Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients.

Park, Jai Soung; Lee, Kyung Soo; Kim, Jeung Sook; Park, Choon-Sik; Suh, Yeon‐Lim; Choi, Deuk Lin; Kim, Ki‐Jung

doi:10.1148/radiology.195.3.7753988

Cited by 157 publications

(77 citation statements)

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“…Both irregular linear opacities and air-space consolidations have been described as characteristic features (1,4,8). The CT features of NSIP have also been reported (4). In the present study, the predominant CTfeature was interstitial and patchy parenchymal opacification in both lungs predominantly in the middle and lower lung zones.…”

Section: Case Reportsupporting

confidence: 78%

“…According to those reports, it is suggested that 10-20% of patients with NSIP died because of respiratory failure. Since NSIP has been described only recently, knowledge of its radiographic manifestations is limited ( 1,4,8). Both irregular linear opacities and air-space consolidations have been described as characteristic features (1,4,8).…”

Section: Case Reportmentioning

confidence: 99%

“…Since NSIP has been described only recently, knowledge of its radiographic manifestations is limited ( 1,4,8). Both irregular linear opacities and air-space consolidations have been described as characteristic features (1,4,8). The CT features of NSIP have also been reported (4).…”

Section: Case Reportmentioning

confidence: 99%

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Clinical Features of Three Fatal Cases of Non-specific Interstitial Pneumonia.

et al. 2000

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Wedescribe the clinical courses of the 3 fatal patients (2 females and 1 male) with idiopathic non-specific interstitial pneumonia (NSIP) among 24 patients with NSIP. Lung biopsies were diagnosed to be NSIP group II in all patients. The clinical courses from onset to death of these 3 patients were 41 months, 46 months, and 91 months. A follow-up chest CT demonstrated no apparent honey-combformation. Wefound that i) about 20%of patients with NSIP died of respiratory failure, ii) in the chest CT findings, apparent honey-combformation was rare even just before death, iii) prediction of the prognosis based on the histological findings was difficult. This is the first report to describe the clinical features of deceased patients with idiopathic NSIP; the incidence of fatal cases was considered to range from 10 to 20%.

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Section: Case Reportsupporting

confidence: 78%

Section: Case Reportmentioning

confidence: 99%

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Clinical Features of Three Fatal Cases of Non-specific Interstitial Pneumonia.

et al. 2000

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“…(HandE,xlOO) limited [13]. Recently, radiographic and high resolution CT findings of the disease were de scribed [14]. However, this report included only sevencasesof the disease.Furthermore, we know of no reports on correlation of high resolution CT' and pathologic findings.…”

mentioning

confidence: 99%

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Kim¹,

Lee²,

Chung³

et al. 1998

American Journal of Roentgenology

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163

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OBJECTIVE. The purposeof our studywas to describehigh-resolutionCT findingsof nonspecific interstitial pneumonia with fibrosis and to compare findings seen on CT with pathologic findings. MATERIALS AND METHODS. High-resolutionCT findingsof biopsy-provennonspecific interstitial pneumonia with fibrosis from 23 consecutive patients (one man and 22 women) were analyzed retrospectively by two chest radiologists. CT findings were compared with pathologic findings.RESULTS. The predominant high-resolution CT finding,seenin all patients,wasbilateral patchy areasof ground-glass opacity with (35%) or without (65%) areasof consolidation. Ir regular linear opacities (87%), thickening of bronchovascular bundles (65%), and bronchial dilatation (52%) were also frequently seen. Honeycombing was not seen in any patient. All parenchymal abnormalities showed subpleural predominance. Areas of ground-glass opacity with or without irregular linear opacity or bronchial dilatation on CT correspondedpathologi cally to areasof interstitial thickening causedby varying degreesof interstitial inflammation and fibrosisshowingtemporaluniformity.Areas of consolidation, seenat five biopsysites, represented the areas of bronchiolitis obliterans organizing pneumonia, foamy cell collections in alveolar spaces,or microscopic honeycombing with mucin stasis. CONCLUSION.On high-resolutionCT, nonspecificinterstitialpneumoniawith fibrosis is most commonly revealed as patchy subpleural areasof ground-glass opacity mixed with ir regular linear opacity or bronchial dilatation. These areas represent interstitial thickening caused by varying degrees of interstitial inflammation, fibrosis, or both.

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“…Many reports have described that corticosteroids are effective for NSIP (1)(2)(3)(4)(5)(6)(7)(8)(9). In addition, although other immunosuppressants (such as cyclophosphamide or azathioprine), have been used in patients with NSIPin whomcorticosteroids were ineffective, the role of these immunosuppressants in patients with NSIP has not been clarified (1,(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Nonspecific Interstitial Pneumonia/Fibrosis Completely Recovered by Adding Cyclophosphamide to Corticosteroids.

et al. 2002

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Nonspecific interstitial pneumonia/fibrosis (NSIP) was first described by Katzenstein and Fiorelli in 1994 (Am J Surg Pathol 18: 136-147). Many reports have described that corticosteroids are effective for NSIP.Wedescribe a case of group II idiopathic NSIP in whomcyclophosphamide was administered since the initial response to corticosteroids had been insufficient. Lung biopsy was performed by video-assisted thoracoscopic surgery and NSIP was diagnosed pathologically, clinically and radiologically. Although the initial response to corticosteroids was insufficient, interstitial infiltrates on chest computed tomography improved dramatically after adding intravenous cyclophosphamide followed by oral cyclophosphamide. This case demonstrates that the addition of cyclophosphamide to corticosteroids might be a useful treatment for patients with NSIP. (Internal Medicine 41 : 867-870, 2002)

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Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients.

Abstract: Bilateral patchy areas of opacity depicted radiographically and good clinical response to treatment may differentiate NIP from other interstitial pneumonias.

Cited by 157 publications

References 0 publications

Clinical Features of Three Fatal Cases of Non-specific Interstitial Pneumonia.

Clinical Features of Three Fatal Cases of Non-specific Interstitial Pneumonia.

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Nonspecific Interstitial Pneumonia/Fibrosis Completely Recovered by Adding Cyclophosphamide to Corticosteroids.

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