness and tolerability of therapy [8].…”

Section: Introductionmentioning

confidence: 99%

Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Zhu

Xie

Guan

et al. 2016

Asia Pacific Allergy

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BackgroundThe symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear.ObjectiveTo evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR.MethodsPatients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed.ResultsA total of 25 eligible AR patients enrolled and finished both LTD4 and histamine nasal challenge and completed the questionnaire of RQoLQ. Histamine nasal challenge induced sneezing, increased nasal resistant were correlated with most of the dimensions (general, practical, nasal, eye problems, and quality of sleep, p < 0.05), while LTD4 nasal challenge induced sneeze, increased nasal resistant only correlated with nasal and ocular problems. On the contrary, the severity of the sneeze assessed by TSS4, was not correlated with QoL, while the severity of rhinorrhea, congestion, and nasal pruritus were correlated with nasal and practical problems, and nasal congestion was also correlated with ocular problems (r = 0.60, p = 0.01).ConclusionLTD4 and histamine nasal challenge induced nasal responses were correlated with different clinical symptoms severity and QoL, which can be used as a good diagnosis and evaluation methods for the management of AR.

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“…7,8 Different inflammatory mediators may play different roles in the pathogenesis of AR. 12 In addition, there exist various phenotypes and inflammatory subtypes of AR. Nasal hyperreactivity to specific or non-specific provocative agents is a principal feature of AR.…”

Section: Introductionmentioning

confidence: 99%

Effects of leukotriene D₄ and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients

Zhu

Xie

Guan

et al. 2016

Clinical Respiratory J

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LTD and histamine nasal challenge caused different patterns and severities of nasal symptoms, which correlated with symptoms (TSS) that affect patient's daily life. LTD4 was far more potent than histamine at increasing the NAR, while histamine nasal challenge induced more sneezing and nasal discharge. These results may guide the prescription of anti-histamine or anti-leukotriene agents for treating different AR phenotypes.

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Nonspecific provocation of target organs in allergic diseases: EAACI‐GA²LEN consensus report

Cited by 27 publications

References 88 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Effects of leukotriene D₄ and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients

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Nonspecific provocation of target organs in allergic diseases: EAACI‐GA2LEN consensus report

Cited by 27 publications

References 88 publications

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis

Effects of leukotriene D4 and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients

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Nonspecific provocation of target organs in allergic diseases: EAACI‐GA²LEN consensus report

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Effects of leukotriene D₄ and histamine nasal challenge on airway responsiveness and inflammation in persistent allergic rhinitis patients