Abstract:One-sentence summary: The covalent linker between BK intracellular and transmembrane domains is likely a part of the sensing apparatus that regulates the channel activation. # Equal contributions * Corresponding Authors: Jianmin Cui: Phone: (314) 935-8896;
AbstractLarge-conductance potassium (BK) channels are transmembrane (TM) proteins that can be synergistically and independently activated by membrane voltage and intracellular Ca 2+ . The only covalent connection between the cytosolic Ca 2+ sensing domain … Show more
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