Nonspecific Granulomatous Prostatitis

Pavlica, Pietro; Barozzi, Libero; Bartolone, Alessia; Gaudiano, Caterina; Menchi, M; Veneziano, S

doi:10.1055/s-2005-858072

Cited by 12 publications

(2 citation statements)

References 15 publications

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“…It is now believed that nonspecific granulomatous prostatitis is autoimmune based with HLA-DR15-linked T cell response against proteins in prostatic secretions, especially PSA 5, 24. DRE findings and PSA levels often lead to erroneous interpretation of carcinoma prostate 25 . Patients may present with symptoms of urinary obstruction or signs and symptoms of infection.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous prostatitis: clinical and histomorphologic survey of the disease in a tertiary care hospital

Shukla

Gulwani

Kaur

2017

Prostate International

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BackgroundGranulomatous prostatitis is an uncommon entity that is diagnosed incidentally on histopathology and is broadly classified as nonspecific, specific, postsurgical (post-transurethral resection), or secondary to other rare systemic granulomatous diseases. Only very few studies are available in the literature that describe the clinical and histomorphological spectrum of the disease.MethodsA retrospective analysis of histopathological records of 1,181 prostatic specimens received in the pathology department was done over a period of 13 years (January 2003 to January 2016). All histologically proven cases of granulomatous prostatitis were retrieved, and relevant clinical data were collected from patients’ records. Epstein and Hutchins classification was used to categorize these cases.ResultsTwenty-two cases of granulomatous prostatitis were identified, accounting for an incidence of 1.86%. Among these, nonspecific granulomatous prostatitis (n = 10) was the most common followed by tubercular prostatitis (n = 5), posttransurethral resection of the prostate (n = 3), allergic (n = 2), and xanthogranulomatous prostatitis (n = 2). The age range of these patients was between 41 and 75 years, with the majority of patients in their 7th decade. Serum prostate-specific antigen levels ranged between 0.88 ng/mL and 19.22 ng/mL. Hard and fixed nodules were observed on digital rectal examination in 14 cases. Transrectal ultrasound revealed hypoechoic shadows in five cases.ConclusionDespite present-day advances in imaging modalities and serological investigations, it is virtually impossible to identify granulomatous prostatitis clinically. Histopathology remains the gold standard in diagnosing the disease. However, assigning an etiologic cause to the wide spectrum of granulomas in granulomatous prostatitis requires a pathologist’s expertise and proper clinical correlation for appropriate patient management.

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Section: Discussionmentioning

confidence: 99%

Granulomatous prostatitis: clinical and histomorphologic survey of the disease in a tertiary care hospital

Shukla

Gulwani

Kaur

2017

Prostate International

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“…Nevertheless, the incidence of GP is growing due to the increase of endourological surgical interventions and the adoption of intravesical instillation of Bacillus Calmette-Guerin (BCG) in patients with non-muscle invasive bladder cancer (NMIBC) ( 6 , 7 ).…”

Section: Introductionmentioning

confidence: 99%

Multiparametric magnetic resonance imaging for the differential diagnosis between granulomatous prostatitis and prostate cancer: a literature review to an intriguing diagnostic challenge

Gaudiano,

Renzetti,

De Fino

et al. 2023

Front. Oncol.

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Multiparametric magnetic resonance imaging (mpMRI) is currently the most effective diagnostic tool for detecting prostate cancer (PCa) and evaluating adenocarcinoma-mimicking lesions of the prostate gland, among which granulomatous prostatitis (GP) represents the most interesting diagnostic challenge. GP consists of a heterogeneous group of chronic inflammatory lesions that can be differentiated into four types: idiopathic, infective, iatrogenic, and associated with systemic granulomatous disease. The incidence of GP is growing due to the increase in endourological surgical interventions and the adoption of intravesical instillation of Bacillus Calmette-Guerin in patients with non-muscle invasive bladder cancer; therefore, the difficulty lies in identifying specific features of GP on mpMRI to avoid the use of transrectal prostate biopsy as much as possible.

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