Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia

Lencz, Todd; Smith, Christopher W.; Auther, Andrea M.; Correll, Christoph U.; Cornblatt, Barbara A.

doi:10.1016/s0920-9964(03)00214-7

Cited by 206 publications

(175 citation statements)

References 42 publications

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“…Once again, this finding is entirely consistent with other VCFS longitudinal data 47 as well as the non-VCFS schizophrenia research [84][85][86][87][88][89] .…”

Section: Discussion Psychiatric and Cognitive Functioningsupporting

confidence: 90%

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Antshel

Shprintzen

Fremont

et al. 2010

Journal of the American Academy of Child & Adolescent Psych

133

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Objective-To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS).Method-70 youth with VCFS, 27 siblings of youth with VCFS and 25 community controls were followed from childhood (Mean age = 11.8 years) into mid-adolescence (mean age 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points.Results-Major depressive disorder, oppositional defiant disorder and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positives, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test.Conclusions-Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention. KeywordsVelocardiofacial syndrome (VCFS); 22q11 deletion syndrome; cognition; psychosis; longitudinal Velo-cardio-facial syndrome (VCFS) is caused by an interstitial deletion from chromosome 22 at the 22q11 band. The most common microdeletion syndrome yet identified in humans, VCFS has a population prevalence of approximately 1:2000 to 1:6000 live births 1, 2 . In most cases, VCFS is caused by a hemizygous deletion of 3 million base pairs of DNA encompassing 40 genes but approximately 8% have smaller nested deletions of 1.5 million base pairs spanning 34 genes 3 . Structural anomalies affect nearly every part and system of the body and may Correspondence to: Kevin Antshel, Ph.D. SUNY -Upstate Medical University Department of Psychiatry and Behavioral Sciences, 750 East Adams Street, Syracuse, NY 13210; AntshelK@upstate.edu. Disclosure: Dr. Faraone, in the past year, has received consulting fees and has been on Advisory Boards for Eli Lilly, Ortho-McNeil, and Shire Development, and has received research support from Eli Lilly, Pfizer, Shire and the National Institutes of Health. In previous years, Dr. Faraone has received consulting fees or has been on advisory boards, or has been a speaker for the following sources: Shire, McNeil, Janssen, Novartis, Pfizer, and Eli Lilly. In previous years he has received research support from Eli Lilly, Shire, Pfizer and the National Institutes of Health. Drs. Antshel, Shprintzen, Fremont, and Kates, and Ms. Higgins report no biomedical financial interests or potential conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the prod...

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“…Once again, this finding is entirely consistent with other VCFS longitudinal data 47 as well as the non-VCFS schizophrenia research [84][85][86][87][88][89] .…”

Section: Discussion Psychiatric and Cognitive Functioningsupporting

confidence: 90%

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Antshel

Shprintzen

Fremont

et al. 2010

Journal of the American Academy of Child & Adolescent Psych

133

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“…However, the relatively high prevalence of these symptoms would suggest a lack of specificity in terms of risk for psychosis. This is, in fact, in line with recent research, which suggests that psychotic symptoms reported both in the clinic and in the community index risk for a much wider range of psychopathology than psychotic disorders (Addington et al, 2011, Kelleher et al, 2011b, Lencz et al, 2004. Varghese et al, (2011 Two recent studies suggest that age is an important factor in the relationship between psychotic symptoms and psychopathology.…”

Section: Discussionsupporting

confidence: 88%

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

et al. 2012

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Cannon M. Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies. Psychological Medicine. 2012; 9:1-7. AuthorsIan Kelleher, Dearbhla Connor, Mary C. Clarke, Nina Devlin, Michelle Harley, and Mary Cannon This article is available at e-publications@RCSI: http://epubs.rcsi.ie/psychart/1 -Use LicenceAttribution-Non-Commercial-ShareAlike 1.0 You are free:• to copy, distribute, display, and perform the work.• to make derivative works. Under the following conditions:• Attribution -You must give the original author credit.• Non-Commercial -You may not use this work for commercial purposes.• Share Alike -If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.

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“…The at-risk population by default is young, including children and adolescents, where there is a distinct lack of data regarding the use of psychotropics, including atypical antipsychotics in this population. Although some studies have shown efficacy of using atypicals [12,49] in putatively prodromal patients, side effects have been observed and the long-term effects are not known. Not all interventions must include psychotropics.…”

Section: Discussionmentioning

confidence: 99%

“…Hawkins et al [11] did an exploratory factor analysis of individual symptom ratings from the SIPS in 94 putatively prodromal patients that showed loading on positive and negative symptom factors, whereas the symptom of conceptual disorganization did not load with either of these factors, consistent with the three-factor symptom model of schizophrenia. Lencz et al [12] reported that in 82 high-risk patients, social isolation and/or withdrawal were the most commonly reported symptom at initial presentation, and found that disorganized (eg, odd behavior and/or appearance) and negative symptoms also were prevalent, highlighting the likely importance of these symptoms in addition to functional deterioration as risk factors for schizophrenia.…”

Section: Schizophrenia Prodromementioning

confidence: 99%

Progress in the prospective study of the schizophrenia prodrome

Fu¹,

Cadenhead

2005

Current Psychosis & Therapeutics Reports

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Further understanding of the schizophrenia spectrum has helped to define the prodrome of the illness, leading to hopes of earlier identification and intervention in susceptible, at-risk individuals. Given the heterogeneity and comorbidity observed in the clinically and demographically identified prodromal sample, it is essential that neurobiological markers that are more closely linked to brain function, and perhaps the ability to predict evolution of psychosis, be identified. Ultimately, it may be possible to identify an algorithm of risk factors that will combine clinical and demographic risk factors with vulnerability markers associated with later development of schizophrenia to better target at-risk individuals or preventative treatment.

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Nonspecific and attenuated negative symptoms in patients at clinical high-risk for schizophrenia

Cited by 206 publications

References 42 publications

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome: A 3-Year Follow-Up Study

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

Progress in the prospective study of the schizophrenia prodrome

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