Nonspecific and beta-adrenergic blocking effects of Alderlin in angina pectoris

Propranolol and Angina Pectoris

“…The other five patients showed no subjective improvement nor did the results of the work test. The percentage of cases, where no beneficial effect was found, was similar to most earlier reports (1,4,8,9,12,13,15). It has not been explained why some patients do not benefit from this therapy.…”

“…A new principle for the treatment of patients with angina pectoris has been introduced by means of adrenergic Bblocking agents. Their therapeutic effect has been well established in many clinical double-blind studies (1, 4, 9,12,15). The favourable action of these drugs on patients with angina pectoris is said to be due to a reduction in the work of the left ventricle and the oxygen demand in the myocardium during exercise (2, 8, 13).…”

Hypotensive action of propranolol

“…Patients with asthma,22 chronic bronchitis, or a tendency to develop heart failure 4 should not receive propranolol as a hypotensive agent. Propranolol had no significant hypotensive effect in normotensive subjects, a finding previously reported for both oral5, 34,41 and intravenous 9 , 11, 15, 43 pronethalol. Prichard"o claims that the hypotensive action of oral propranolol and pronethalol is seen only after prolonged administration.…”